BMP-2/ACS/Allograft for Combined Maxillary Alveolar Split/Sinus Floor Grafting With and Without Simultaneous Dental Implant Placement: Report of 21 Implants Placed into 7 Alveolar Split Sites Followed for up to 3 Years

This systematic review revealed that the use of rhBMP-2 in maxillary sinus floor augmentation achieved similar clinical and histometric outcomes when compared to conventional sinus grafting procedures after a healing period of 6-9 months. However, previous studies showed the morbidity and other patient-reported outcomes were improved in rhBMP-2 approaches as compared to bone autograft procedures (both intraoral and extraoral bone harvesting because no donor site is required). Long-term studies are required to determine the cost-benefit of sinus floor augmentation procedures for patients requiring implant reconstruction.

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“…; Jensen et al. , , ; Jensen & Adams ; Luiz et al. ) were further excluded; the reasons for exclusion were listed in Table .…”

Section: Resultsmentioning

confidence: 99%

Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and meta‐analysis

Lin

Lim

Chan

et al. 2015

Clinical Oral Implants Res

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“…A retrospective analysis in seven patients receiving 2‐stage sinus augmentation with rhBMP‐2/ACS and an allograft showed successful osseointegration at 3 years of follow‐up and stable aesthetic outcomes (Jensen, Kuhlke, Leopardi, Adams & Ringeman, ).…”

Section: Resultsmentioning

confidence: 99%

The use of bioactive factors to enhance bone regeneration: A narrative review

Donos

Dereka

Calciolari

2019

J Clinic Periodontology

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Aim This review critically appraises the available knowledge on the pre‐clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillofacial area. Materials and Methods The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, pre‐clinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri‐implant defects and sinus augmentation models were considered. Results Amongst different bioactive factors, the highest pre‐clinical and clinical evidence of a positive effect on bone formation is associated with rhBMP‐2 and the lowest with amelogenins. While APCs seem to accelerate clinical healing and reduce postoperative discomfort, there is insufficient and contrasting evidence of a significant effect on hard tissue regeneration for the different clinical applications. Conclusions Although there is increasing evidence that bioactive factors might enhance the bone regeneration process, the great heterogeneity of the available studies and the limited number of RCTs do not allow to draw robust conclusions. Issues that still need to be investigated include the optimal carriers for bioactive agents (direct vs. indirect), the dosage, the timing of administration, as well as the possibility of combining different agents to promote synergistic effects.

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“…The use of rhBMP-2 has been used for augmentation of: clefts 6 , experimental critical-size defects 7 , continuity or mandibular alveolar bone defects 3 and sinuses. 8 the pre-maxilla showed to be significantly augmented ( Fig. 8) with the dimension of 14 mm in height and 10 mm in width.…”

Section: Introductionmentioning

confidence: 95%

Reconstruction Of Severely Atrophic Pre-maxilla Using RhBMP-2 And Titanium Mesh For Dental Implants

Ferreira

Escóssia

Silva

et al. 2015

JDOI

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In order to achieve functional and esthetic oral rehabilitations, dental implants must be placed at an ideal tridimensional position in the alveolar bone. A clinical case is presented of a 49-year-old female with a severely resorbed pre-maxilla. Bone augmentation was conducted using the "tent pole" technique with human recombinant morphogenetic bone protein-2 embedded in an absorbable collagen sponge and deproteinized bovine bone. In addition, a titanium mesh was adapted over the graft to provide support. At 8 months postop, a cone beam computerized tomography (CBCT) scan showed significant bone consolidation. An ideal premaxilla ridge with more than 14 mm of vertical and 10 mm of horizontal width was observed. Four dental implants were placed. Re-entry was 6 months later. Individual crowns were made to substitute the incisors, which were in function for the 1-year follow-up.

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BMP-2/ACS/Allograft for Combined Maxillary Alveolar Split/Sinus Floor Grafting With and Without Simultaneous Dental Implant Placement: Report of 21 Implants Placed into 7 Alveolar Split Sites Followed for up to 3 Years

Cited by 10 publications

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Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and meta‐analysis

Recombinant human bone morphogenetic protein 2 outcomes for maxillary sinus floor augmentation: a systematic review and meta‐analysis

The use of bioactive factors to enhance bone regeneration: A narrative review

Reconstruction Of Severely Atrophic Pre-maxilla Using RhBMP-2 And Titanium Mesh For Dental Implants

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