Objective: To explore the difference of plantar pressure distribution between adolescents with intellectual disabilities (ID) and healthy adolescents during gait and the effect of Swiss ball training on plantar pressure of adolescents with ID during gait.Methods: A total of 12 adolescents with ID participated in a 12-week Swiss ball training (three 40-minute sessions per week), including eight balance training movements. Meanwhile, 10 healthy adolescents did not undergo any intervention. Pre and post-interventions of stride length, stride time, gait speed, relative peak pressure, impulse and gait symmetry of 10 zones of the sole were conducted.Results: Adolescents with ID had shorter stride length, longer stride time, slower walking speed, excessive plantar peak pressure in heel medial zone, obvious abnormalities in metatarsal 1-3 zone, and significantly lower rearfoot impulse and gait symmetry than healthy adolescents. Adolescents with ID demonstrated increased post-intervention stride length, stride time, walking speed, and improved gait symmetry. Additionally, their peak pressure and impulse indexes were closer to those of healthy adolescents after the intervention.Conclusion: Abnormal gait phenomena, such as peak pressure, impulse, and gait asymmetry were observed in adolescents with an intellectual disability. Swiss ball training can make plantar pressure distribution more reasonable and improve abnormal gait among adolescents with ID.