BODIPY-based metal–organic frameworks as efficient electrochemiluminescence emitters for telomerase detection

Xu, Zhiyuan; Wu, Fan; Zhu, Da; Fu, Haomin; Shen, Zhen; Lei, Jianping

doi:10.1039/d2cc04722e

Cited by 8 publications

(8 citation statements)

References 41 publications

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“…Typically, tetrakis(4-carboxyphenyl) porphyrin with strong optical absorption and emission and distinctive electrochemical properties can be integrated into the framework to form porphyrin-based Zr-MOFs, which can overcome the aggregation-caused quenching effect and thus show great potential in ECL biosensing . Considering the high fluorescence intensity and narrow absorption/emission peaks, the integration of boron dipyrromethene (BDP) into frameworks can separate the aggregated BDP molecules, and thus 24-fold enhancement of ECL intensity is obtained due to the suppressed nonradiative energy dissipation . Furthermore, using hydroquinone and phenanthroline as redox couples, an electroactive MOF (E-MOF) with a one-dimensional zigzag chain is designed as an efficient crystalline ECL emitter in an aqueous medium (Figure A).…”

Section: Structural Design Of Reticular Ecl Nanoemittersmentioning

confidence: 99%

“…17 Considering the high fluorescence intensity and narrow absorption/emission peaks, the integration of boron dipyrromethene (BDP) into frameworks can separate the aggregated BDP molecules, and thus 24-fold enhancement of ECL intensity is obtained due to the suppressed nonradiative energy dissipation. 18 Furthermore, using hydroquinone and phenanthroline as redox couples, an electroactive MOF (E-MOF) with a one-dimensional zigzag chain is designed as an efficient crystalline ECL emitter in an aqueous medium (Figure 2A). The mixed-ligand E-MOF shows consistency in experimental and simulated powder X-ray diffraction (PXRD) (Figure 2B), suggesting its flawless crystal structure.…”

Section: Design With Electroactive Luminophore Ligandsmentioning

confidence: 99%

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Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Luo

Zhu

et al. 2023

Acc. Chem. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Electrochemiluminescence (ECL) is a powerful transduction technique, which depends critically on the formation of the excited emitter through the charge transfer between the electrochemical reaction intermediates of the emitter and the co-reactant/emitter. The exploration of ECL mechanisms for conventional nanoemitters is limited due to the uncontrollable charge transfer process. With the development of molecular nanocrystals, reticular structures such as metal−organic frameworks (MOFs) and covalent organic frameworks (COFs) have been utilized as atomically precise semiconducting materials. The long-range order in crystalline frameworks and the tunable coupling among building blocks promote the quick development of electrically conductive frameworks. Especially, the reticular charge transfer can be regulated by both interlayer electron coupling and intralayer topology-templated conjugation. By modulating intramolecular or intermolecular charge mobility, reticular structures could serve as promising candidates for enhancing ECL. Thus, reticular crystalline nanoemitters with different topologies provide a confined platform to understand ECL fundamentals for designing next-generation ECL devices.Aiming at exploring the mechanism of ECL emission, our group has developed a series of ECL nanoemitters as well as enhancement strategies of ECL emission in the past 20 years. A series of water-soluble ligandcapped quantum dots were introduced as ECL nanoemitters to create sensitive analytical methods for detecting and tracing biomarkers. The functionalized polymer dots were also designed as ECL nanoemitters for imaging of membrane proteins with signal transduction strategies of dual resonance energy transfer and dual intramolecular electron transfer. To decode the ECL fundamental and enhancement mechanisms, an electroactive MOF with accurate molecular structure was first constructed with two redox ligands as a highly crystallized ECL nanoemitter in aqueous medium. Through the mixed-ligand approach, luminophores and co-reactants were integrated into one MOF structure for self-enhanced ECL. Furthermore, several donor−acceptor COFs were developed as efficient ECL nanoemitters with tunable intrareticular charge transfer. The atomically precise structure of conductive frameworks established clear correlations between the structure and charge transport in these materials. Therefore, reticular materials as crystalline ECL nanoemitters have demonstrated both proof of concept and mechanistic innovation.In this Account, taking advantage of reticular materials with accurate molecular structure, we survey the design of the electroactive reticular materials including MOFs and COFs as crystalline ECL nanoemitters at the molecular level. The enhancement mechanisms of ECL emission of various topology frameworks are discussed via the regulation of reticular energy transfer and charge transfer and the accumulation of anion/cation radicals. Our perspective on the reticular ECL nanoemitters is ...

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Section: Structural Design Of Reticular Ecl Nanoemittersmentioning

confidence: 99%

Section: Design With Electroactive Luminophore Ligandsmentioning

confidence: 99%

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Luo

Zhu

et al. 2023

Acc. Chem. Res.

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“…Furthermore, it was found that the individual TP-TBDA and TCNQ cannot respond to UO 2 2+ under the same conditions, manifesting that the assembly of the host−guest system is necessary for monitoring UO 2 2+ (Figure S17). Simultaneously, the presence of UO 2 2+ caused the position of the reduction peak in the CV curve of TP-TBDA@TCNQ to shift toward a more negative voltage, accompanied by the decrease of the peak current (Figure 5b), indicating that the electrode surface charge transfer of the ECL system is hindered, 47 which increases the difficulty of the electrode reaction and affects the emission of ECL.…”

Section: +mentioning

confidence: 99%

Guest Molecular Assembly Strategy in Covalent Organic Frameworks for Electrochemiluminescence Sensing of Uranyl

Jiang,

Li,

et al. 2023

Anal. Chem.

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The application of covalent organic frameworks (COFs) in electrochemiluminescence (ECL) is promising in environmental monitoring. Developing an emerging design strategy to expand the class of COF-based ECL luminophores is highly desirable. Here, a COF-based host−guest system was constructed through guest molecular assembly to deal with nuclear contamination analysis. The efficient charge transport network was formed by inserting an electron-withdrawing guest tetracyanoquinodimethane (TCNQ) into the open space of the COF host (TP-TBDA; TP = 2,4,6-trihydroxy-1,3,5-benzenetricarbaldehyde and TBDA = 2,5-di(thiophen-2-yl)benzene-1,4-diamine) with an electron-donating property; the construction of the COF-based host−guest system (TP-TBDA@TCNQ) triggered the ECL emission of non-emitting TP-TBDA. Furthermore, the dense active sites in TP-TBDA were utilized to capture the target substance UO 2 2+ . The presence of UO 2 2+ broke the charge-transfer effect in TP-TBDA@TCNQ, resulting in the weakening of the ECL signal, thus the established ECL system integrating the low detection limit with high selectivity monitors UO 2 2+ . This COF-based host− guest system provides a novel material platform for constructing late-model ECL luminophores and creates an opportunity for the vigorous ECL technology.

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“…[29,31,32] Recently, the BODIPY molecules as building blocks are used to construct the MOFs and their photo-response property has been demonstrated. [33,34] We envisioned that the introduction of BODIPY into COFs can boost the visible-light absorption ability, endowing the BODIPY-based COFs as photocatalyst for organic transformation under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

“…These photophysical and chemical properties of BODIPY attracted tremendous attentions and they can be widely used in photocatalysis, bioimaging, sensing and luminescent devices [29,31,32] . Recently, the BODIPY molecules as building blocks are used to construct the MOFs and their photo‐response property has been demonstrated [33,34] . We envisioned that the introduction of BODIPY into COFs can boost the visible‐light absorption ability, endowing the BODIPY‐based COFs as photocatalyst for organic transformation under mild conditions.…”

Section: Introductionmentioning

confidence: 99%

A BODIPY‐Based 1D Covalent Organic Framework for Photocatalytic Aerobic Oxidation

Zhao

Xie

Chen

et al. 2023

Chemistry An Asian Journal

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Covalent organic frameworks (COFs) as metal‐free photocatalysts have attracted extensive interest. However, the organic transformations photocatalyzed by COFs under mild conditions remain a challenge. Herein, a boron‐dipyrromethene (BODIPY) based 1D COF, namely JNM‐12, was facilely constructed by Schiff‐base condensation reaction. JNM‐12 exhibited strong visible‐light harvesting abilities and suitable photocatalysis energy potentials, enabling the activation of O2 to superoxide anions (O2⋅−) and singlet oxygen (1O2) under visible light irradiation. Benefiting from these properties, JNM‐12 delivered excellent photocatalytic activity in the O2⋅−‐mediated oxidative coupling of amines and 1O2‐engaged aerobic oxidation of enamines. Our work paves a new way for synthesis of COFs as efficient, economical, and green photocatalysts for organic synthesis.

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BODIPY-based metal–organic frameworks as efficient electrochemiluminescence emitters for telomerase detection

Abstract: A boron dipyrromethene (BODIPY)-based metal-organic framework (MOF) nanoemitter was for the first time designed with enhanced electrochemiluminescence (ECL) intensity due to the suppression of non-radiative dissipation originated from the ordered...

Cited by 8 publications

References 41 publications

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Guest Molecular Assembly Strategy in Covalent Organic Frameworks for Electrochemiluminescence Sensing of Uranyl

A BODIPY‐Based 1D Covalent Organic Framework for Photocatalytic Aerobic Oxidation

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