BMP2/7 heterodimer is a stronger inducer of bone regeneration in peri-implant bone defects model than BMP2 or BMP7 homodimer

Sun, Ping; Wang, Jingxiao; Zheng, Yuanna; Fan, Yi; Gu, Zhenhua

doi:10.4012/dmj.2011-191

Cited by 47 publications

(53 citation statements)

References 39 publications

(47 reference statements)

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“…On the other hand, proteins such as BMP2 have been shown to enhance bone formation on titanium implants (Schliephake et al 2012;Schliephake et al 2008), and BMP2/7 heterodimers have been found to exert osteogenic effects on implant surfaces (Sun et al 2012). In the periimplantitis bone tissue investigated here, BMP7 was downregulated, and BMP2 was slightly upregulated.…”

Section: Discussionmentioning

confidence: 99%

The Pathology of Bone Tissue during Peri-Implantitis

et al. 2014

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Dental implants are one of the most frequently used treatment options for tooth replacement. Approximately 30% of patients with dental implants develop peri-implantitis, which is an oral inflammatory disease that leads to loss of the supporting tissues, predominately the bone. For the development of future therapeutic strategies, it is essential to understand the molecular pathophysiology of human dental peri-implant infections. Here, we describe the gene and protein expression patterns of peri-implantitis bone tissue compared with healthy peri-implant bone tissue. Furthermore, cells from the osteoblastic lineage derived from peri-implantitis samples were immortalized and characterized. We applied microarray, quantitative reverse transcription polymerase chain reaction, fluorescence-activated cell sorting, and Western blot analyses. The levels of typical bone matrix molecules, including SPP1, BGLAP, and COL9A1, in patients with periimplantitis were reduced, while the inflammation marker interleukin 8 (IL8) was highly expressed. RUNX2, one of the transcription factors of mature osteoblasts, was also decreased in peri-implantitis. Finally, the human telomerase reverse transcriptase immortalized cell line from peri-implantitis exhibited a more fibro-osteoblastic character than did the healthy control.

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Section: Discussionmentioning

confidence: 99%

The Pathology of Bone Tissue during Peri-Implantitis

et al. 2014

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“…For example, BMP4/7 heterodimer induces stronger activity of mesoderm than BMP4 or BMP7 homodimers in Xenopus. Similarly, BMP2/7 heterodimer has higher activity in bone regeneration than BMP2 or BMP7 homodimers in mammals (46). In addition, BMPs bind to various BMP receptors with different affinities.…”

Section: Factors Involved In the Bmpr2-mediated Signaling Cascadementioning

confidence: 99%

Clinical significance linked to functional defects in bone morphogenetic protein type 2 receptor, BMPR2

et al. 2017

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Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth factor-β (TGF-β) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembrane, kinase, and C-terminal cytoplasmic domains. Bone morphogenetic proteins (BMPs) engage the tetrameric complex, composed of BMPR2 and its corresponding type 1 receptors, which initiates SMAD proteins-mediated signal transduction leading to the expression of target genes implicated in the development or differentiation of the embryo, organs and bones. In particular, genetic alterations of BMPR2 gene are associated with several clinical disorders, including representative pulmonary arterial hypertension, cancers, and metabolic diseases, thus demonstrating the physiological importance of BMPR2. In this mini review, we summarize recent findings regarding the molecular basis of BMPR2 functions in BMP signaling, and the versatile roles of BMPR2. In addition, various aspects of experimentally validated pathogenic mutations of BMPR2 and the linked human diseases will also be discussed, which are important in clinical settings for diagnostics and treatment.

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“…In these previous studies, large segmental bone defects in rats were healed by the implantation of BMP‐2 gene‐activated muscle tissue fragments. Other studies have demonstrated that gene‐enhanced bone repair can be improved by use of growth factor combinations and, recently, the use of BMP heterodimers has emerged as a potent strategy to induce osteogenesis more effectively compared to the homodimer BMP‐2 . However, to date, the osteogenic effect of BMP heterodimers on muscle tissue fragments has not yet been examined and it is unknown whether the muscle‐based expedited gene therapy approach could be improved by use of heterodimers.…”

Section: Introductionmentioning

confidence: 99%