BNT162b2 Vaccine Effectiveness in Preventing Asymptomatic Infection with SARS-CoV-2 Virus: A Nationwide Historical Cohort Study

Heymann, Anthony; Zacay, Galia; Shasha, David; Bareket, Ronen; Kadim, Itai; Sikron, Fabienne; Tsamir, Judith; Mossinson, David

doi:10.2139/ssrn.3796868

Cited by 7 publications

(5 citation statements)

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“…Furthermore, these findings are in line with recent studies that show fewer symptomatic and asymptomatic infections among the vaccinated, as assessed by routine laboratory PCR testing [ 5 – 7 , 34 ]. Thus, states with a more vaccinated populace have fewer vectors of transmission, so it is no surprise that they also seem to offer more protection from infection even to its unvaccinated residents.…”

Section: Discussionsupporting

confidence: 90%

Higher vaccination rates predict reduction in SARS-CoV-2 transmission across the United States

2022

Infection

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Purpose The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began proliferating widely throughout the world in late 2019/early 2020, creating a global pandemic and health crisis. Although vaccines became available to the public approximately 1 year after the onset of the pandemic, there still remains much hesitancy surrounding vaccination. One key concern comes from reports of breakthrough infections among the vaccinated that show comparable levels of peak viral load as the unvaccinated, calling into question the ability of vaccines to prevent transmission. Therefore young, healthy individuals who are at low risk of serious complications themselves have little incentive to receive a vaccine that they are not convinced will protect others around them. To address this important concern, this study aimed to evaluate the extent to which vaccination rates are associated with reduced SARS-CoV-2 transmission among the unvaccinated population. Methods An observational study was conducted in the United States of America throughout the months of June through September, 2021. Vaccination rate and incidence of coronavirus disease 2019 (COVID-19) were obtained for each state, along with a number of important control variables. Panel data regression was used to predict incidence among the unvaccinated based on each state’s vaccination rate. Results States with a higher proportion of fully vaccinated individuals reported fewer new cases among the remaining unvaccinated population. Conclusion These data add to accumulating evidence that COVID-19 vaccinations can indeed slow the spread of SARS-CoV-2, and are an important tool in society’s arsenal to put this pandemic behind us.

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Section: Discussionsupporting

confidence: 90%

Higher vaccination rates predict reduction in SARS-CoV-2 transmission across the United States

2022

Infection

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“…Furthermore, these findings are in line with recent studies that show fewer symptomatic and asymptomatic infections among the vaccinated, as assessed by routine laboratory PCR testing (6)(7)(8)43). Thus, it's no surprise that states with a more vaccinated populace seem to offer more protection from infection, even to its unvaccinated residents.…”

Section: Discussionsupporting

confidence: 87%

Higher Vaccination Rate Predicts Reduction in SARS-CoV-2 Transmission across the United States

2021

Preprint

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began proliferating widely throughout the world in late 2019/early 2020, creating a global pandemic and health crisis. Although vaccines became available to the public approximately one year after the onset of the pandemic, there still remains much hesitancy surrounding vaccination even two years into the pandemic. One key concern comes from reports of breakthrough infections among the vaccinated that show comparable levels of peak viral load as the unvaccinated, calling into question the ability of vaccines to slow or prevent transmission. Therefore young, healthy individuals who are at low risk of serious complications themselves have little incentive to receive a vaccine that they are not convinced will protect others around them. To address this important concern, this article analyzes COVID-19 incidence in the United States as a function of each state’s vaccination rate. Results show that states with higher percentages of fully vaccinated individuals report fewer new cases among the remaining unvaccinated population. These data add to accumulating evidence that COVID-19 vaccinations can indeed slow the spread of SARS-CoV-2, and are an important tool in society’s arsenal to put this pandemic behind us.

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“…Seven of 30 studies investigated VE against asymptomatic SARS-CoV-2 infections [11,[19][20][21][22]31,32] (Table 2).…”

Section: Prevention Of Asymptomatic Infectionmentioning

confidence: 99%

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021

et al. 2021

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Evidence on COVID-19 vaccine efficacy/effectiveness (VE) in preventing asymptomatic SARS-CoV-2 infections is needed to guide public health recommendations for vaccinated people. We report interim results of a living systematic review. We identified a total of 30 studies that investigated VE against symptomatic and/or asymptomatic infection. In fully vaccinated individuals, VE against symptomatic and asymptomatic infections was 80–90% in nearly all studies. Fully vaccinated persons are less likely to become infected and contribute to transmission.

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BNT162b2 Vaccine Effectiveness in Preventing Asymptomatic Infection with SARS-CoV-2 Virus: A Nationwide Historical Cohort Study

Cited by 7 publications

References 0 publications

Higher vaccination rates predict reduction in SARS-CoV-2 transmission across the United States

Higher vaccination rates predict reduction in SARS-CoV-2 transmission across the United States

Higher Vaccination Rate Predicts Reduction in SARS-CoV-2 Transmission across the United States

Efficacy and effectiveness of COVID-19 vaccines against SARS-CoV-2 infection: interim results of a living systematic review, 1 January to 14 May 2021

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