Body composition and serum levels of adiponectin, vascular endothelial growth factor, and interleukin-6 in patients with rheumatoid arthritis

Abstract

AimTo investigate differences in body composition and body mass index (BMI) in patients with rheumatoid arthritis (RA) and their correlations with serum production of adiponectin, interleukin-6 (IL-6), and vascular endothelial growth factor (VEGF).MethodsThe study included 83 patients (age 53 ± 5 years) with RA treated with methotrexate. We determined their BMI, fat mass, and fat-free mass using bioimpedance analysis, and serum concentrations of adiponectin, VEGF, and IL-6 using immunoassay analysis.ResultsNormal BMI was found in 39 (47%), overweight and obesity in 26 (31%), and underweight in 18 (22%) patients. Concentration of adiponectin was lower in overweight/obese patients than in patients with normal BMI (2.1 [0.8-3.9] μg/mL vs 8.9 (7.2-11.3) μg/mL). In underweight patients, it was moderately increased (12.7 [9.3-14.8] μg/mL) and the correlation between the concentrations of adiponectin and IL-6 was positive (r = 0.4; P = 0.01). Concentrations of VEGF and IL-6 were increased in all groups with RA. The overweight/obese group showed a negative correlation between the concentrations of adiponectin and VEGF (r = - 0.34; P = 0.04), a positive correlation between VEGF concentration and fat mass (r = 0.39; P = 0.02), and a negative correlation between adiponectin concentration and fat mass (r = - 0.23; P = 0.02).ConclusionInflammatory and angiogenesis activation was found in RA patients with all types of body composition, but only in those with obesity and overweight there was a direct antagonism between adiponectin and VEGF. Further research is needed to identify possible regimens of metabolic correction in different variations of body composition.

Genetic Background of Hypertension in Connective Tissue Diseases

“…In our study, body mass, LBM, and BMI values were comparable between CTD and control groups. Similarly, other studies have not shown differences in fatfree mass (LBM) and fat mass between patients with rheumatoid arthritis and control groups if the groups have comparable BMI within the recommended range (<25 kg/m 2 ) [30,31]. But in our study, patients with CTD were characterized by higher water content, serum glucose, and triglyceride level when compared to healthy subjects.…”

Disease–Drug Interactions in Inflammatory States via Effects on CYP‐Mediated Drug Clearance

“…29 In addition to IL-6 concentrations increasing with disease severity, Il-6 concentrations are dependent on circadian variation and on body weight. 51 In 2000, the pharmacokinetics of the S-and R-enantiomers of verapamil were compared in 8 RA patients with 8 age-and sex-matched healthy volunteers. 10 Verapamil is a major substrate of CYP3A and a minor substrate of CYP1A2, CYP2B6, CYP2C9, and CYP2E1.…”

Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus

“…One of the hormones secreted by adipocytes is adiponectin. It is one of the main regulators of carbohydrate and fat exchange, produced exclusively in fat tissue [Oranskiy et al, ] Obesity is associated with a decrease in circulating adiponectin [Kiortsis et al, ] but while weight loss has been shown to increase adiponectin, there are conflicting results [Christou et al, ]. This may be because there are several multimeric forms of adiponectin that circulate in humans [Waki et al, ] and rhesus monkeys [Bobbert et al, ].…”