BMY 21502 and piracetam facilitate performance of two-choice win-stay water-escape in normal rats

Means, Larry W.; Comer, T R; Moore, Richard B.

doi:10.1007/bf01244703

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…One is the visible discrimination learning task [7][8][9]34] and the other is the T-maze-type place discrimination task [16][17][18][19][20]. The allocentric place discrimination task, however, differs from above two tasks in some important points.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Evaluation of Spatial Working Memory and Motivation by the Allocentric Place Discrimination Task in the Water Maze in Rats

Kikusui

Tonohiro

Kaneko

1999

The Journal of Veterinary Medical Science

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ABSTRACT. In order to evaluate learning and memory deficits separately from and simultaneously with motivational, motor and sensory impairments in identical animals, we developed the allocentric place discrimination task test using a water maze in rats. For this assessment task, two similar, visible platforms, one was fixed and the other was floating, were simultaneously present in a pool, and the working memory of the allocentric place discrimination task was evaluated. After training, the task accuracy was high about 85% correct and animals were used repeatedly. The accuracy decreased significantly when the pool was surrounded with a black curtain. Muscarinic receptor antagonist scopolamine 0.5 mg/kg selectively impaired the accuracy. Muscle relaxant dantrolene 10 mg/kg selectively decreased swimming speed. Under low motivational condition (warm water), still time increased and swimming speed decreased, but the accuracy was not affected. Similar to warm water, opioid receptor agonist morphine 15 mg/kg increased still time and decreased swimming speed. These results suggest that the allocentric place discrimination task is useful in evaluating spatial working memory ability independently of and concurrently with also visual, motor ability and motivation in identical animals.-KEY WORDS: allocentric spatial cognition, motivation, water maze, working memory.

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Section: Discussionmentioning

confidence: 99%

Simultaneous Evaluation of Spatial Working Memory and Motivation by the Allocentric Place Discrimination Task in the Water Maze in Rats

Kikusui

Tonohiro

Kaneko

1999

The Journal of Veterinary Medical Science

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“…The well-known memory-enhancing capacity of piracetam has been studied in a large number of studies in rodents and humans [13]. There is evidence that piracetam not only enhances long-term memory but also affects immediate working shortterm memory [4,16]. Furthermore, animal experiments [5,24] as well as clinical studies in humans [2,6,23] have shown that piracetam also provides neuroprotective effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of Piracetam on Cognitive Performance in Patients Undergoing Bypass Surgery

Uebelhack

Vohs²,

Zytowski³

et al. 2003

Pharmacopsychiatry

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In this study, the protective effect of piracetam on select aspects of cognitive function in patients undergoing bypass surgery was investigated. Male patients (n = 64) with an indication for a surgical revascularization using artificial extracorporal circuits were randomly assigned in a double-blind fashion to receive a single challenge of 12-g piracetam infusion or placebo (sterile saline) prior to the bypass surgery. A brief battery of neuropsychological tests for verbal and non-verbal short-term memory and attention was administered 1 day before and 3 days after the surgical intervention. There was a significant difference in short-term memory and attention, with the piracetam-treated patients producing a better level of performance 3 days after surgery compared to the placebo group. The overall postoperative cognitive function (z-transformation of all 6 test results) was more significantly (p < 0.001) reduced in the placebo group than in the piracetam group (z = -1.19 +/- 0.72 vs. -0.46 +/- 0.58, respectively). A single challenge of 12-g piracetam infusion prior to surgical intervention might offer a short-term neuroprotective effect for patients undergoing cardiac bypass surgery. Whether this effect persists for a longer period of time requires further investigation.

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“…When preliminary research revealed that mice are incapable of performing a single-test-run version of a water-escape working memory task that we have used many times to test rats (Comer & Means, 1989; Means, Comer, & Moore, 1991; Means & Dent, 1991; Means & Kennard, 1991), we conducted an experiment examining variations of the task that provided the mice with more exposures to the trial-dependent information. Thus, Experiment 1 compared three versions of a working memory water-escape task, and Experiment 2 tested the effects of repeated glucose injections on performance of the version of the task found to be optimal for testing mice.…”

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confidence: 99%

Daily glucose injections facilitate performance of a win-stay water-escape working memory task in mice.

Means¹,

Fernandez²

1992

Behavioral Neuroscience

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In an experiment that compared 3 versions of a working memory task, male C57BL/6 mice given either 3 (n = 7) or 5 (n = 7) opportunities (test runs) per trial to choose the escape choice section of a maze acquired a win-stay (spatial matching-to-sample) water-escape task. Mice given only 1 test run per trial (n = 6) were unable to perform above chance level. In a 2nd experiment, 14 mice from the 1st experiment were tested for performance on the 3-test-run version of the task. Each mouse was tested for 12 consecutive days with each of 4 doses of glucose (0, 50, 100, & 250 mg/kg ip) given 30 min before testing. The two higher doses increased the percentage of correct test run choices on all 3 daily test runs across the 12 days of testing. Daily glucose injections facilitated the use of trial-dependent information.

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BMY 21502 and piracetam facilitate performance of two-choice win-stay water-escape in normal rats

Cited by 13 publications

References 24 publications

Simultaneous Evaluation of Spatial Working Memory and Motivation by the Allocentric Place Discrimination Task in the Water Maze in Rats

Simultaneous Evaluation of Spatial Working Memory and Motivation by the Allocentric Place Discrimination Task in the Water Maze in Rats

Effect of Piracetam on Cognitive Performance in Patients Undergoing Bypass Surgery

Daily glucose injections facilitate performance of a win-stay water-escape working memory task in mice.

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