BNP and congestive heart failure

Cowie, Martin R.; Méndez, Gustavo

doi:10.1053/pcad.2002.24599

Cited by 178 publications

(140 citation statements)

References 204 publications

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“…BNP is secreted mainly by the ventricles in response to volume expansion and pressure load [1,2]. Therefore, one possible explanation for the surprisingly low BNP levels is the reduced ventricular preload in patients with Fontan circulation together with a limited preload reserve [15,16].…”

Section: Resultsmentioning

confidence: 99%

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B‐type natriuretic peptide levels in patients with functionally univentricular hearts after total cavopulmonary connection

Koch

Zink

Singer

et al. 2008

European J of Heart Fail

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Aims: To assess plasma B-type natriuretic peptide (BNP) levels in patients with univentricular hearts late after volume unloading by total cavopulmonary connection (TCPC). Methods: Plasma BNP was measured by sandwich immunoassay in 67 patients after a modified Fontan procedure. BNP levels were compared with age and sex-specific normal values, clinical and echocardiographic data, and results of exercise testing. Results: BNP had a wide range of 5-290 pg/ml, but was normal in 81% of patients, and median BNP was only 13 pg/ml. There was no difference between males and females, between patients with left or right ventricular morphology, and no correlation was found between BNP and age, post-operative follow-up period, maximum exercise capability, peak oxygen uptake, or blood oxygen saturation. New York Heart Association class I patients had lower BNP than class II patients (p = 0.04). Plasma BNP concentration was positively correlated to the number of specific sequelae (r = 0.59, p b 0.001), and to severity of atrioventricular regurgitation (r = 0.38, p = 0.002). 5/13 patients with elevated BNP died during follow-up. Conclusion: BNP plasma concentration was normal in the majority of patients up to 15 years after TCPC. Elevated and increasing BNP levels were associated with increased morbidity and late mortality.

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Section: Resultsmentioning

confidence: 99%

“…B-type natriuretic peptide (BNP) and the N-terminal fragment of its prohormone (NT-proBNP) are established markers of heart failure [1][2][3]. Both peptides have been shown to be useful in a variety of wide-ranging conditions including congenital heart disease [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

B‐type natriuretic peptide levels in patients with functionally univentricular hearts after total cavopulmonary connection

Koch

Zink

Singer

et al. 2008

European J of Heart Fail

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“…Elevated levels of BNP are usually associated with cardiac dysfunction (Cowie and Mendez, 2002). There is also evidence that human small cell lung cancer cell lines produce BNP (Ohsaki et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines

et al. 2003

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Despite advances in the management of solid tumours, the development of metastases continues to be the most significant problem and cause of death for cancer patients. To define genetic determinants of pulmonary metastases, we have applied oligonucleotide microarrays to established murine models of highly metastatic D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. These models are characterised by primary subcutaneous growth in C57BL/6J mice, a period of minimal residual disease and spontaneous pulmonary metastases. Microarray analysis defined seven genes, namely -arginase, brain natriuretic peptide (BNP), interleukin-1 alpha (IL-1 alpha), plasminogen activator inhibitor-2 (PAI-2), surfactant protein C (SP-C), uteroglobin (UG) and wnt-1-induced secreted protein-1 (WISP-1), which were consistently elevated in pulmonary metastases compared to the primary tumour of both D122 and B16-F10.9 models. Previous studies demonstrated that two of these seven genes, IL-1 alpha and PAI-2, are involved in the metastatic process. The results obtained by the microarrays were confirmed by real-time quantitative PCR, for three chosen genes -PAI-2, WISP-1 and UG. Our approach aimed to identify genes essential for the metastatic process in general and for pulmonary metastases specifically. Further research should address the precise role of these genes in the metastasising process to the lungs and test if they could be used as targets for future therapies.

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“…BNP and its more stable and non-active version N-terminal prohormone BNP (NT-proBNP) are secreted by cardiomyocytes in response to pressure and stretch, which (with active BNP) results in a downstream effect of increased natriuresis, diuresis, and vasodilatation [10][11][12][13]. As stretch-response molecules, BNP biomarkers assess fluid status and perform extremely well is situations of diagnostic dilemmas regarding patients' symptoms of acute dyspnea [14,15].…”

Section: Introductionmentioning

confidence: 99%

Plasma cBIN1 Score (CS) Identifies HFrEF and Can Predict Cardiac Hospitalization in Stable Ambulatory Patients

Xie¹,

Hitzeman²,

Zadikany³

et al. 2018

Preprint

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Objective: We determined, in stable ambulatory heart failure with reduced ejection fraction (HFrEF) subjects and matched controls, the capability of a novel blood based cardiac-specific cBIN1 Score (CS), which assesses the health of cardiac muscle, to identify patients with known heart failure (HF) and to prognosticate future hospitalization.Background: Limited clinical tools are available in assessing cardiac muscle health in stable

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BNP and congestive heart failure

Cited by 178 publications

References 204 publications

B‐type natriuretic peptide levels in patients with functionally univentricular hearts after total cavopulmonary connection

B‐type natriuretic peptide levels in patients with functionally univentricular hearts after total cavopulmonary connection

Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines

Plasma cBIN1 Score (CS) Identifies HFrEF and Can Predict Cardiac Hospitalization in Stable Ambulatory Patients

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