BODIPY-embedded electrospun materials in antimicrobial photodynamic inactivation

Stoll, Kevin; Scholle, Frank; Zhu, Jiadeng; Zhang, Xiangwu; Ghiladi, Reza A.

doi:10.1039/c9pp00103d

Cited by 42 publications

(39 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Novel nanofibers with embedded BODIPYs showed potential in inactivation of methicillin‐resistant S. aureus , vancomycin‐resistant E. faecium , multidrug‐resistant A. baumannii , and vesicular stomatitis virus. Thus such materials have much potential for the preparation of various self‐sterilizing surfaces [26] . An interesting study has been reported by Tekdaş et al, who prepared mono‐quaternized BODIPY derivative with 4‐(trimethylammonium)phenyl group.…”

Section: Resultsmentioning

confidence: 99%

“…Thus such materials have much potential for the preparation of various self-sterilizing surfaces. [26] An interesting study has been reported by Tekdaş et al, who prepared mono-quaternized BODIPY derivative with 4-(trimethylammonium)phenyl group. This compound has been tested as a regular antibacterial agent, without the exposure to light, and revealed high efficiency against methicillin-resistant Staphylococcus species.…”

Section: In Vitro Photodynamic Inactivation Of Planktonic Bacteriamentioning

confidence: 99%

“…Not many reports concerning cationic BODIPY derivatives with photodynamic activity have been published so far. Cationic BODIPYs with trimethylammonium and pyridinium substituents have revealed promising photoinactivation activity against both Gram‐positive and Gram‐negative bacteria [24–26] . Noteworthy, BODIPY dye possessing a positively charged, quaternized 1,3‐thiazole ring, and galactose moiety has shown high effectivity and selectivity toward bacterial biofilm over mammalian cells [27] .…”

Section: Introductionmentioning

confidence: 99%

“…Cationic BODIPYs with trimethylammonium and pyridinium substituents have revealed promising photoinactivation activity against both Gram-positive and Gram-negative bacteria. [24][25][26] Noteworthy, BODIPY dye possessing a positively charged, quaternized 1,3thiazole ring, and galactose moiety has shown high effectivity and selectivity toward bacterial biofilm over mammalian cells. [27] On the other hand, the activity of cationic BODIPYs against cancer cells has also been reported.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

BODIPY‐Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect

et al. 2020

View full text Add to dashboard Cite

Boron‐dipyrromethene derivatives, including cationic and iodinated analogs, were obtained and subjected to physicochemical and in vitro photodynamic activity studies. Iodinated derivatives revealed a substantial heavy atom effect manifested by a bathochromic shift of the absorption band by about 30 nm and fluorescence intensity reduced by about 30–35 times, compared to that obtained for non‐iodinated ones. In consequence, singlet oxygen generation significantly increased with ΦΔ values in the range 0.69–0.97. The in vitro photodynamic activity was evaluated on Gram‐positive Staphylococcus aureus, Gram‐negative Escherichia coli, and on human androgen‐sensitive prostate adenocarcinoma cells (LNCaP). The novel cationic, iodinated BODIPY, demonstrated the highest activity toward all studied cells. An excellent cytotoxic effect was found against LNCaP cells with an IC50 value of 19.3 nM, whereas the viability of S. aureus was reduced by >5.6 log10 at 0.25 μM concentration and by >5.3 log10 in the case of E. coli at 5 μM. Thus, this analog seems to be a very promising candidate for the application in both anticancer and antimicrobial photodynamic therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Photodynamic Inactivation Of Planktonic Bacteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

BODIPY‐Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is important to immobilise the photosensitiser on a support as this would eliminate the need to remove the sensitiser from water post-irradiation, but the immobilisation should not compromise the photosensitisation of ROS. 38,39 Several organic photosensitisers, including BODIPY-derivatives immobilised on Nylon or polyacrylonitrile nanofibers, 40 porphyrin derivatives immobilised on polyethylene elastomer or nanofibrillated cellulose (NFC) have shown efficient killing of bacteria, viruses, and other pathogens, often with 6 log 10 efficiency, primarily on surfaces. 41,42 A summary of the currently available immobilised photosensitisers is given in Table S9 in the ESI, † with the most relevant ones being used for comparison in the discussion section below.…”

Section: Introductionmentioning

confidence: 99%

Cu(i) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light

et al. 2020

View full text Add to dashboard Cite

show abstract

Developments of Advanced Electrospinning Techniques: A Critical Review

Zhu

Cheng

et al. 2021

Adv Materials Technologies

Self Cite

212

101

View full text Add to dashboard Cite

Among currently available nanostructured materials, ultrafine nanofibers, carrying a range of novel physical and chemical properties, have attracted considerable attention in overcoming many limitations present in their corresponding macroscales. [14][15][16][17][18][19] Different strategies have been created and developed for nanofibers fabrication, including thermal-induced phase separation, drawing, template synthesis, and self-assembly, among which electrospinning is of considerable significance as a rapid, simple, and continuous process in manufacturing nanofibers, as well as formulating their 2D and 3D structures. [20][21][22][23][24][25][26] Besides, this straightforward, continuous, and cost-effective method can launch ultrathin nanofibers from an enormous number of materials, including polymers, inorganic ceramics, and composites. [27][28][29][30][31][32] Moreover, electrospun nanofibers and their assemblies are much more favorable in providing high specific surface area, large surface-to-volume ratio, tunable porosity with uniform pores distribution, and the ability of desired chemical functionalization for various applications. [33][34][35][36][37][38][39][40] This review aims to provide comprehensive and critical aspects related to recent developments in electrospinning Electrospinning, considered as a low-cost and straightforward approach, attracts tremendous attention because nanofibrous materials with functional properties prepared by it can be widely applied in numerous fields, including rechargeable batteries, filtration, and distillation. This paper aims to provide a comprehensive review of the latest advances in developing this unique technique, which starts with a brief introduction of the advantages of electrospinning and highlights ongoing research activities, followed by its principles and progress. Afterward, the corresponding properties of electrospun nanofibers are discussed. A future vision regarding challenges and perspectives in this area is proposed at the end. It is believed that this review would provide an extensive and comprehensive reference to utilize this advanced technique to generate novel nanofibers performing in high demanding areas.

show abstract

BODIPY-embedded electrospun materials in antimicrobial photodynamic inactivation

Abstract: Electrospun BODIPY(+)-embedded nanofiber materials were capable of the detection-level photodynamic inactivation of drug-resistant Gram-positive and Gram-negative bacteria and viruses.

Cited by 42 publications

References 52 publications

BODIPY‐Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect

BODIPY‐Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect

Cu(i) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light

Developments of Advanced Electrospinning Techniques: A Critical Review

Contact Info

Product

Resources

About