BMI and breast cancer in upper Egypt

Amin, Abeer

doi:10.4103/1687-1693.180460

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…Although obesity was associated with a reduced risk of being diagnosed with advanced‐stage breast cancer in the bivariate analysis, when included in the multivariable analysis with other chronic conditions this was no longer significant. This is in keeping with studies from Africa and high‐income countries where obesity did not emerge as being associated with advanced‐stage disease at breast cancer diagnosis. Obesity is a risk factor for luminal type breast cancers, which tend to be slower growing and less likely to be diagnosed at advanced stage .…”

Section: Discussionsupporting

confidence: 89%

The multimorbidity profile of South African women newly diagnosed with breast cancer

Ayeni

Norris

Joffe

et al. 2019

Intl Journal of Cancer

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Multimorbidity in women with breast cancer may delay presentation, affect treatment decisions and outcomes. We described the multimorbidity profile of women with breast cancer, its determinants, associations with stage at diagnosis and treatments received. We collected self-reported data on five chronic conditions (hypertension, diabetes, cerebrovascular diseases, asthma/chronic obstructive pulmonary disease, tuberculosis), determined obesity using body mass index (BMI) and tested HIV status, in women newly diagnosed with breast cancer between January 2016 and April 2018 in five public hospitals in South Africa. We identified determinants of ≥2 of the seven above-mentioned conditions (defined as multimorbidity), multimorbidity itself with stage at diagnosis (advanced [III-IV] vs. early [0-II]) and multimorbidity with treatment modalities received. Among 2,281 women, 1,001 (44%) presented with multimorbidity. Obesity (52.8%), hypertension (41.3%), HIV (22.0%) and diabetes (13.7%) were the chronic conditions that occurred most frequently. Multimorbidity was more common Additional Supporting Information may be found in the online version of this article.with older age (OR = 1.02; 95% CI 1.01-1.03) and higher household socioeconomic status (HSES) (OR = 1.06; 95% CI 1.00-1.13). Multimorbidity was not associated with advanced-stage breast cancer at diagnosis, but for self-reported hypertension there was less likelihood of being diagnosed with advanced-stage disease in the adjusted model (OR 0.80; 95% CI 0.64-0.98). Multimorbidity was associated with first treatment received in those with early-stage disease, p = 0.003. The prevalence of multimorbidity is high among patients with breast cancer. Our findings suggest that multimorbidity had a significant impact on treatment received in those with early-stage disease. There is need to understand the impact of multimorbidity on breast cancer outcomes. What's new?Multimorbidity in women with breast cancer increases with age and may influence treatment decisions and outcome. The authors find that in South Africa 44%, of women newly diagnosed with breast cancer also suffered from other chronic conditions, most prevalently obesity, hypertension, HIV and diabetes. Asian and white women were less likely to present with multimorbidity when compared to black women, but multimorbidity was more common in women with higher socioeconomic status. The authors propose to evaluate the effect of multimorbidity on the South African health system and its impact on scarce health care resources.

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Section: Discussionsupporting

confidence: 89%

The multimorbidity profile of South African women newly diagnosed with breast cancer

Ayeni

Norris

Joffe

et al. 2019

Intl Journal of Cancer

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“…In the present study, the mean age of patients was 49.81 ± 10.75 years and 49.73 ± 10.67 years for groups A and B respectively. This is consistent a study published by Amin (7) in 2016, which revealed that the peak of incidence rates for breast cancer in Egypt lied between 50-60 years old, and their mean age was 50.6 years old.…”

Section: Discussion Discussionsupporting

confidence: 92%

Short Term Outcome of Management of Early Breast Cancer Patients in COVID-19 Era. Ain Shams University Experience

Mohamed¹,

El-Ahmedy²,

Eldeen³

et al. 2023

SGO

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Introduction: COVID-19 implied that a great number of infected individuals were hospitalized and possibly admitted to intensive care units. Cancer centers have rapidly changed models of care by delaying non-urgent surgeries. Breast surgeries were delayed for early breast cancer patients forcing clinicians to potentially alter treatment recommendations by neoadjuvant chemotherapy until appropriate conditions were established. Aim of the work: to assess conservative breast cancer surgery after neo-adjuvant therapy in early breast cancer patients in COVID-19 era as regard surgical outcome, complications and early recurrence comparing results with previous results when patients underwent primary conservative breast surgery. Patients and Methods: This is a cohort study that was conducted 52 patients with early breast cancer stage I and II a. Patients were divided into two groups (A) and (B). Group A included 26 patients who underwent primary conservative breast surgery. Group B included 26 patients who underwent conservative breast surgery after neo-adjuvant therapy during COVID-19 era. Results: Intra-operative re-excision was done in 5 patients (19.2%) in group A and 3 patients (11.5%) in group B. Two patients (7.7%) in group A and 1 patient (3.8%) in group B were converted to modified radical mastectomy. Sentinel lymph node (SLN) was done in all 26 patients in group A while only 25 patients in group B with 1 patient undergoing axillary dissection from the start. SLN was positive in 8 patients (30.8%) in group A & 6 (24 %) patients in group B. Consequently, 8 patients (30.8%) in group A and 7 patients (26.9%) in group B underwent axillary dissection. Conclusion: Conservative breast cancer surgery after neo-adjuvant therapy in early breast cancer patients in COVID-19 era has comparable results to primary conservative breast surgery. Thus, the obligatory decision to delay primary surgery during COVID-19 era by giving neoadjuvant chemotherapy was effective.

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“…Currently, although the demand for cancer care has risen sharply, cancer care services are still limited and therefore, access to such is extremely difficult for many low‐income cancer patients. For example, overweight and obesity were strongly associated with the later stages of breast cancer at diagnosis (stage III, IV) in Egypt, 65 however and perhaps due to lack of screening awareness among women with obesity, breast cancers were discovered quite late and when irreversible. Breast cancer survival for most cases is driven by early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Trends in the burden of most common obesity‐related cancers in 16 Southern Africa development community countries, 1990–2019. Findings from the global burden of disease study

Gona,

Ballout

et al. 2023

Obesity Science & Practice

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BackgroundObesity‐related cancers in the 16 Southern African Development Community (SADC) countries is quite prominent. The changes and time trends of the burden of obesity‐related cancers in developing countries like SADC remain largely unknown. A descriptive epidemiological analysis was conducted to assess the burden of obesity‐related cancers, (liver, esophageal, breast, prostate, colon/rectal, leukemia, ovarian, uterine, pancreatic, kidney, gallbladder/biliary tract, and thyroid cancers) in SADC countries.MethodsData from the 2019 Global Burden of Diseases (GBD) Study was used. Deaths extracted from vital registration, verbal autopsies and ICD codes. Cancer‐type, mortality and prevalence per 100,000 population and 95% uncertainty intervals (UIs) were calculated using the Cause of Death Ensemble model (CODEm) and Spatio‐Temporal Gaussian process with mixed effects regression models. Annual rates of change (AROCs) between 1990 and 2019 and the corresponding UIs were calculated.ResultsThe top age‐standardized mortality rates per 100,000 in 2019 for males were leukemia, 20.1(14.4‐26.4), esophageal cancer, 15.1 (11.2‐19.1), and colon and rectal cancer, 10.3 (8.6‐12.6). For females, breast cancer, 20.6 (16.6‐25.0), leukemia, 17.1 (11.4‐23.7), and esophageal cancer, 8.3(5.5‐10.7), had the leading mortality rates. For males, AROC substantial (p<0.05) increase for kidney cancer for 11 of the countries (AROC from 0.41‐1.24%), colon cancer for eight of the countries (from 0.39‐0.92%), and pancreatic cancer for seven countries (from 0.26‐1.01%). In females, AROC showed substantial increase for pancreatic cancer for 13 of the countries from (0.34‐1.67%), nine countries for kidney cancer (from 0.27‐1.02%), seven countries each for breast cancer (0.35‐1.13%), and ovarian cancer (from 0.33‐1.21%).ConclusionsThere is need for location‐specific and culturally appropriate strategies for better nutrition and weight control, and improved screening for all cancers. Health promotion messaging should target kidney, colon, pancreatic, and breast cancers and encourage clinically tested methods of reducing BMI such as increasing personal physical activity and adoption of effective dietary regimes.This article is protected by copyright. All rights reserved.

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BMI and breast cancer in upper Egypt

Cited by 5 publications

References 10 publications

The multimorbidity profile of South African women newly diagnosed with breast cancer

The multimorbidity profile of South African women newly diagnosed with breast cancer

Short Term Outcome of Management of Early Breast Cancer Patients in COVID-19 Era. Ain Shams University Experience

Trends in the burden of most common obesity‐related cancers in 16 Southern Africa development community countries, 1990–2019. Findings from the global burden of disease study

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