BMP6 participates in the pathogenesis of adolescent idiopathic scoliosis by regulating osteopenia
Hao Tang,
Jiong Li,
Jia‐Ke Li
et al.
Abstract:Adolescent idiopathic scoliosis (AIS) is a complex disease characterized by three‐dimensional structural deformities of the spine. Its pathogenesis is associated with osteopenia. Bone‐marrow‐derived mesenchymal stem cells (BMSCs) play an important role in bone metabolism. We detected 1919 differentially expressed mRNAs and 744 differentially expressed lncRNAs in BMSCs from seven patients with AIS and five patients without AIS via high‐throughput sequencing. Multiple analyses identified bone morphogenetic prote… Show more
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