BODIPY-based photosensitizers with simultaneous photodynamic antitumor and antibacterial effects

Abstract

We present here five BODIPY-based nano-photosensitizers through a supramolecular self-assembly strategy that can achieve photodynamic antitumor and antibacterial therapy simultaneously to improve the prognosis of surgical tumor resection.

Poly(Photosensitizer-Prodrug) Unimolecular Micelles for Chemo-Photodynamic Synergistic Therapy of Antitumor and Antibacteria

“…aureus and E. coli are based on their outer membrane structures . Overall, βPECP1 and βPECP2 demonstrated promising potential for combinatorial therapy, which was due to the synergistic effect of 1 O 2 produced by the photosensitizer monomers and the drugs.…”

“…Additionally, the differences in killing effects of micelles on S. aureus and E. coli are based on their outer membrane structures. 54 Overall, βPECP1 and βPECP2 demonstrated promising potential for combinatorial therapy, which was due to the synergistic effect of 1 O 2 produced by the photosensitizer monomers and the drugs. Future studies could explore optimization strategies such as increasing effective concentrations and coculture durations to enhance antibacterial effects.…”

Carbonylation as a Key Step in New Tandem Reactions – A Route to BODIPYs

“…[1] Since then, BODIPYs found a wide applicability including biochemistry, materials science, engineering, physics, organic electronics, therapeutic applications such as photodynamic therapy etc. [2][3][4][5][6][7][8][9][10][11] The popularity of BODIPY dyes can be attributed to their extraordinary optical properties, which include strong absorption and fluorescence in the UV/vis, combined with high fluorescence quantum yields and high molecular extinction coefficients. They are also highly stable against pH, light and temperature, and can be easily postfunctionalized to tailor their electronic and optical properties.…”

Near-infrared BODIPY photosensitizers for two-photon excited singlet oxygen generation and tumor cell photodynamic therapy

“…In recent years, photodynamic therapy, as a promising therapeutic method, has attracted much attention in the field of tumor treatment and disease diagnosis. 1–5 BODIPYs are an important class of photosensitizer small molecules, which have been widely used in the fields of bioimaging 6,7 and photodynamic therapy 8–12 due to their stable structures and good optical properties. However, in spite of their excellent properties, BODIPY-based photosensitizers still suffer from short absorption wavelengths, poor biocompatibility, and lack of targeting to tumors and tumor organelles, which can be further improved.…”