Body composition and clinical symptoms in patients with hip or knee osteoarthritis: Results from the KHOALA cohort

Jeanmaire, Clémence; Mazières, B; Verrouil, Évelyne; Bernard, Laure; Guillemin, Françis; Rat, Anne‐Christine

doi:10.1016/j.semarthrit.2017.10.012

Cited by 30 publications

(39 citation statements)

References 42 publications

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“…Only few cross-sectional studies have used more sophisticated methods to assess adiposity. In a study among 40-75 year-old adults with hip or knee osteoarthritis, higher fat mass index, assessed by using DXA, was associated with lower SF-36 physical health summary score [40]. A population-based study among older men reported associations between SF-36 and multiple anthropometric/ body composition measures.…”

Section: Discussionmentioning

confidence: 98%

“…Further, a study comparing obese older adults and non-obese, non-frail older adults reported that obese older adults had lower scores in mental HRQoL than non-obese non-frail older adults [45]. However, only [40]. However, fat-free mass index or indicators of fat mass were not associated with mental HRQoL.…”

Section: Discussionmentioning

confidence: 98%

“…Glintborg et al reported no associations between absolute lean body mass and SF-36 domains in older men [25]. Furthermore, in older adults with hip or knee osteoarthritis, fat-free mass index or appendicular lean mass (ALM) to BMI ratio were not significantly associated with SF-36 physical component summary score [40]. However, low muscle mass was associated with a general HRQoL index, EQ-5D index score, as well as mobility, self-care, and usual activities dimensions of EQ-5D among older Korean men [24].…”

Section: Discussionmentioning

confidence: 99%

“…Higher lean mass index was only associated with better general health and a higher physical component score at baseline. Although several cross-sectional studies have examined the relationships between body composition and HRQoL in older adults [23][24][25]40], only few have utilized a longitudinal design. In the present study, several domains of HRQoL declined in all four body composition categories over the 10-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Body composition and changes in health-related quality of life in older age: a 10-year follow-up of the Helsinki Birth Cohort Study

et al. 2020

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Purpose Most studies examining the associations between body composition and health-related quality of life (HRQoL) in older age have been cross-sectional and analyzed only fat or lean mass. Hence, it is poorly known whether fat and lean mass are independently associated with subsequent changes in HRQoL. We investigated whether baseline lean and fat mass are associated with changes in HRQoL over a 10-year period in older adults. Methods We studied 1044 men and women from the Helsinki Birth Cohort Study (age 57-70 years at baseline). Bioelectrical impedance analysis was used to derive baseline fat mass index (FMI, fat mass/height 2) and lean mass index (lean mass/ height 2), dichotomized at sex-specific medians. HRQoL was assessed using RAND 36-item Health Survey at baseline and follow-up 10 years later. Results When controlled for lean mass and adjusted for potential confounders, high baseline FMI was associated with a greater decline in general health (standardized regression coefficient [β] = − 0.13, p = 0.001), physical functioning (β = − 0.11, p = 0.002), role physical (β = − 0.13, p = 0.003), vitality (β = − 0.08, p = 0.027), role emotional (β = − 0.12, p = 0.007), and physical component score (β = − 0.14, p < 0.001). High baseline FMI was also associated with low HRQoL in all physical domains at baseline (β: from − 0.38 to − 0.10). Lean mass was not strongly associated with HRQoL at baseline or change in HRQoL. Conclusion In older community-dwelling adults, higher fat mass is, independent of lean mass, associated with lower physical HRQoL and greater decline in HRQoL. Prevention of adiposity may contribute to preservation of a good quality of life in older age.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Body composition and changes in health-related quality of life in older age: a 10-year follow-up of the Helsinki Birth Cohort Study

et al. 2020

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“…Sarcopenia and obesity were frequently reported, affecting 22% to 30% of the patients with OA [35,36]. An increased risk of myocardial infarction, stroke and metabolic syndrome was also reported as well as atherogenic lipid profile, elevated fasting glucose [37].…”

Section: Cardiometabolic Comorbidities In Other Rheumatic Diseasesmentioning

confidence: 99%

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

2020

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a high prevalence of death due to cardiometabolic diseases. As observed during the aging process, several comorbidities, such as cardiovascular disorders (CVD), insulin resistance, metabolic syndrome and sarcopenia, are frequently associated to RA. These abnormalities could be closely linked to alterations in lipid metabolism. Indeed, RA patients exhibit a lipid paradox, defined by reduced levels of total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol whereas the CVD risk is increased. Moreover, the accumulation of toxic lipid mediators (i.e., lipotoxicity) in skeletal muscles can induce mitochondrial dysfunctions and insulin resistance, which are both crucial determinants of CVD and sarcopenia. The prevention or reversion of these biological perturbations in RA patients could contribute to the maintenance of muscle health and thus be protective against the increased risk for cardiometabolic diseases, dysmobility and mortality. Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Thereby, dietary supplementation with omega 3 FA should be a promising strategy to counteract muscle lipotoxicity and for the prevention of comorbidities in RA patients.

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Where Two Common Conditions of Aging Meet: Osteoarthritis and Sarcopenia

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2020

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Body composition and clinical symptoms in patients with hip or knee osteoarthritis: Results from the KHOALA cohort

Cited by 30 publications

References 42 publications

Body composition and changes in health-related quality of life in older age: a 10-year follow-up of the Helsinki Birth Cohort Study

Body composition and changes in health-related quality of life in older age: a 10-year follow-up of the Helsinki Birth Cohort Study

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

Where Two Common Conditions of Aging Meet: Osteoarthritis and Sarcopenia

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