BNP or NTproBNP? A clinician's perspective

Steiner, Julia; Guglin, Maya

doi:10.1016/j.ijcard.2007.12.093

Cited by 51 publications

(29 citation statements)

References 108 publications

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“…Более вы-раженная реакция МНП на введение мексидола объяснялась несколькими факторами. С одной стороны, препарат, введенный в раннем ПРП, ока-зывал пролонгированный эффект, который объяс-нялся медленным ответом пептида на различные воздействия [1,23]. С другой стороны, некоторые исследователи считают МНП более продуктивным гормоном, чем ПНП в плане действия на органы-мишени: наличие гипертрофии являлось стимули-рующим для усиления образования и выведения пептида, обладающего антигипертрофическим свойством [4,24].…”

Section: рисunclassified

Mexidol Effect on atrial and brain natriuretic peptides of myocytes of the right atrium of rats in the post-reperfusion period

Bugrova¹

2016

MV-MN

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Центральная научно-исследовательская лабора-тория (зав. лабораторией -профессор И.В. Мухи-на), ГБОУ ВПО «Нижегородская государственная медицинская академия» Минздрава России.Методами иммуноцитохимии, трансмис-сионной электронной микроскопии, световой микроскопии исследовали влияние мексидола на процессы накопления и выделения предсердного и мозгового натрийуретических пептидов кардио-миоцитов крыс в постреперфузионном периоде. Выявлена разная реакция пептидов на введение препарата: увеличение продукции предсердного натрийуретического пептида через 60 мин и от-сутствие эффекта через 60 суток постреперфузи-онного периода. На мозговой натрийуретический пептид мексидол оказывал пролонгированное действие через 60 суток и практически не влиял через 60 мин восстановительного периода.Ключевые слова: предсердный натрийу-ретический пептид, мозговой натрийуретический пептид, постреперфузионный период, мексидол.By using methods of immunocytochemistry, transmission electron microscopy, light microscopy we studied the effect of mexidol on the production of atrial and brain natriuretic peptides in cardiac myocytes in post-reperfusion period in rats. We found different reactions of peptides to the injection of the drug. Synthesis and secretion of atrial natriuretic peptide increased after 60 min while the production of brain natriuretic peptide increased after 60 days post-reperfusion period.

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Section: рисunclassified

Mexidol Effect on atrial and brain natriuretic peptides of myocytes of the right atrium of rats in the post-reperfusion period

Bugrova¹

2016

MV-MN

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“…Although this peptide was called BNP, the primary site of BNP synthesis is ventricular myocardium [35]. A 32 aminoacid active hormone, BMP is released by the cardiac ventricles in response to volume expansion and pressure load [31]. BNP is a natriuretic, diuretic, and vasodilatory hormone; it offsets the effects of fluid overload, which causes stretching of the cardiac wall and triggers its secretion.…”

Section: Plasma Bnp and Other Cardiac Markersmentioning

confidence: 99%

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease

Choi¹,

Kim²,

Hyun³

et al. 2010

Journal of Life Science

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Cardiac troponin-I (cTnI), creatine kinase-MB (CK-MB), and C-reactive protein (CRP) are routine cardiac markers for the diagnosis of cardiovascular disease. Recently, brain natriuretic peptide (BNP) has garnered attention as a marker of heart failure. This study was retrospectively designed to investigate the relationships between preoperative BNP, other cardiac markers levels and perioperative parameters in seventy-four adult patients that underwent off-pump coronary artery bypass grafting (OPCAB) and to assess its usefulness for predicting postoperative outcomes. Preoperative levels of BNP, cTnI, CK-MB, and CRP had significantly positive or negative correlations with echocadiographic parameters. There were significantly positive relationships between BNP, cTnI, CK-MB, and CRP concentration. Postoperative mechanical ventilation time had a positive correlation to preoperative levels of cTnI, CK-MB, and CRP, while ICU-staying period had a positive correlation with BNP, cTnI and CK-MB. These results reveal that a preoperative level of BNP is a good predictor and that its combination with cTnI, CK-MB, and CRP might be useful for diagnosis and comprehensive risk stratification of patients with coronary heart diseases, as well as prognosis of perioperative outcomes in OPCAB patients.

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“…This is caused by both increased secretion as well as decreased renal clearance [12]. NT-proBNP has a longer half-life than BNP and is more stable in vitro [13]. …”

Section: Introductionmentioning

confidence: 99%

Determinants of N-Terminal Pro-Brain Natriuretic Peptide Variation in Hemodialysis Patients and Prediction of Survival

Snaedal¹,

Qureshi

Carrero

et al. 2014

Blood Purif

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Background/Aims: N-Terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of cardiac events and death in the general population and in chronic kidney disease. There is limited information on how natriuretic peptides vary in dialysis patients. The aim of this study was to analyze NT-proBNP variability, factors predicting its variability and survival related to NT-proBNP variability. Methods: A prospective 3-month observational study of prevalent hemodialysis patients with monthly measurements of NT-proBNP was carried out. A total of 211 hemodialysis patients were included, and mortality was recorded during 52 months of follow-up. Results: Inflammation was the strongest predictor of NT-proBNP variability. Patients with constantly high NT-proBNP had an increased risk of death adjusting for age, sex, dialysis vintage and comorbidity but not when also adjusting for nutritional status. Conclusions: Longitudinal changes in NT-proBNP are associated with changes in inflammation, nutritional status, age and comorbidity. Due to strong interactions with predictors of mortality such as nutritional status, we were unable to confirm NT-proBNP as an independent marker for mortality in dialysis patients.

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BNP or NTproBNP? A clinician's perspective

Cited by 51 publications

References 108 publications

Mexidol Effect on atrial and brain natriuretic peptides of myocytes of the right atrium of rats in the post-reperfusion period

Mexidol Effect on atrial and brain natriuretic peptides of myocytes of the right atrium of rats in the post-reperfusion period

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease

Determinants of N-Terminal Pro-Brain Natriuretic Peptide Variation in Hemodialysis Patients and Prediction of Survival

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