BMI as a Risk Factor for Clinical Outcomes in Patients Hospitalized with COVID‐19 in New York

Abstract

Objective This study examined the association between BMI and clinical outcomes among patients with coronavirus disease 2019 (COVID‐19) infection. Methods A total of 10,861 patients with COVID‐19 infection who were admitted to the Northwell Health system hospitals between March 1, 2020, and April 27, 2020, were included in this study. BMI was classified as underweight, normal weight, overweight, and obesity classes I, II, and III. Primary outcomes were invasive mechanical ventilation (IMV) and death. Results A total of 243 (2.2%) patients were underweight, 2,507 (23.1%) were normal weight, 4,021 (37.0%) had overweight, 2,345 (21.6%) had obesity class I, 990 (9.1%) had obesity class II, and 755 (7.0%) had obesity class III. Patients who had overweight (odds ratio [OR] = 1.27 [95% CI: 1.11‐1.46]), obesity class I (OR = 1.48 [95% CI: 1.27‐1.72]), obesity class II (OR = 1.89 [95% CI: 1.56‐2.28]), and obesity class III (OR = 2.31 [95% CI: 1.88‐2.85]) had an increased risk of requiring IMV. Underweight and obesity classes II and III were statistically associated with death (OR = 1.44 [95% CI: 1.08‐1.92]; OR = 1.25 [95% CI: 1.03‐1.52]; OR = 1.61 [95% CI: 1.30‐2.00], respectively). Among patients who were on IMV, BMI was not associated with inpatient deaths. Conclusions Patients who are underweight or who have obesity are at risk for mechanical ventilation and death, suggesting that pulmonary complications (indicated by IMV) are a significant contributor for poor outcomes in COVID‐19 infection.

Gastrointestinal involvement attenuates COVID-19 severity and mortality

“…To account for potential confounders, especially the age difference, we created a multivariate model where we adjusted for the effect of age, body mass index (BMI), gender, race, diabetes, HTN, chronic lung disease and heart disease on outcomes. Consistent with published literature( 49-52 ) (age and BMI were positively associated with COVID-19 severity and mortality (table S9. Using this multivariate model, we analyzed the impact of GI symptoms on disease outcomes.…”

WITHDRAWN: Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression

“…Meanwhile, Santos et al reported that dyslipidemia as an independent predictor of mortality 19 . Obesity and chronic liver disease, including fatty liver disease, may affect the association between dyslipidemia and poor outcome; because both obesity and fatty liver disease are associated with poor prognosis 24 , 25 , 26 . However, meta-regression analysis was not possible because only three studies were reporting chronic liver disease, and one study reporting obesity.…”

COVID-19 en terapia intensiva: ¿qué pacientes tienen más riesgo de requerir ventilación mecánica?

“…Estas dos características, la edad mayor a 60 años y el sexo masculino, fueron también factores de riesgo asociados con necesidad de VM en nuestra población. Muchos estudios observaron que los pacientes con obesidad (IMC>30 kg/m 2 ) tenían más probabilidades de cursar cuadros graves (15,16). Sin embargo, en nuestra población, si bien más de la mitad de los pacientes eran obesos, esta condición no constituyó un factor independiente predictor de necesidad de VM.…”