Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle‐aged adults at risk of Alzheimer's disease

Anstey, Kaarin J.; Bahar‐Fuchs, Alex; Herath, Pushpani; Kim, Sarang; Burns, Richard A.; Rebok, George W.; Cherbuin, Nicolas

doi:10.1016/j.trci.2015.04.003

Cited by 47 publications

(79 citation statements)

References 19 publications

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“…Sample size calculations were undertaken using G*Power (version 3.1.9.2; http://www.gpower.hhu.de/en.html ). To detect a medium effect size, which was based on the previous Body Brain Life (BBL; Trial ID: ACTRN12612000147886) [ 28 , 29 ]) study, in one control and three experimental conditions with a 5% risk of type 1 error (α) and 95% power, a total sample size of 280 persons is required. We are collecting 500 participants at baseline with a 40% dropout rate in mind at the follow-up assessment.…”

Section: Methods and Analysismentioning

confidence: 99%

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Dementia Stigma Reduction (DESeRvE): Study protocol for a randomized controlled trial of an online intervention program to reduce dementia-related public stigma

Kim

Werner

Richardson

et al. 2019

Contemporary Clinical Trials Communications

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Background Dementia is considered to be a highly stigmatized condition leading to significant negative effects on the health and well-being of people with dementia and people supporting someone living with dementia. Even though there has been an increasing amount of research on dementia-related stigma over the past two decades, research on effective, evidence-based approaches to reduce dementia-related public stigma is still lacking. Methods A 2 × 2 factorial randomized controlled trial (RCT) is being conducted to evaluate the feasibility and short-term efficacy of an online intervention program. It compares different approaches to reduce dementia-related public stigma: 1) Education (ED) that is designed to provide written information on dementia; 2) Contact (CT) that is designed to offer indirect virtual contact with people with dementia and/or people supporting someone with dementia; 3) Education plus contact (ED + CT) that is designed to provide both written information on dementia and indirect virtual contact with people with dementia and/or people supporting someone living with dementia; and 4) an active control condition receiving written information on general health. We aim to recruit 500 lay persons aged 40 and over, to complete a questionnaire measuring the level of dementia-related public stigma, assessed with a modified Attribution Questionnaire and dementia knowledge, assessed with the Dementia Knowledge Assessment Scale version 2 at baseline and follow-up assessments (immediately after the intervention and 12 weeks post-intervention). Discussion Results from this trial will provide evidence on the most effective approach in reducing dementia-related public stigma. The results are also likely to form an evidence base for the feasibility of dementia-related public stigma campaigns to educate the general public.

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Section: Methods and Analysismentioning

confidence: 99%

“…The module provides information about dementia in terms of definition, symptoms, pathology, and treatments. The BBL is written in laypersons language and is documented to improve dementia literacy in a RCT [ 29 ]. Information on dementia-related stigma and its impacts have been added to this module.…”

Section: Methods and Analysismentioning

confidence: 99%

Dementia Stigma Reduction (DESeRvE): Study protocol for a randomized controlled trial of an online intervention program to reduce dementia-related public stigma

Kim

Werner

Richardson

et al. 2019

Contemporary Clinical Trials Communications

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“…Based on a previous study, Anstey et al (2015) stated in their findings that the Internet-based intervention was proven to be an effective educational tool where they used the website 'Body Brain Life' (BBL) for creating awareness among subjects in the intervention group on dementia and its risk factors [15]. The subjects in the intervention group were exposed to BBL for 26 weeks and were subsequently assessed using the Australian National University-Alzheimer's Disease Risk Index (ANU-ADRI) screening tool upon the completion of 26 weeks [15]. The study reported a significant increase in dementia risk reduction knowledge among the subjects.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of a Web-Based Health Education Tool, WESIHAT 2.0, among Older Adults: A Randomized Controlled Trial

Vanoh

Shahar

Razali

et al. 2019

JAD

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Background: Intervention strategies, especially online based approaches, are considered to be beneficial in improving the health of the senior. The effectiveness of such approaches is yet to be determined. Objective: This study aims to determine the effectiveness of the web-based application, WESIHAT 2.0©, for improving cognitive function, physical fitness, biochemical indices, and psychosocial variables among older adults in Klang Valley, Malaysia. The cost analysis of WESIHAT 2.0©was also determined. Method: The study utilized a two-arm randomized controlled trial with 25 subjects in each of the intervention and control groups. The participants chosen for the study included those who were 60 years and above with at least secondary education and had internet access using a computer at home. The intervention group was exposed to the website (30 minutes per day, 4 days per week) for six months, while the control group was given health education pamphlets. Activity-Based Costing method was used to determine the cost saved using WESIHAT 2.0©as compared to using the pamphlet. Results: Significant intervention effects were observed for self-perception of disability and informational support scores. WESIHAT 2.0©was able to save costs in improving the self-perception of disability score and the informational support score at MYR 6.92 and MYR 13.52, respectively, compared to the conventional method. Conclusion: WESIHAT 2.0©was able to save costs in improving the self-perceived disability and informational support scores for the intervention group.

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“…The ANU-ADRI was validated on three independent cohorts [7] against the Cardiovascular Risk Factors, Aging and Dementia index and has been proposed as the key risk assessment tool in large-scale dementia prevention trials. ANU-ADRI has already been used in the first online dementia risk reduction trial in Australia [8] , [9] and is currently available to the general public through the ANU-ADRI website ( http://anuadri.anu.edu.au/ ). The website has attracted over 11,700 visitors since its launch early 2014.…”

Section: Introductionmentioning

confidence: 99%

Assessing reliability of short and tick box forms of the ANU‐ADRI: Convenient alternatives of a self‐report Alzheimer's disease risk assessment

Kim

Anstey

2016

A&D Transl Res & Clin Interv

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IntroductionTo assess the reliability of short versions of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI).MethodsA short form of the ANU-ADRI (ANU-ADRI-SF) was developed by assessing risk and protective factors with single questions where possible and with short forms of sub-questionnaires where available. The tick box form of the ANU-ADRI (ANU-ADRI-TB) was developed with unique questions for each risk and protective factor for Alzheimer's disease. The short versions were evaluated in an independent community sample of 504 participants with a mean age of 45.01 (SD = 14.85, range = 18–81).ResultsThe short versions demonstrated high reliabilities when compared with the ANU-ADRI. However, the proportion of misclassification was high for some risk factors and particularly for the ANU-ADRI-TB.DiscussionThe ANU-ADRI-SF may be considered if less reliable questions from the ANU-ADRI-SF can be replaced with more reliable questions from the ANU-ADRI for risk/protective factors with high misclassification.

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Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle‐aged adults at risk of Alzheimer's disease

Cited by 47 publications

References 19 publications

Dementia Stigma Reduction (DESeRvE): Study protocol for a randomized controlled trial of an online intervention program to reduce dementia-related public stigma

Dementia Stigma Reduction (DESeRvE): Study protocol for a randomized controlled trial of an online intervention program to reduce dementia-related public stigma

The Effectiveness of a Web-Based Health Education Tool, WESIHAT 2.0, among Older Adults: A Randomized Controlled Trial

Assessing reliability of short and tick box forms of the ANU‐ADRI: Convenient alternatives of a self‐report Alzheimer's disease risk assessment

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