Originating within astronomy as a technical term in the first half of the 18th century, the term "personal equation" spread into a litany of other fields including medicine, where it was used widely and variously from the late 19th century to the middle of the 20th century. We explore the personal equation in the medical literatures of the United States and Britain through a systematic analysis of over 700 articles in four prominent medical journals in conjunction with additional relevant source materials. After tracing the term's dispersion from astronomy into medically allied fields, we examine its striking polysemy while using its rich usage as a lens to examine prevailing tensions within contemporary American and British medicine. Stretching from patient and clinician variability to observer variability and error, the personal equation's various meanings reflect debates about the art and science of medical care that persist into the present day. Perspectives in Biology and Medicine M edicine today, as both art and science, embodies a split personality. The ensuing tension-between individualized consideration, experience, and judgment on the one hand, and standardization, objective evidence, and guidelines on the other-plays out in the simultaneous aspirations of the medical humanities and evidence-based medicine, and in a host of other telling terms and movements. This is not a new tension, however. We turn in this paper to the critical but complex history of the term "personal equation" as both reflective and generative of this tension on both sides of the Atlantic during a formative period in medicine from the mid-19th through the mid-20th centuries. The term was featured in almost every realm of medical practice, entering prominent medical dictionaries, books, journal articles, orations, and conference proceedings. 1 In clinical, laboratory, and research settings, medical authors at various times considered the personal equation to be worthy of consideration, study, admiration, dread, cultivation, and control. The tension it reflected and engendered remains long after the term has been discarded. As we consider the language we mobilize and are influenced by today (including terms like "personalized medicine"), it is instructive to dig down into the complex manner by which terms can be introduced, invoked, and even discarded by an evolving and ever-complex profession. Historians of medicine have largely ignored the "personal equation," while historians of science have principally associated it with the disciplines of astronomy and psychology, leading one observer to claim that the personal equation was rarely used outside of these disciplines (Olesko 2003). In recent years, Jimena Canales (2009) has revised the standard account of the personal equation in the history of science by showing the wide disciplinary breadth of usage of the term (in fields ranging from anthropology to physics and mathematics), opening up the history of the personal equation in a way that has yet to be built upon in the history of ...