Body Composition in Iraqi Women With Systemic Lupus Erythematosus

Gorial, Faiq I.; Mahmood, Zainab A.; Obaidi, Sundus Al

doi:10.5539/gjhs.v11n1p63

Cited by 7 publications

(9 citation statements)

References 9 publications

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“…Positive smokers made up 2.9 percent of SLE patients in the current investigation, which was similar to previous results [24], and no significant variations in BMI values were seen when compared to healthy people [25]. All of the subjects in this study had active disease, and the SLEDI value was 16.4, which was lower than the value reported by other researchers [24]. The majority of patients were treated with steroids and HCQ, with varying values for the other medicines, according to the current study, which was consistent with a previous report.…”

Section: Resultssupporting

confidence: 93%

“…The optimum cut off point of RPR was 0.0455, and the analysis of data showed that this cut off point had 79% sensitivity, 51% specificity 51%, 65% accuracy, 62% PPV 62%, and 70.6% NP (Table 6). Positive smokers made up 2.9 percent of SLE patients in the current investigation, which was similar to previous results [24], and no significant variations in BMI values were seen when compared to healthy people [25]. All of the subjects in this study had active disease, and the SLEDI value was 16.4, which was lower than the value reported by other researchers [24].…”

Section: Resultssupporting

confidence: 89%

“…The majority of patients were treated with steroids and HCQ, with varying values for the other medicines, according to the current study, which was consistent with a previous report. Furthermore, the SLEDI value given was found to be lower than that of Gorial et al, indicating a reduced rate of active disease status [24]. In terms of proteinuria, the recent study found that 35.9% of SLE patients are proteinuric.…”

Section: Resultsmentioning

confidence: 74%

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Association between Red Cell Distribution Width to Platelet Ratio and Disease Activity among Iraqi Patients with Systemic Lupus Erythematosus

Gorial

Ali

Naema

et al. 2021

Al-Rafidain J Med Sci

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Background: The link between red blood cell distribution width-to-platelet ratio (RPR) and disease activity in systemic lupus erythematosus (SLE) is not well understood. Aim: To investigate the association between RPR levels and disease activity in SLE. Methods: This was a case-control study conducted at Baghdad Teaching Hospital, Medical City from July 2020 to March 2021. Seventy SLE patients were compared with 70 healthy controls. The diagnosis was made using the American College of Rheumatology SLE criteria. Results: SLE patients had a mean age of 35.2±12.03 years, while controls had a mean age of 36.3±9.9 years (P=0.5). Females represent 97.1% of SLE patients and 88.6% of controls. The average disease duration was 4.98±0.05 years. The disease activity index (SLEDI) was 16.4±4.8. SLE patients had a lower platelet count than controls, and the median (IQR) of RDW was larger than that of controls. SLE patients had a greater median (IQR) of RPR than controls (0.058; 0.04-0.07 vs. 0.045; 0.039-0.053). The RPR and SLEDAI showed strong positive association. The optimal cutoff point for distinguishing SLE patients from controls was 0.0455, with 79% sensitivity and 51% specificity. The RPR was not significantly affected by sociodemographic or clinical factors. Conclusion: The RPR was positively correlated with disease activity in SLE patients, and may be a valid measure to differentiate between SLE patients and healthy controls. Sociodemographic and other clinical characteristics do not significantly affect RPR.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 74%

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Association between Red Cell Distribution Width to Platelet Ratio and Disease Activity among Iraqi Patients with Systemic Lupus Erythematosus

Gorial

Ali

Naema

et al. 2021

Al-Rafidain J Med Sci

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“…20 Another Iraqi study assessed body composition in Iraqi women with systemic lupus erythematosus revealed that there was no significant difference between body composition of lupus patients and controls. 21 Also, it has been reported that patients with spondyloarthritis and systemic sclerosis tend to have higher risk of sarcopenia than matched controls. 22 In systemic sclerosis, sarcopenic patients were found to have longer disease duration, worse lungs, and skin involvement.…”

Section: Discussionmentioning

confidence: 99%

Presarcopenia in Patients with Vitiligo: A Case Control Study

Gorial

Jehad

Taha

et al. 2021

MJR

Self Cite

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Background: Sarcopenia is a muscle disease with significant morbidity and mortality. Vitiligo is a common autoimmune inflammatory disease which results from absence, deficiency, or dysfunction of melanocytes. Links between sarcopenia and autoimmune inflammatory processes were reported. However, no previous reports on association between sarcopenia and vitiligo were identified. Objective: To assess presarcopenia in patients with vitiligo and to evaluate the effect of sociodemographic and clinical characteristics of vitiligo patients of sarcopenia if present. Subject and methods: This case control study included 63 patients with Vitiligo and 63 apparently healthy control group matched in age and gender. Sarcopenia was diagnosed by measuring the Appendicular Lean Mass Index. Cut off point required for sarcopenia is <6 for women and <7 for men. Sociodemographic and clinical characteristics were recorded. Sarcopenia was diagnosed according to the 2018 revised European consensus on definition and diagnosis of sarcopenia. Results: Mean age of vitiligo patients was 38.7 ± 14.0 years (range: 20–69 years) and for controls 39.9 ± 11.6 years (range: 20–70 years) (p=0.604). Female were 34 (54.0%) and 29 (46.0%) males, while in the controls 30 (47.6%) were females and 33 (52.4%) males (p=0.604). Presarcopenia was significantly higher in Vitiligo compared to controls. Vitiligo increases the risk of having presarcopenia by about five-fold (OR [95%CI]=4.706[1.26–17.61], p=0.013).Only BMI was significantly negatively correlated with presarcopenia. BMI decreases the risk of having presarcopenia by odds ratio of 0.837 (0.032). other baseline characteristics had no significant impact of presarcopenia in vitiligo (P model<0.01, R 2 =0.46 Accuracy= 0.57 AUC=0.92). Conclusions: Vitiligo was significantly positively correlated with presarcopenia and increased the risk of presarcopenia by about five-fold.

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“…By leading to reduced muscle power, resistance, and physical activity, the loss of muscle mass contributes to the restriction in functional independence and daily living activities [11]. Up to our knowledge, no previously reported study has examined the prevalence of sarcopenia in the Iraqi population, however, some studies estimated the prevalence of sarcopenia in certain diseases like systemic lupus erythematosus [12].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of sarcopenia in adult patients with ankylosing spondylitis

Younis

Al-Bedri²

2021

RBGJ

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Ankylosing Spondylitis is a chronic, progressive inflammatory rheumatic disease that involves primarily the sacroiliac joints and the axial skeleton. Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability and poor quality of life. The study aimed to assess the prevalence of sarcopenia in patients with ankylosing spondylitis. A case-control study was conducted at Rheumatology Unit from January 2019 to July 2019. The study population consisted of 50 Iraqi patients diagnosed with AS and 50 healthy control. Demographic data, physical activity using General Practice Physical Activity Questionnaire (GPPAQ), disease activity scores using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were recorded. Sarcopenia assessment was done by using a dual-energy x-ray absorptiometry scan for body composition analysis and measuring skeletal mass index (SMI). The maximal voluntary grip strength of the hand was measured with an electronic dynamometer. Physical function was assessed by a 4-meter usual gait speed test. The prevalence of presarcopenia was 6% in both studied groups, while sarcopenia was 10% in AS patients. The mean value of BMI is significantly lower in patients with sarcopenia than in those without (p=0.001). The vast majority of the sarcopenic group (80%) were physically inactive which was statistically significant compared with the non-sarcopenic group (p=0.033). No significant association of treatment with anti-TNF or its duration was found between sarcopenia and non-sarcopenia groups (p=0.377; p=0.187). Both LM and handgrip showed fair validity to differentiate between AS patients and controls. Patients with AS are at higher risk of developing early sarcopenia than in healthy controls. Lower BMI and longer disease duration increase the risk of sarcopenia, while differences in gender, smoking and the use of anti-TNF do not influence the risk. Physical activity may improve muscle strength and perhaps decrease the risk.

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Body Composition in Iraqi Women With Systemic Lupus Erythematosus

Cited by 7 publications

References 9 publications

Association between Red Cell Distribution Width to Platelet Ratio and Disease Activity among Iraqi Patients with Systemic Lupus Erythematosus

Association between Red Cell Distribution Width to Platelet Ratio and Disease Activity among Iraqi Patients with Systemic Lupus Erythematosus

Presarcopenia in Patients with Vitiligo: A Case Control Study

Prevalence of sarcopenia in adult patients with ankylosing spondylitis

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