BMSC–HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression
Jonas Eichberger,
Daniel Froschhammer,
Daniela Schulz
et al.
Abstract:In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone marrow-derived MSCs (BMSCs) and head and neck cancer (HNC) cells. This interaction was found to activate specific markers, notably the osteogenic marker alkaline phosphatase and the oncogene Runx2. These activations corresponded with the release of collagenase enz… Show more
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