Body composition, aerobic capacity, and density of muscle capillaries in young and old men.

Pařízková, J; Eiselt, E; Sprynarová, S; Wachtlová, M

doi:10.1152/jappl.1971.31.3.323

Cited by 70 publications

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“…Even so, some studies indicate a superfluous capillary supply in old rodent muscles, where there were no differences in capillary density and capillary‐to‐fibre ratio, despite a reduction in the oxidative capacity,11 or even a higher capillary density, with similar oxidative capacity, than in young rats 12. There are indications that these relationships may also change in human muscle as the relationship between maximum oxygen uptake and oxygen kinetics with capillarization in young people has disappeared in old men 13, 14…”

Section: Introductionmentioning

confidence: 99%

Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging

Barnouin

McPhee

Butler-Browne

et al. 2017

J cachexia sarcopenia muscle

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BackgroundAs muscle capillarization is related to the oxidative capacity of the muscle and the size of muscle fibres, capillary rarefaction may contribute to sarcopenia and functional impairment in older adults. Therefore, it is important to assess how ageing affects muscle capillarization and the interrelationship between fibre capillary supply with the oxidative capacity and size of the fibres.MethodsMuscle biopsies from healthy recreationally active young (22 years; 14 men and 5 women) and older (74 years; 22 men and 6 women) people were assessed for muscle capillarization and the distribution of capillaries with the method of capillary domains. Oxidative capacity of muscle fibres was assessed with quantitative histochemistry for succinate dehydrogenase (SDH) activity.ResultsThere was no significant age‐related reduction in muscle fibre oxidative capacity. Despite 18% type II fibre atrophy (P = 0.019) and 23% fewer capillaries per fibre (P < 0.002) in the old people, there was no significant difference in capillary distribution between young and old people, irrespective of sex. The capillary supply to a fibre was primarily determined by fibre size and only to a small extent by oxidative capacity, irrespective of age and sex. Based on SDH, the maximal oxygen consumption supported by a capillary did not differ significantly between young and old people.ConclusionsThe similar quantitative and qualitative distribution of capillaries within muscle from healthy recreationally active older people and young adults indicates that the age‐related capillary rarefaction, which does occur, nevertheless maintains the coupling between skeletal muscle fibre size and capillarization during healthy ageing.

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Section: Introductionmentioning

confidence: 99%

Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging

Barnouin

McPhee

Butler-Browne

et al. 2017

J cachexia sarcopenia muscle

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“…In contrast, structural data on muscle capacity for O 2 transfer from capillary to fiber mitochondria have been contradictory. Human and/or animal studies have shown decreased (5,12,14,38), unchanged (3,4,36), or even increased (8,19,36) capillary-to-fiber number ratios in skeletal muscles with aging. Part of the discrepancies have been attributed to the fact that differences in activity levels among subjects can offset age-related effects (4), and a greater percentage of aerobic fibers (as IIb fibers are lost) can also explain greater capillarities in specific muscles with aging (36).…”

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confidence: 99%

Greater capillary-fiber interface per fiber mitochondrial volume in skeletal muscles of old rats

Mathieu-Costello¹,

Yan²,

Trejo-Morales³

et al. 2005

Journal of Applied Physiology

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The objective was to examine whether muscle structural capacity for O2 flux (i.e., capillary-to-fiber surface ratio) relative to fiber mitochondrial volume deteriorates with the muscle atrophy of aging in predominantly slow-(soleus, S) and fast-twitch (extensor digitorum longus, EDL) muscles of old (24 mo) and very old (35 mo) F344BN rats compared with adult (12 mo old). Wet muscle mass decreased 29% (196 Ϯ 4 to 139 Ϯ 5 mg) in S and 22% (192 Ϯ 3 to 150 Ϯ 3 mg) in EDL between 12 and 35 mo of age, without decline in body mass. Capillary density increased 65% (1,387 Ϯ 54 to 2,291 Ϯ 238 mm Ϫ2 ) in S and 130% (964 Ϯ 95 to 2,216 Ϯ 311 mm Ϫ2 ) in EDL, because of the muscle fiber atrophy, whereas capillary per fiber number remained unchanged. Altered capillary geometry, i.e., lesser contribution of tortuosity and branching to capillary length, was found in S at 35 compared with 12 and 24 mo, and not in EDL. Accounting for capillary geometry revealed 55% (1,776 Ϯ 78 to 2,750 Ϯ 271 mm Ϫ2 ) and 113% (1,194 Ϯ 112 to 2,540 Ϯ 343 mm Ϫ2 ) increases in capillary length-to-fiber volume ratio between 12 and 35 mo of age in S and EDL, respectively. Fiber mitochondrial volume density was unchanged over the same period, causing mitochondrial volume per micrometer fiber length to decrease in proportion to the fiber atrophy in both muscles. As a result of the smaller fiber mitochondrial volume in the face of the unchanged capillary-to-fiber number ratio, capillaryto-fiber surface ratio relative to fiber mitochondrial volume not only did not deteriorate, but in fact increased twofold in both muscles between 12 and 35 mo of age, independent of their different fiber type. capillary anisotropy; morphometry; ultrastructure; sarcopenia THE REDUCTION IN MUSCLE MAXIMAL capacity for aerobic work with aging is well known, and previous studies have shown alterations in both convective and diffusive components of O 2 transport in muscles. For example, reduced leg blood flow and increased leg O 2 extraction were found in older (63 Ϯ 2 yr old) compared with younger (27 Ϯ 1 yr old) endurance-trained men during submaximal exercise (42), and blood flow redistribution from highly oxidative to highly glycolytic muscles was recently demonstrated in the hindlimb of old (27-29 mo old) compared with young (6 -8 mo old) F344BN rats during submaximal exercise (37). Using an in situ pump-perfused hindlimb preparation to match convective O 2 delivery and eliminate age-related decline in blood flow, Hepple et al. (15) found a 22% decrease in the mass-specific O 2 uptake of the distal hindlimb in late middle aged (28 -39 mo) compared with young adult (8 mo) F344BN rats. In contrast, structural data on muscle capacity for O 2 transfer from capillary to fiber mitochondria have been contradictory. Human and/or animal studies have shown decreased (5, 12, 14, 38), unchanged (3, 4, 36), or even increased (8, 19, 36) capillary-to-fiber number ratios in skeletal muscles with aging. Part of the discrepancies have been attributed to the fact that differences in activit...

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“…Los métodos de determinación de la composición corporal existentes en la actualidad permiten determinan el valor total de los componentes corporales, sean estos de masa adiposa, muscular, ósea, residual y piel (Matiegka, 1921;Behnke, 1942;Brozek et al, 1963;Siri, 1961;Parizkova et al, 1971;Würch, 1974;Rocha, 1975;Jackson & Pollock, 1978;Lohman, 1981;Drinkwater, 1984a;Kerr, 1988), pero no definen la distribución de los componentes en el cuerpo.…”

Section: Introductionunclassified

Estimación y Comparación de la Masa Muscular por Segmento, en Deportistas Juveniles Chilenos

et al. 2014

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RESUMEN:El objetivo de este trabajo fue determinar y comparar la composición corporal de deportistas chilenos juveniles destacados, pertenecientes a las selecciones nacionales en el año 2011, de diferentes disciplinas deportivas mediante métodos antropométricos. Fueron evaluados 4 grupos de deportistas juveniles de alto rendimiento, con un número total de 92 individuos, pertenecientes a las disciplinas de lucha olímpica, halterofilia, básquetbol y fútbol. La Masa Muscular de los miembros superiores (MMES) es mayor en basquetbolistas y Halterofilistas con 7,49 (±1,25) y 7,50 (±2,54) kg respectivamente, al ser comparado con futbolistas, quienes obtuvieron un promedio de 5,27 (±0,37) kg. Por otra parte la lucha olímpica posee un promedio de masa muscular de 6,46 (±1,50) kg, la cual está por debajo de los basquetbolistas y Halterofilistas, debido a que la utilización de los miembros superiores es menor que en las disciplinas anteriormente mencionadas, pero a su vez, es mayor que la de los futbolistas. No se aprecian diferencias importantes en la masa muscular total, pero que son marcadas en la masa muscular por segmentos. Concluimos que la estimación de la masa muscular total, no es un elemento suficiente para determinar y predecir el rendimiento deportivo de los sujetos, a diferencia de la segmentación de la masa muscular que permite comparar de mejor forma, la manera en que se distribuye este componente en las distintas disciplinas deportivas, mejorando la especificidad del conocimiento.PALABRAS CLAVE: Composición corporal; Masa muscular total; Masa muscular por segmentos. INTRODUCCIÓNCada especialidad deportiva tiene definido un patrón de cineantropometría específico (Villa et al., 1992), en el cual las características físicas están ligadas al rendimiento deportivo y a la asociación que se puede establecer entre la distribución de los componentes morfoestructurales (grasa, músculo, hueso, etc) (Barraza et al., 2009).Los métodos de determinación de la composición corporal existentes en la actualidad permiten determinan el valor total de los componentes corporales, sean estos de masa adiposa, muscular, ósea, residual y piel (Matiegka, 1921;

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Body composition, aerobic capacity, and density of muscle capillaries in young and old men.

Cited by 70 publications

References 0 publications

Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging

Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging

Greater capillary-fiber interface per fiber mitochondrial volume in skeletal muscles of old rats

Estimación y Comparación de la Masa Muscular por Segmento, en Deportistas Juveniles Chilenos

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