2021
DOI: 10.1016/j.celrep.2021.109289
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BMP signaling is enhanced intracellularly by FHL3 controlling WNT-dependent spatiotemporal emergence of the neural crest

Abstract: Highlights d Fhl3 is an intracellular enhancer of BMP signaling during early development d In vivo Fhl3 synergizes with moderate BMP levels and promotes wnt8 activation d Fhl3 controls the dynamics of BMP and Wnt levels triggering neural crest d Reiterated Fhl3 action in mesoderm/ectoderm impacts two steps of the neural crest GRN

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Cited by 8 publications
(11 citation statements)
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“…More recently, BMP responsive elements were identified upstream of the transcriptional start site of wnt8 . The transcriptional activator of the BMP signalling pathway, Smad1, was able to bind these cis -regulatory elements in the presence of a scaffold protein, Fhl3 ( Alkobtawi et al, 2021 ). A further interaction has been reported on the level of the secreted BMP antagonist Gremlin ( Pegge et al, 2020 ), which interacts with heparan sulfate proteoglycans (HSPGs), a family of cell surface macromolecules that regulate Wnt distribution and signalling (reviewed in Routledge and Scholpp, 2019 ).…”
Section: Further Levels Of Wnt/β-catenin Signalling and Nc Inductionmentioning
confidence: 99%
“…More recently, BMP responsive elements were identified upstream of the transcriptional start site of wnt8 . The transcriptional activator of the BMP signalling pathway, Smad1, was able to bind these cis -regulatory elements in the presence of a scaffold protein, Fhl3 ( Alkobtawi et al, 2021 ). A further interaction has been reported on the level of the secreted BMP antagonist Gremlin ( Pegge et al, 2020 ), which interacts with heparan sulfate proteoglycans (HSPGs), a family of cell surface macromolecules that regulate Wnt distribution and signalling (reviewed in Routledge and Scholpp, 2019 ).…”
Section: Further Levels Of Wnt/β-catenin Signalling and Nc Inductionmentioning
confidence: 99%
“…Interestingly, no direct route was found between nne1 and nc (Fig. 7D), or between ne and pc (Fig.7G), retrieving known biological features, such as the partial neuralization needed for NC induction or the close link between placodes and NNE ( 17, 18 ). Because current tools cannot assess multiple branching simultaneously, we applied branching analysis for each potential developmental route in order to define and compare the gene programs underlying NC vs PC fate decisions along each route.…”
Section: Resultsmentioning
confidence: 99%
“…Using deeper re-sequencing of single cell (SC) series from whole X. tropicalis embryos (17), taken at 8 consecutive developmental stages, followed by updated genome annotation and alignment, we have scrutinized 17138 early dorsal ectoderm cells and 6135 neural crest (NC) cells from early gastrulation stage to post-EMT early migration stage. The large cell number of our new dataset permits assessment of the cellular diversity in the NC population during early induction (at late gastrulation stages 12-13 and neural plate stages [13][14], during neural fold elevation (stages [16][17][18], during EMT (neural tube stages [18][19][20] and at the earliest stages of NC cells emigration (tailbud stage 22).…”
Section: General Strategy For Identification Of Neural Crest and Neur...mentioning
confidence: 99%
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