Body builder: from synthetic cells to engineered tissues

Hu, Shiqi; Ogle, Brenda M.; Cheng, Ke

doi:10.1016/j.ceb.2018.04.010

Cited by 17 publications

(13 citation statements)

References 34 publications

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“…6c-h). We and others have demonstrated that the cell-free secretome derived from stem cells can achieve a level of protection and regeneration similar or superior to the cells themselves 4,[26][27][28][29] . Our observations showed that LSC-Sec was capable of reversing fibrosis caused by Bleo or silica particles (Figs.…”

Section: Discussionmentioning

confidence: 98%

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

et al. 2020

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Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different models of lung injury and fibrosis. Analysis reveals that LSC-Sec and LSC-Exo treatments could attenuate and resolve bleomycin-and silica-induced fibrosis by reestablishing normal alveolar structure and decreasing both collagen accumulation and myofibroblast proliferation. Additionally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived from mesenchymal stem cells in some measures. We showed that an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis.

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Section: Discussionmentioning

confidence: 98%

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

et al. 2020

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“…Despite several advantages offered by in vitro/ ex vivo approaches, there are limitations to experimental reproducibility due to variations in human tissues/cells, obtaining tissues from individuals with underlying diseases, the limited availability of human tissues, and the interlaboratory differences in cell culture protocols, particularly involving 3D models [147]. With the incorporation of tissue printing technologies and the greater understanding of stem cell biology, the development of labgrown, standardized human tissues may not be too far in the future [157,158].…”

Section: In Vitro Modelsmentioning

confidence: 99%

Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

Tanner

Single

2019

J Innate Immun

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Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide. COPD is incurable, with current treatments only addressing associated symptoms and sometimes slowing its progression, thus highlighting the need to develop novel treatments. However, this has been limited by the lack of experimental standardization within the respiratory disease research area. A lack of coherent animal models that accurately represent all aspects of COPD clinical presentation makes the translation of promising in vitro data to human clinical trials exceptionally challenging. Here, we review current knowledge within the COPD research field, with a focus on current COPD animal models. Moreover, we include a set of advantages and disadvantages for the selection of pre-clinical models for the identification of novel COPD treatments.

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“…A number of improvements and additions, based on previous cell delivery strategies, demonstrate better stem cell retention and promotion of endometrial repair after trauma . However, low retention and the propensity for tumorigenicity after administration still remain major obstacles for stem cell–based therapy …”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

Liu

Yang

et al. 2019

Adv Healthcare Materials

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117

108

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Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk of tumor formation, low engraftment rates, as well as storage and transportation logistics. While attempts have been made to curb these issues, there remains a need for simple and effective solutions. A growing body of evidence supports the theory that delivering media, conditioned with mesenchymal stem cells, might be a promising alternative to live cell therapy. Mesenchymal stem cell‐secretome (MSC‐Sec) has a superior safety profile and can be stored without losing its regenerative properties. It is versatile enough to be added to a number of delivery vehicles that improve engraftment and control the release of the therapeutic. Thus, it holds great potential for the treatment of AS. Here, a new strategy for loading crosslinked hyaluronic acid gel (HA gel) with MSC‐Sec is reported. The HA gel/MSC‐Sec treatment paradigm creates a sustained release system that repairs endometrial injury in rats and promotes viable pregnancy.

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Body builder: from synthetic cells to engineered tissues

Cited by 17 publications

References 34 publications

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome

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