BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Whittle, Andrew J.; Carobbio, Stefania; Martins, Luís; Slawik, Marc; Hondares, Elayne; Vázquez, María J.; Morgan, Donald A.; Csikasz, Robert I.; Gallego, Rosalı́a; Rodríguez‐Cuenca, Sergio; Dale, Martin; Virtue, Samuel; Villarroya, Francesc; Cannon, Barbara; Rahmouni, Kamal; López, Miguel; Vidal-Puig, António

doi:10.1016/j.cell.2012.02.066

Cited by 488 publications

(557 citation statements)

References 56 publications

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“…Interestingly, Bmp8b is also expressed in certain hypothalamic nuclei. Injection into the brain with Bmp8b increases the sympathetic outflow to BAT but not other tissues and leads to weight loss in mice 141 . Although more studies are needed to assess the effect of Bmp8b on other tissues, Bmp8b is a promising target for therapeutics at this stage.…”

Section: Sympathetic Nerve Control Of Brown and Beige Fatmentioning

confidence: 99%

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Brown and beige fat: development, function and therapeutic potential

Harms

Seale

2013

Nat Med

1,903

2,054

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Adipose tissue, best known for its role in fat storage, can also suppress weight gain and metabolic disease through the action of specialized, heat-producing adipocytes. Brown adipocytes are located in dedicated depots and express constitutively high levels of thermogenic genes, whereas inducible 'brown-like' adipocytes, also known as beige cells, develop in white fat in response to various activators. The activities of brown and beige fat cells reduce metabolic disease, including obesity, in mice and correlate with leanness in humans. Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.npg

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Section: Sympathetic Nerve Control Of Brown and Beige Fatmentioning

confidence: 99%

“…Bmp8b is produced by mature brown fat cells and functions to amplify the thermogenic response of brown adipocytes to adrenergic activators 141 (Fig. 4).…”

Section: Sympathetic Nerve Control Of Brown and Beige Fatmentioning

confidence: 99%

Brown and beige fat: development, function and therapeutic potential

Harms

Seale

2013

Nat Med

1,903

2,054

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“…The master (107)). Among these, secreted factors such as ANP (NPPA), BMP8B, irisin and FGF21 that affect brown adipocyte activation and recruitment seem to be particularly promising for the development of new anti-obesity drugs in the near future (22,122,123,124,125).…”

Section: Human Adipose Organ Plasticity and Therapeutic Prospectsmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

Giordano

Smorlesi

Frontini

et al. 2014

European Journal of Endocrinology

213

177

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In mammals, adipocytes are lipid-laden cells making up the parenchyma of the multi-depot adipose organ. White adipocytes store lipids for release as free fatty acids during fasting periods; brown adipocytes burn glucose and lipids to maintain thermal homeostasis. A third type of adipocyte, the pink adipocyte, has recently been characterised in mouse subcutaneous fat depots during pregnancy and lactation. Pink adipocytes are mammary gland alveolar epithelial cells whose role is to produce and secrete milk. Emerging evidence suggests that they derive from the transdifferentiation of subcutaneous white adipocytes. The functional response of the adipose organ to a range of metabolic and environmental challenges highlights its extraordinary plasticity. Cold exposure induces an increase in the 'brown' component of the organ to meet the increased thermal demand; in states of positive energy balance, the 'white' component expands to store excess nutrients; finally, the 'pink' component develops in subcutaneous depots during pregnancy to ensure litter feeding. At the cell level, plasticity is provided not only by stem cell proliferation and differentiation but also, distinctively, by direct transdifferentiation of fully differentiated adipocytes by the stimuli that induce genetic expression reprogramming and through it a change in phenotype and, consequently function. A greater understanding of adipocyte transdifferentiation mechanisms would have the potential to shed light on their biology as well as inspire novel therapeutic strategies against metabolic syndrome (browning) and breast cancer (pinking).

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“…BMP8B also potentiates the thermogenic response of b-adrenergic stimulation, suggesting that BMP8B is a regulator of thermogenic activity in mature BAT, as opposed to other BMPs, which tend to drive differentiation and cell fate determination. 29 Furthermore, ablation of BMP receptors (BMP receptor type 1A, BMPR1A and activin A receptor type 1, ACVR1) in Myf5 C brown adipocytes results in a marked reduction in BAT mass and compensatory recruitment of brite/beige cells in white fat depots. 17 It remains to be elucidated whether cross talk between TGFb and BMP signaling exists.…”

Section: Bone Morphogenetic Proteinsmentioning

confidence: 99%

Morphogenetics in brown, beige and white fat development

Lin

Farmer

2016

Adipocyte

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Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and b-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat. The discovery of brown and brown-like adipocytes in adult humans has reinvigorated interest in stimulating brown and beige fat development to combat the obesity epidemic. This review focuses on the role that cytoskeleton dynamics play in the regulation of adipocyte biology, specifically beige and brown fat development and how newly discovered adipogenic morphogens affect these processes.

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BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Cited by 488 publications

References 56 publications

Brown and beige fat: development, function and therapeutic potential

Brown and beige fat: development, function and therapeutic potential

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

Morphogenetics in brown, beige and white fat development

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