BMP2-loaded nanoporous silica nanoparticles promote osteogenic differentiation of human mesenchymal stem cells

Neumann, Anne; Christel, Anne; Kasper, Cornelia; Behrens, Peter

doi:10.1039/c3ra44734k

Cited by 52 publications

(43 citation statements)

References 64 publications

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“…In addition, silica can be easily functionalized, for instance, to modify surface properties and link therapeutic molecules. Indeed, MSNs containing immobilized bone growth factor (BMP-2) on their surface promoted osteogenic differentiation of hMSCs [21]. Zhou et al expanded this approach by in addition to immobilizing BMP-2 on the surface also loading dexamethasone (DEX) into the pores of the particle.…”

Section: Delivery Of Growth Factors Using Nanoparticlesmentioning

confidence: 99%

Enhancing regenerative approaches with nanoparticles

Rijt

Habibović

2017

J. R. Soc. Interface.

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In this review, we discuss recent developments in the field of nanoparticles and their use in tissue regeneration approaches. Owing to their unique chemical properties and flexibility in design, nanoparticles can be used as drug delivery systems, to create novel features within materials or as bioimaging agents, or indeed these properties can be combined to create smart multifunctional structures. This review aims to provide an overview of this research field where the focus will be on nanoparticle-based strategies to stimulate bone regeneration; however, the same principles can be applied for other tissue and organ regeneration strategies. In the first section, nanoparticlebased methods for the delivery of drugs, growth factors and genetic material to promote tissue regeneration are discussed. The second section deals with the addition of nanoparticles to materials to create nanocomposites. Such materials can improve several material properties, including mechanical stability, biocompatibility and biological activity. The third section will deal with the emergence of a relatively new field of research using nanoparticles in advanced cell imaging and stem cell tracking approaches. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.

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Section: Delivery Of Growth Factors Using Nanoparticlesmentioning

confidence: 99%

Enhancing regenerative approaches with nanoparticles

Rijt

Habibović

2017

J. R. Soc. Interface.

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“…The nanoporous silica nanoparticles (NPSNPs) were synthesized according to an adapted literature procedure of Neumann and co-workers [29,39]. They exhibited a spherical morphology and a narrow polydispersity with a mean diameter of 40 nm (Figure 2).…”

Section: Modified Nanoporous Silica Nanoparticlesmentioning

confidence: 99%

“…Nanoporous silica nanoparticles (NPSNPs), in particular, are of great interest to drug delivery, because their size [27][28][29], shape [30][31][32][33][34][35] and surface modification [36][37][38] can be adjusted. NPSNPs can easily be synthesized via the sol-gel route with surfactants as structure-directing agents [39]. These cytotoxic molecules are completely removable by calcination at high temperatures.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

Fullriede¹,

Abendroth²,

Ehlert

et al. 2016

BioNanoMaterials

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Abstract:A pH-sensitive stimulus-response system for controlled drug release was prepared by modifying nano porous silica nanoparticles (NPSNPs) with poly(4-vinylpyridine) using a bismaleimide as linker. At physiological pH values, the polymer serves as gate keeper blocking the pore openings to prevent the release of cargo molecules. At acidic pH values as they can occur during a bacterial infection, the polymer strains become protonated and straighten up due to electrostatic repulsion. The pores are opened and the cargo is released. The drug chlorhexidine was loaded into the pores because of its excellent antibacterial properties and low tendency to form resistances. The release was performed in PBS and diluted hydrochloric acid, respectively. The results showed a considerably higher release in acidic media compared to neutral solvents. Reversibility of this pHdependent release was established. In vitro tests proved good cytocompatibility of the prepared nanoparticles. Antibacterial activity tests with Streptococcus mutans and Staphylococcus aureus revealed promising perspectives of the release system for biofilm prevention. The developed polymer-modified silica nanoparticles can serve as an efficient controlled drug release system for long-term delivery in biomedical applications, such as in treatment of biofilm-associated infections, and could, for example, be used as medical implant coating or as components in dental composite materials.

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“…It has also been reported that increasing the pore diameter of MSNs increases the drug delivery rate. 101 Neumann et al 102 have prepared BMP2-functionalized nanoporous silicon NPs (NPSNPs) using a coupling method via an aminosilane linker. The NPs have an average size ranging from 30 to 50 nm (pore sizẽ 2.8 nm), and the loading efficiency of BMP-2 loaded-NPSNPs was~0.99 μg mg − 1 .…”

Section: Mesoporous Silica Nps As Gf Carriersmentioning

confidence: 99%

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

et al. 2017

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Growth factors (GFs) are soluble proteins secreted by cells that have the ability to regulate a variety of cellular processes and tissue regeneration. However, their translation into clinical applications is limited due to their short effective half-life, low stability, and rapid inactivation by enzymes under physiological conditions. To maximize the effectiveness of GFs and their biologically relevant applicability, a wide variety of sophisticated bio-inspired systems have been developed that augment tissue repair and cellular regeneration by controlling how much, when, and where GFs are released. Recently, protein immobilization techniques combined with nanomaterial carriers have shown promise in mimicking the natural healing cascade during tissue regeneration by augmenting the delivery and effectiveness of GFs. This review evaluates the latest techniques in direct immobilization and relevant biomaterials used for GF loading and release, including synthetic polymers, albumin, polysaccharides, lipids, mesoporous silica-based nanoparticles (NPs), and polymeric capsules. Specifically, we focus on GF-encapsulated NPs in functionalized microporous scaffolds as a promising alternative with the ability to mimic extracellular matrix (ECM) hierarchical architectures and components with high cell affinity and bioactivity. Finally, we discuss how these next-generation, advanced delivery systems have been used to enhance tissue repair and regeneration and consider future implications for their use in the field of regenerative medicine.

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BMP2-loaded nanoporous silica nanoparticles promote osteogenic differentiation of human mesenchymal stem cells

Cited by 52 publications

References 64 publications

Enhancing regenerative approaches with nanoparticles

Enhancing regenerative approaches with nanoparticles

pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

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