BMP1 Promotes Keloid by Inducing Fibroblast Inflammation and Fibrogenesis
Yi Wang,
Yahui Chen,
Jinfeng Wu
et al.
Abstract:Keloid is a typical fibrotic and inflammatory skin disease with unclear mechanisms and few therapeutic targets. In this study, we found that BMP1 was significantly increased in a collagen high‐expressing subtype of fibroblast by reanalyzing a public single‐cell RNA‐sequence data set of keloid. The number of BMP1‐positive fibroblast cells was increased in keloid fibrotic loci. Increased levels of BMP1 were further validated in the skin tissues and fibroblasts from keloid patients. Additionally, a positive corre… Show more
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