2010
DOI: 10.1083/jcb.200908048
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BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Abstract: Astrocyte differentiation and maintenance is promoted by BMP signaling, which induces REST/NRSF to repress neuronal genes.

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Cited by 82 publications
(83 citation statements)
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“…Despite the fact that the arrested cells were localized to the white matter where glial cells normally reside, and that normally glia and not neurons retain REST (22), these cells unexpectedly differentiated into neurons. This finding is surprising because REST is a repressor of neuronal-trait genes, suggesting that the REST-expressing cells circumvented the presence of REST and initiated neurogenesis, albeit with a delay.…”
Section: Discussionmentioning
confidence: 99%
“…Despite the fact that the arrested cells were localized to the white matter where glial cells normally reside, and that normally glia and not neurons retain REST (22), these cells unexpectedly differentiated into neurons. This finding is surprising because REST is a repressor of neuronal-trait genes, suggesting that the REST-expressing cells circumvented the presence of REST and initiated neurogenesis, albeit with a delay.…”
Section: Discussionmentioning
confidence: 99%
“…37 In addition, REST is modulated by multiple developmental cues, including patterning and specification factors (e.g., RA, BMP and WNT). 38,39 These observations imply that REST acts as a regulator of multiple stages of embryonic and neural development through precise regulation of neural developmental genes.…”
Section: Rest and Corest In Developmental Processesmentioning
confidence: 99%
“…Our observations are consistent with a subsequent study demonstrating that BMP signaling upregulates REST expression which, in turn, promotes astroglial lineage specification and maintenance. 39 We also identified other REST and CoREST target genes responsible for mediating a broad array of biological processes that may be involved in determining glial cell identity and function. These included numerous epigenetic (e.g., Hist1 h4a, Mbd6, Scmh1, Smarca2 and Smc4l1) and cell cycle regulatory (e.g., Ccna2, Ccnd1, Cdc34, Cdk5r1 and Cdkn2c) genes as well as many classes of cell surface identity (e.g., protocadherin, olfactory receptors, vomeronasal receptors and cell adhesion and additional transmembrane proteins) factors.…”
mentioning
confidence: 99%
“…Together, these findings led to the notion that the switch from the self-renewal stage to the neurogenic stage of precursor cells (Figure 1) is dependent upon the downregulation of REST by SCF-ïą-TrCP (Figure 3c). Although REST also plays a role in glia cell differentiation, it is unclear if ubiquitination of REST by SCF-ïą-TrCP is also involved in gliogenesis 68 .…”
Section: Regulation Of Proneural Gene Expression By Ubiquitination-dementioning
confidence: 99%