BMSC and CoQ10 improve behavioural recovery and histological outcome in rat model of Parkinson's disease

Nezhadi, Akram; Ghazi, Farideh; Rassoli, Homa; Bakhtiari, Mitra; Ataiy, Zohreh; Ahmadi-Soleimani, S. Mohammad; Mehdizadeh, Mehdi

doi:10.1016/j.pathophys.2011.05.004

Cited by 15 publications

(9 citation statements)

References 35 publications

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“…Stress oxidative, protein oxidation, Reactive Oxygen Species (ROS) formation, and subsequent neuronal death are reported following Aβ deposition generated by an imbalance between ROS and internal antioxidants. Evidence show that appropriate nourishing with external antioxidants could improve brain damage and cognitive function ( Khodamoradi, Komaki, Salehi, Shahidi, & Sarihi, 2015 ; Nezhadi et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study

Mehdizadeh

Shojaee

et al. 2017

BCN

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Introduction:The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ)-induced memory impairment.Methods:Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Aβ (1-40) and C. rotundus (400 mg/kg, intraperitoneally). Spatial memory was assessed by the Morris water-maze (MWM) task.Results:In the MWM, Aβ (1-40) significantly increased escape latency and traveled distance (P<0.001). The administration of C. rotundus attenuated the Aβ-induced memory impairment in the MWM task.Conclusion:The current study findings showed that C. Rotundus could improve the learning impairment, following the Aβ treatment, and it may lead to an improvement of AD-induced cognitive dysfunction.

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Section: Introductionmentioning

confidence: 99%

Short Communication: Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study

Mehdizadeh

Shojaee

et al. 2017

BCN

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“…BMSC s are the most promising candidate in the transplantation of a degenerative nervous system without any immunological problems, it also known for trophic factor expression leads to promising result in axonal regeneration, (an increase neuronal property and functional recovery) combined treatment of CoQ 10 and BMSC showed that better recovery in lesion group as compared to individual treatment of CoQ 10 and found increased level of tyrosine hydroxylase gene expression. The study reported that combined treatment can be effective in Parkinson's disease 19 .…”

Section: Review Of Literaturesmentioning

confidence: 98%

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2020

IJPSR

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Coenzyme Q 10 (ubiquinone) is a lipophilic benzoquinone substance. It is a pivotal component to the oxidative phosphorylation in the inner mitochondrial membrane of all aerobic cells as well as diminishes reactive oxygen species (ROS). Exogenous sources for CoQ 10 are grapes seed oil, walnuts, pistachios, spinach, and sesame seed. At present, it is being utilized as an antioxidant agent. Recent studies have revealed its neuroprotective action. In the present review, the comprehensive pharmacological benefits of coenzyme Q 10 on the central nervous system (CNS) has been revealed. Many studies were taken into considerations and compiled in accordance with their activities. Amongst those, the study using in-vitro models referring to neuronal toxicity and animal models of neurodegenerative diseases have been covered. Multiple outcomes have now evolved assisting the role of reactive oxygen species and neuroinflammation in the pathogenesis of the neurodegenerative disorder. The drug coenzyme Q 10 has been administered in a human subject with reference to their age and body weight. In case of increased oxidative stress and few selective cases of gene mutation, the energy production in mitochondria is highly impaired and the deficiency also happens in brain cells which is a leading cause in pathogenesis of premature aging and neurodegenerative diseases. Potential neuroprotective effects of coenzyme Q 10 have also been emphasized in several neurodegenerative disorders such as Parkinson's disease (PD), Huntington's disease and Alzheimer's disease (AD). This article contributes a pervasive review on the utility of coenzyme Q 10 in the management as well as in the prevention of many illnesses as for example, hyperlipidemia, coronary artery disease, myocardial infarction and kidney disease.

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“…Indeed, experimental studies have reported that BMSCs can ameliorate neurologic defi cits and facilitate functional recovery in many disorders of the central nervous system, such as Parkinson's disease [10] , trauma, spinal cord injury, multiple sclerosis, and cerebral ischemia [9] .…”

Section: Biological Characteristics Of Bmscsmentioning

confidence: 99%

Bone marrow stromal cells as a therapeutic treatment for ischemic stroke

Yang

Zhu

et al. 2014

Neurosci. Bull.

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Cerebral ischemia remains the most frequent cause of death and quality-of-life impairments due to neurological deficits, and accounts for the majority of total healthcare costs. However, treatments for cerebral ischemia are limited. Over the last decade, bone marrow stromal cell (BMSC) therapy has emerged as a particularly appealing option, as it is possible to help patients even when initiated days or even weeks after the ischemic insult. BMSCs are a class of multipotent, self-renewing cells that give rise to differentiated progeny when implanted into appropriate tissues. Therapeutic effects of BMSC treatment for ischemic stroke, including sensory and motor recovery, have been reported in pre-clinical studies and clinical trials. In this article, we review the recent progress in BMSC-based therapy for ischemic stroke, focusing on the route of delivery and pre-processing of BMSCs. Selecting an optimal delivery route is of particular importance. The ideal approach, as well as the least risky, for translational applications still requires further identification. Appropriate preprocessing of BMSCs or combination therapy has the benefi t of achieving the maximum possible restoration. Further pre-clinical studies are required to determine the time-window for transplantation and the appropriate dosage of cells.

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BMSC and CoQ10 improve behavioural recovery and histological outcome in rat model of Parkinson's disease

Cited by 15 publications

References 35 publications

Short Communication: Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study

Short Communication: Protective Effects of Cyperus Rotundus Extract on Amyloid β-Peptide (1-40)-Induced Memory Impairment in Male Rats: A Behavioral Study

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Bone marrow stromal cells as a therapeutic treatment for ischemic stroke

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