Body cell mass repletion and improved quality of life in HIV‐infected individuals receiving oxandrolone

Earthman, Carrie P.; Reid, Phyllis M.; Harper, Ingeborg T.; Ravussin, Éric; Howell, Wanda H.

doi:10.1177/0148607102026006357

Cited by 31 publications

(10 citation statements)

References 25 publications

(44 reference statements)

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“…14,15 Most studies of the efficacy of the oral androgen, oxandrolone (OX), have been small, observational, or remain unpublished. [16][17][18][19] The only published randomized clinical trial of OX alone was conducted early in the epidemic for persons with wasting and significant muscle weakness. 20 In this group with myopathy, weight increased with the use of OX but strength did not and there were no measures of body composition.…”

mentioning

confidence: 99%

A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting

Shevitz

Wilson

McDermott

et al. 2005

JAIDS Journal of Acquired Immune Deficiency Syndromes

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mentioning

confidence: 99%

A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting

Shevitz

Wilson

McDermott

et al. 2005

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…The internal consistency of the total scale in these studies was invariably excellent (Cronbach’s α range 0.91–0.92) [17, 22, 30–32]. The subscale α coefficients ranged from 0.72–0.92 with the exception of the cognitive function (CF) domain in two studies from South Africa whose α coefficients were slightly below the recommended 0.70 (Cronbach’s α values of 0.65 and 0.60) [13, 17, 22, 30–33]. None of these seven studies reported the test-retest reliability of the FAHI.…”

Section: Resultsmentioning

confidence: 99%

A mixed methods approach to adapting and evaluating the functional assessment of HIV infection (FAHI), Swahili version, for use with low literacy populations

et al. 2017

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BackgroundDespite bearing the largest HIV-related burden, little is known of the Health-Related Quality of Life (HRQoL) among people living with HIV in sub-Saharan Africa. One of the factors contributing to this gap in knowledge is the lack of culturally adapted and validated measures of HRQoL that are relevant for this setting.AimsWe set out to adapt the Functional Assessment of HIV Infection (FAHI) Questionnaire, an HIV-specific measure of HRQoL, and evaluate its internal consistency and validity.MethodsThe three phase mixed-methods study took place in a rural setting at the Kenyan Coast. Phase one involved a scoping review to describe the evidence base of the reliability and validity of FAHI as well as the geographical contexts in which it has been administered. Phase two involved in-depth interviews (n = 38) to explore the content validity, and initial piloting for face validation of the adapted FAHI. Phase three was quantitative (n = 103) and evaluated the internal consistency, convergent and construct validities of the adapted interviewer-administered questionnaire.ResultsIn the first phase of the study, we identified 16 studies that have used the FAHI. Most (82%) were conducted in North America. Only seven (44%) of the reviewed studies reported on the psychometric properties of the FAHI. In the second phase, most of the participants (37 out of 38) reported satisfaction with word clarity and content coverage whereas 34 (89%) reported satisfaction with relevance of the items, confirming the face validity of the adapted questionnaire during initial piloting. Our participants indicated that HIV impacted on their physical, functional, emotional, and social wellbeing. Their responses overlapped with items in four of the five subscales of the FAHI Questionnaire establishing its content validity. In the third phase, the internal consistency of the scale was found to be satisfactory with subscale Cronbach’s α ranging from 0.55 to 0.78. The construct and convergent validity of the tool were supported by acceptable factor loadings for most of the items on the respective sub-scales and confirmation of expected significant correlations of the FAHI subscale scores with scores of a measure of common mental disorders.ConclusionThe adapted interviewer-administered Swahili version of FAHI questionnaire showed initial strong evidence of good psychometric properties with satisfactory internal consistency and acceptable validity (content, face, and convergent validity). It gives impetus for further validation work, especially construct validity, in similar settings before it can be used for research and clinical purposes in the entire East African region.

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“…The variations with time of FFM, ECW and TBW measured by Tefal and Xitron in AN subjects during monitoring for periods of several weeks were in good agreement. While the BCM is a good indicator of nutritional status [22], it is important to normalize it with respect to H 2 in order to discriminate between AN subjects and a normal population independently of their age.…”

Section: Discussionmentioning

confidence: 99%

Assessment of body composition in adolescent subjects with anorexia nervosa by bioimpedance

Moreno

Djeddi

Jaffrin

2008

Medical Engineering & Physics

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Body cell mass repletion and improved quality of life in HIV‐infected individuals receiving oxandrolone

Cited by 31 publications

References 25 publications

A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting

A Comparison of the Clinical and Cost-Effectiveness of 3 Intervention Strategies for AIDS Wasting

A mixed methods approach to adapting and evaluating the functional assessment of HIV infection (FAHI), Swahili version, for use with low literacy populations

Assessment of body composition in adolescent subjects with anorexia nervosa by bioimpedance

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