BODIPY-based fluorescent chemosensor for phosgene detection: confocal imaging of nasal mucosa and lung samples from mouse exposed to phosgene

Bifunctional Fluorescent Probes for the Detection of Mustard Gas and Phosgene

“… − The latter is incorporated into a fluorophore in two forms: (a) sulfur amide − and (b) sulfur ketone. − Phosgene is highly electrophilic, and its two highly reactive acyl chloride groups can easily react with hydroxyl or amino groups to form esters or amides. Taking advantage of the bifunctional and electrophilic properties of phosgene, many fluorescent probes are currently designed with two nucleophilic groups as active sites ( o -diamine, − one amine plus one o -hydroxyl, − and o -dihydroxyl), enabling the differentiated response of phosgene and other acidic chlorides (Table S2).…”