Body composition and pelvic fat distribution are associated with prostate cancer aggressiveness and can predict biochemical recurrence

Abstract

This study evaluated the effect of body composition and pelvic fat distribution on the aggressiveness and prognosis of localized prostate cancer. This study included patients who underwent robot-assisted radical prostatectomy with positive surgical margins. Clinicodemographic data were collected from patients' medical reports. Pretreatment magnetic resonance images (MRI) obtained for cancer staging were reviewed by a single radiologist to calculate pelvic fat distribution and body composition. We correlated these body composition parameters with initial prostate-specific antigen (iPSA), Gleason score, extracapsular tumor extension, and biochemical recurrence (BCR)-free survival. The iPSA was significantly associated with body mass index (BMI; P = .027), pelvic fat volume (P = .004), and perirectal fat volume (P = .001), whereas the Gleason score was significantly associated with BMI only (P = .011). Tumor extracapsular extension was significantly associated with increased periprostatic fat volume (P = .047). Patients with less subcutaneous fat thickness (<2.4 cm) had significantly poor BCR-free survival (P = .039). Pelvic fat distribution, including pelvic fat volume, perirectal fat volume, and periprostatic fat volume, were significantly correlated with prostate cancer aggressiveness. Patients with less subcutaneous fat had an increased risk of BCR after radical prostatectomy.

Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients

“…( 58 ) reported 12% of cases in GG1 and 29% for GG4/5, Chien et al. ( 59 ) reported 35% of the cases in GG1, which resembles the distribution in our study with 34.8% of cases in GG1. However, Chien et al.…”

“…The distribution of Gleason GG found in our patients is variable compared to other studies with patients bearing localized PC tumors. While Zimmermann et al (58) reported 12% of cases in GG1 and 29% for GG4/5, Chien et al (59) reported 35% of the cases in GG1, which resembles the distribution in our study with 34.8% of cases in GG1. However, Chien et al also reported 20% of cases in GG4/5, differing from our 6.5% for the same group.…”

Measurements of peri-prostatic adipose tissue by MRI predict bone metastasis in patients with newly diagnosed prostate cancer

“…and Grading groups (C). these two parameters were associated with biochemical recurrence, Grading groups progression, and the time to castration resistant prostate cancer (19,23,(35)(36)(37). However, little is known about its potential role in predicting bone metastasis.…”