Body Composition in Acromegaly: The Effect of Treatment

Bengtsson, Bengt‐Åke; Brummer, Robert Jan; Edén, Staffan; Bosæus, Ingvar; Lindstedt, Göran

doi:10.1111/j.1365-2265.1989.tb01272.x

Cited by 55 publications

(39 citation statements)

References 25 publications

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“…For subjects at rest, many studies have demonstrated the sodium-and water-retaining effects of GH (1±3). Body-¯uid volume decreases in GHde®cient patients (3), but increases in acromegalic patients, who secrete excess GH (1,4). In both groups of patients, body¯uid is normalized after, respectively, GH treatment and surgical treatment of the hypophysis.…”

Section: Introductionmentioning

confidence: 90%

Effect of hydration on exercise-induced growth hormone response

Peyreigne¹,

Bouix²,

Fédou³

et al. 2001

European Journal of Endocrinology

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Design: Growth hormone (GH) has demonstrated water-retaining effects in subjects at rest, whereas other research has indicated that GH may stimulate sweating. Thus, the aim of this study was to investigate the effect of¯uid intake on the exercise-induced GH response. Methods: Seven healthy male volunteers (age: 27X4^1X3 years, weight: 74X5^1X1 kgY height: 179X32X3 cm performed a 40-min submaximal rectangular cycling exercise in two different sessions. The ®rst session (Session 1) was performed without water intake, and the second (Session 2) involved the ingestion of spring water (four intakes) corresponding to the volume of water lost during the ®rst session. Results: In session 1, the water loss was 568^32 mlX In Session 2, the volume of water loss was not signi®cantly different from the volume of¯uid intake 524^16 versus 568^32 ml respectively). The decrease in plasma volume was signi®cantly reduced in Session 2 26X69^1X59% versus 211X31 X89%; P , 0X05X In Session 1, the GH concentration was signi®cantly lower than that during Session 2 after 25 min 3X04^1X05 versus 5X26^1X81; P , 0X05 and after 40 min 13X7^3X55 versus 17X60^4X14 ngaml; P , 0X05 of exercise. The total GH response was signi®cantly lower in Session 1 than in Session 2 136X6^39X2 versus 202X4^58X9 ngamlXmin; P , 0X05X Conclusions: We conclude that the exercise-induced GH response decreases when exercise is performed without¯uid intake.

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Section: Introductionmentioning

confidence: 90%

Effect of hydration on exercise-induced growth hormone response

Peyreigne¹,

Bouix²,

Fédou³

et al. 2001

European Journal of Endocrinology

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“…Indirect calorimetry. Oxygen consumption (vO 2 ) and carbon dioxide production (vCO 2 (45,46). Sections were made at the same level in all mice (i.e., 5 mm proximally of the crista iliaca).…”

Section: Methodsmentioning

confidence: 99%

“…t is well known that growth hormone (GH) decreases body fat mass in both man and experimental animals (1)(2)(3)(4)(5)(6). Using zinc to control the metallothioneine promoter driving the ovine-GH gene, a GH dose-dependent linear decrease in both epididymal and subcutaneous fat pad weights was found (7).…”

mentioning

confidence: 99%

Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia

et al. 2005

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It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that on appetite. The transgenic mice were not GH-deficient but were obese and showed increased food intake as well as increased hypothalamic expression of agouti-related protein and neuropeptide Y. GH also had an acute effect on food intake following intracerebroventricular injection of C57BL/6 mice. The transgenic mice were severely hyperinsulinemic and showed a marked hyperplasia of the islets of Langerhans. In addition, the transgenic mice displayed alterations in serum lipid and lipoprotein levels and hepatic gene expression. In conclusion, GH overexpression in the CNS results in hyperphagia-induced obesity indicating a dual effect of GH with a central stimulation of appetite and a peripheral lipolytic effect. Diabetes 54:51-62, 2005

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“…Dual-energy X-ray absorptiometry (DEXA), introduced more recently in the assessment of BC, has the advantage of providing a comprehensive, non-invasive estimate of each tissue compartment. BC changes in acromegaly, namely body weight, lean body mass (LBM), and bone mineral content (BMC) increase, while fat mass (FM) is reduced (3,(6)(7)(8)(9), but differences between genders have not been previously described. Increased body fat, and especially visceral fat, is associated with an increase in cardiovascular risk in normal population (10,11) and different diseases (11)(12)(13); whether a decrease in body fat is related to changes in cardiovascular risk in acromegaly is not known.…”

Section: Introductionmentioning

confidence: 99%

“…Body composition (BC) in acromegaly has been previously evaluated with bioelectrical impedance analysis, total body potassium, total body water, and anthropometry (1)(2)(3)(4)(5). Dual-energy X-ray absorptiometry (DEXA), introduced more recently in the assessment of BC, has the advantage of providing a comprehensive, non-invasive estimate of each tissue compartment.…”

Section: Introductionmentioning

confidence: 99%

Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females

Sucunza

Barahona²,

Resmini³

et al. 2008

European Journal of Endocrinology

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Background: Acromegaly changes body composition (BC), but long-term gender differences have not been reported. Objective: To evaluate BC in active and controlled acromegalic patients. Design and methods: Clinical and biochemical variables and BC (by dual-energy X-ray absorptiometry) were evaluated in 60 acromegalic patients (19 active, 41 controlled) and 105 controls, matched for age and gender. Results: Acromegalic males (nZ24) had more total mass (89G13 vs 76.5G15.3 kg, P!0.001), lean body mass (LBM; 64.6G8.7 vs 56.4G5.8 kg, P!0.001), and bone mineral content (BMC; 2.9G0.5 vs 2.6G0.3 kg, P!0.05) than controls (nZ33). Controlled male patients (nZ14) had more total mass (89G14.7 vs 76.5G15.3 kg, P!0.05) and a trend to have more LBM (61.8G9.4 vs 56.4G5.8 kg, PZ0.065) than controls. Only in active disease was a decrease in fat mass (FM) observed, compared with controlled patients and controls (males: 19.5G5.3 vs 27G6.2 and 25.9G4%, P!0.001; females: 30.3G 6.7 vs 37.1G5.8 and 36.5G6.6%, P!0.01). In females, no further differences were observed. No differences in BMC were found between eugonadal and hypogonadal acromegalic patients, but in hypogonadal females, acromegaly appeared to prevent the BMC loss seen in hypogonadal postmenopausal controls. GH and IGF1 levels were negatively correlated with FM (males, P!0.05; females, P!0.001), but in the regression analysis GH was a predictor of FM only in women. Conclusions: Control of acromegaly reverts decreased FM in both genders; only in males more total mass and a trend for more LBM persist. The anabolic effect of GH on bone reverted in cured males, but persisted in females and appeared to override the bone loss of menopause.

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Body Composition in Acromegaly: The Effect of Treatment

Cited by 55 publications

References 25 publications

Effect of hydration on exercise-induced growth hormone response

Effect of hydration on exercise-induced growth hormone response

Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia

Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females

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