BMP receptor 1b is required for axon guidance and cell survival in the developing retina

Liu, Janice; Wilson, Steven E.; Reh, Thomas A.

doi:10.1016/s0012-1606(02)00115-x

Cited by 93 publications

(90 citation statements)

References 47 publications

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“…It was previously confirmed that BMP7 may promote DNA synthesis in brain cells cultured in vitro and simultaneously promote the dendrite growth of sympathetic neurons cultured in vitro (12). In rats without BMP type I receptors, the expression of netrin, a nerve growth factor that induces axon growth, is inhibited (13). Therefore, the activation of BMP signal transduction plays an important role in cell proliferation and neural regeneration.…”

Section: Discussionmentioning

confidence: 92%

Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury

Zhang

Pei

et al. 2013

Biomedical Reports

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Abstract. Bone morphogenetic protein 7 (BMP7) is a member of the transforming growth factor-β (TGF-β) superfamily and was initially identified as a protein that may induce bone and cartilage growth in the bone matrix. The present study was conducted in order to investigate the effect of BMP7 on the expression of nestin and glial fibrillary acidic protein (GFAP) in the brain tissue of rats after cerebral ischemia-reperfusion injury. A total of 40 adult healthy male Sprague-Dawley rats were used in this study, of which 10 randomly received a sham operation and the remaining 30 were subjected to a 2-h ischemia and 24-h reperfusion by ligation of the left external and internal carotid arteries. Twenty successfully modeled rats were equally randomized into the treatment and control groups. The rats in the treatment group were intervened with 250 µl BMP7 (0.1 mg/kg) via tail vein injection, whereas the rats in the control and sham operation groups were injected with an equal volume of sterile water for injection. Neurological deficits were evaluated by the Bederson's method at 24 h after ischemia-reperfusion and the brain infarct volume was assessed by 2,3,5-triphenyl tetrazolium chloride coloring. The neuronal apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end-labelling (TUNEL) staining and the expression of nestin and GFAP in the three groups was analyzed by immunohistochemistry. Bederson's score (t=4.66, P<0.01) and focus infarction (t=6.98, P<0.01) were lower in the BMP7 treatment group compared to those in the control group. In addition, the number of TUNEL-positive cells in the treatment group was lower compared to that in the control group (P<0.01). Compared to the control group, the expression of nestin and GFAP was enhanced in the BMP7 treatment group (P<0.01). Therefore, BMP7 may upregulate the expression of nestin and GFAP and promote neural regeneration to protect animals against ischemia-reperfusion injury.

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Section: Discussionmentioning

confidence: 92%

Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury

Zhang

Pei

et al. 2013

Biomedical Reports

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“…The same appears to apply to other stress-induced p53 target genes, as revealed by comparative expression analysis in wild-type and p53-deficient mice, demonstrating both p53-dependent and p53-independent expression of Bax, Fas, Killer, and Mdm2 in different cell types of adult mice. 54,55 Perp and its PMP22 relatives: possible mechanisms of action During embryonic development, several important regulators, such as members of the family of Bone Morphogenetic proteins, have both pro-and antiapoptotic effects, depending on the cellular context (see for example Liu et al 56 and Israsena and Kessler 57 ). However, the molecular mechanisms underlying these contrary effects are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Perp is required for tissue-specific cell survival during zebrafish development

2004

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The tumor suppressor p53 has two alternative effects, causing either cell cycle arrest or apoptosis. These different effects are supposed to be mediated by the transcriptional activation of different target genes. perp, encoding a transmembrane protein of the Pmp22 family, is a transcriptional p53 target exclusively upregulated in apoptotic cells. However, its role during normal development had remained largely unclear. Here, we report the isolation and characterization of a zebrafish perp homolog. Upon overexpression in early zebrafish embryos, perp induces apoptosis. In addition, it contributes to p53-dependent and UVinduced cell death. However, during normal zebrafish development, perp displays a p53-independent and spatially restricted expression in specific cell types and tissues. Antisensemediated loss of Perp function leads to increased apoptosis in perp-expressing cells of the developing skin and notochord. We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival. Cell Death and Differentiation (2005) Keywords: perp; p53; pmp22; apoptosis; cell survival; zebrafish; development Abbreviations: AO, acridine orange; BrdU, 5 0 Bromo-2 0 -desoxyuridine; DNp63, amino-terminally truncated isoform of p63; EST, expressed sequence tag; EVL, enveloping layer; hpf, hours postfertilization; mdm2, mouse double minute 2; MO, morpholino oligonucleotide; RT-PCR, polymerase chain reaction after reverse transcription of RNA; SDS-PAGE, sodiumdodecylsulfate polyacrylamide gel electrophoresis; TAp73, transactivating N-terminally full-length isoform of p73; TUNEL, terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling; UV, ultraviolet; 4 mm, four mismatch control

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“…They also regulate the differentiation and survival of retinal neurons (7)(8)(9)(10)(11). Because of the BMP pathway's importance during retina development and in stem cell biology, we wanted to examine its role in inducing and regulating retina regeneration.…”

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confidence: 99%

BMP signaling mediates stem/progenitor cell-induced retina regeneration

Haynes¹,

Gutierrez²,

Aycinena³

et al. 2007

Proceedings of the National Academy of Sciences

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We identified a mechanism whereby retina regeneration in the embryonic chick can be induced by the contribution of stem/ progenitor cells. We show that bone morphogenetic protein (BMP) signaling is sufficient and necessary to induce retina regeneration and that its action can be divided into two phases. By 3 days after postretinectomy (d PR), the BMP pathway directs proliferation and regeneration through the activation of Smad (canonical BMP pathway) and the up-regulation of FGF signaling by the MAPK pathway. By 7d PR, it induces apoptosis by activating p38 (a noncanonical BMP pathway) and down-regulating FGF signaling (by both MAPK and AKT pathways). Apoptosis at this later stage can be prevented, and BMP-induced regeneration can be further induced by inhibition of p38. These results unravel a mechanism for stem/ progenitor cell-mediated retina regeneration, where BMP activation establishes a cross-talk with the FGF pathway and selectively activates the canonical and noncanonical BMP pathways. Retina stem/progenitor cells exist in other species, including humans. Thus, our findings provide insights on how retinal stem cells can be activated for possible regenerative therapies.p38 ͉ FGF B one morphogenetic proteins (BMPs) are secreted signaling proteins that elicit their effect by binding to a heterodimer receptor complex composed of a BMP type I receptor (BMPRIA or BMPRIB) and a BMP type II receptor (BMPRII) (1). The BMP pathway can activate the canonical downstream effector, Smad, or a noncanonical downstream effector, transforming growth factor-␤-activated kinase (TAK1) (1). Several endogenous inhibitors, including noggin, chordin, follistatin, and gremlin, can regulate the ability of BMP to activate these pathways (2).In the developing retina, BMP2, BMP4, and BMP7, as well as the BMP receptors, are expressed in the chick (3) and mouse (4-6) and have been found to play a role in establishing the dorsal/ventral patterning of the retina. They also regulate the differentiation and survival of retinal neurons (7-11). Because of the BMP pathway's importance during retina development and in stem cell biology, we wanted to examine its role in inducing and regulating retina regeneration.A population of retinal stem cells is maintained after retinal development in the anterior margin of the eye in many vertebrates, including humans (12, 13). In most vertebrates, these retinal stem cells remain quiescent and do not respond to injury. However, cells in the anterior margin of the embryonic chick eye respond to injury during a limited time of retina development, providing an opportunity to study the induction process of these stem/progenitor cells (13-15).The embryonic chick has been shown to regenerate a complete retina in Ϸ7 days as long as a retinectomy is performed on or around embryonic day 4 (E4) and a source of FGF is added (14,16,17). In the presence of ectopic FGF2, regeneration takes place by transdifferentiation of the retinal pigmented epithelium (RPE) and the activation of retinal stem/progenitor cells (RS/ R...

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BMP receptor 1b is required for axon guidance and cell survival in the developing retina

Cited by 93 publications

References 47 publications

Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury

Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury

Perp is required for tissue-specific cell survival during zebrafish development

BMP signaling mediates stem/progenitor cell-induced retina regeneration

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