“…This may lead to increased cholesterol levels in girls as a correlation between total body fat and plasma lipids previously has been shown [30]. Plasma levels of leptin are associated with fat mass and are higher among girls than boys in all age groups [31] and leptin has previously been shown to be associated with increased TC and LDL-C in boys, but not in girls [32].…”
FH girls have higher levels of TC, LDL-C, and non-HDL-C levels than boys from birth up to 19 years of age. This may contribute significantly to the total lifelong cholesterol burden in FH women.
“…This may lead to increased cholesterol levels in girls as a correlation between total body fat and plasma lipids previously has been shown [30]. Plasma levels of leptin are associated with fat mass and are higher among girls than boys in all age groups [31] and leptin has previously been shown to be associated with increased TC and LDL-C in boys, but not in girls [32].…”
FH girls have higher levels of TC, LDL-C, and non-HDL-C levels than boys from birth up to 19 years of age. This may contribute significantly to the total lifelong cholesterol burden in FH women.
“…Furthermore, we suggest that the associations between maternal cholesterol levels and offspring growth might be mediated through various hormones. Cholesterol is required for the production of sex hormones and glucocorticoids [19] and has been positively associated with levels of cortisol [56], leptin [57], and insulin [58], which are highly metabolically active hormones. Initiation of lipid-lowering treatment in non-pregnant subjects has been shown to decrease levels of testosterone [59] and leptin [60] and to decrease insulin secretion [61].…”
Background
Numerous intrauterine factors may affect the offspring’s growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B and apoA1 levels are associated with offspring weight, length, and body mass index from 6 weeks to eight years of age. This has previously been studied to a limited extent.
Methods
This parental negative control study is based on the Norwegian Mother, Father and Child Cohort Study and uses data from the Medical Birth Registry of Norway. We included 713 mothers and fathers with or without self-reported hypercholesterolemia and their offspring. Seven parental metabolites were measured by nuclear magnetic resonance spectroscopy, and offspring weight and length were measured at 12 time points. Data were analyzed by linear spline mixed models, and the results are presented as the interaction between parental metabolite levels and offspring spline (age).
Results
Higher maternal total cholesterol (TC) level was associated with a larger increase in offspring body weight up to 8 years of age (0.03 ≤ Pinteraction ≤ 0.04). Paternal TC level was not associated with change in offspring body weight (0.17 ≤ Pinteraction ≤ 0.25). Higher maternal high-density lipoprotein cholesterol (HDL-C) and apoA1 levels were associated with a lower increase in offspring body weight up to 8 years of age (0.001 ≤ Pinteraction ≤ 0.005). Higher paternal HDL-C and apoA1 levels were associated with a lower increase in offspring body weight up to 5 years of age but a larger increase in offspring body weight from 5 to 8 years of age (0.01 ≤ Pinteraction ≤ 0.03). Parental metabolites were not associated with change in offspring height or body mass index up to 8 years of age (0.07 ≤ Pinteraction ≤ 0.99).
Conclusions
Maternal compared to paternal TC, HDL-C, and apoA1 levels were more strongly and consistently associated with offspring body weight during childhood, supporting a direct intrauterine effect.
“…Among the 16 townships in Taitung, only one has no indigenous people (Green Island Township), and the remaining 15 have indigenous tribes (Taitung County Government 2022). This drew my attention because Taitung is a rural area, and about one-third of the residents are indigenous; they are associated with relatively high levels of physical activity when compared with residents in other urban areas (Wu et al 2016). Since 2015, the Council of Indigenous Peoples in Taiwan provides services that combine indigenous culture with elements from the local environment.…”
Section: Taitung County: Historical-social Context and Its Peoplementioning
Since the first outbreak of COVID-19 in December 2019, numerous countries have experienced waves of outbreaks that have had severe social, economic, and political effects. Many medical and anthropological studies have suggested that tribes and elders in rural and indigenous villages became isolated from the outside world due to a lack of resources and because of cultural constraints. On January 22, 2020, the first confirmed case of COVID-19 in Taiwan was discovered. As of October 23, 2022, 7,476,478 confirmed cases have been reported; of these, only 64,298 were in Taitung County, making it the region with the fewest cases in Taiwan. In this ethnographic study, I visited indigenous tribes in Taiwan that were less affected during the pandemic, conducted in-depth interviews with tribal-care providers, and collected secondary data from reports and social media regarding pandemic prevention on tribes in Taitung County. I also explored the difficulties created by the suspension of tribal-care services due to pandemic-related social distancing and isolation measures, and how care providers overcame these challenges. COVID-19 is not the first and nor will it be the last virus to threaten humans. Thus, it is important to gain insight into how care networks and connections were rebuilt through innovative measures that enabled tribal elders to receive culturally sensitive care and maintain their health during the pandemic.
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