BMAA Neurotoxicity

Metcalf, James S.; Dunlop, Rachael Anne; Cox, Paul Alan; Banack, Sandra Anne

doi:10.1007/978-3-031-15080-7_225

Cited by 1 publication

(1 citation statement)

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“…The glyoxylate and dicarboxylate metabolism metabolic pathways can lead to abnormal levels of various reactants and products in the TCA cycle by affecting the activity of key enzymes of the TCA cycle (Murphy, 2009). L-serine is a nonessential amino acid and a precursor for synthesizing the amino acids glycine and cysteine, and it functions as a phosphorylation site in protein synthesis (Metcalf et al, 2018). L-serine inhibits macrophages and neutrophil-mediated inflammatory responses (He et al, 2019).…”

Section: Glyoxylate and Dicarboxylate Metabolismmentioning

confidence: 99%

Saussurea involucrata oral liquid regulates gut microbiota and serum metabolism during alleviation of collagen‐induced arthritis in rats

Cong

Wang

Meng

et al. 2022

Phytotherapy Research

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Saussurea involucrata oral liquid (SIOL) can clinically relieve symptoms, such as joint pain and swelling, and morning stiffness, in patients with rheumatoid arthritis (RA).However, the mechanism of action remains unclear. This study used a combination of gut microbiota and serum metabolomics analysis to investigate the effects and potential mechanisms of SIOL intervention on rats with RA induced by type II bovine collagen and Freund's complete adjuvant. Results showed that SIOL treatment consequently improved the degree of ankle joint swelling, joint histopathological changes, joint pathological score, and expression of serum-related inflammatory cytokines (interleukin (IL)-1β, IL-4, IL-6, IL-10, and tumor necrosis factor-α) in RA model rats.16 S rRNA sequencing results showed that SIOL increased the relative richness of the Lactobacillus and Bacteroides genus and decreased the relative richness of Romboutsia, Alloprevotella, Blautia, and Helicobacter genus. Serum nontargeted metabolomic results indicated that SIOL could regulate metabolites related to metabolic pathways, such as glycine, serine, threonine, galactose, cysteine, and methionine metabolism. Spearman correlation analysis showed that the regulatory effects of SIOL on the tricarboxylic acid (TCA) cycle, phenylalanine metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, and glyoxylate and dicarboxylate metabolism pathways were correlated with changes in the richness of the Lactobacillus, Romboutsia, Bacteroides, and Alloprevotella genus in the gut microbiome. In conclusion, this study revealed the ameliorative effects of SIOL on RA and suggested that the therapeutic effects of SIOL on RA may be related to the regulation of the community richness of the Lactobacillus, Romboutsia, Bacteroides, and Alloprevotella genus, thereby improving the TCA cycle; phenylalanine metabolism; phenylalanine, tyrosine, and tryptophan biosynthesis, and glyoxylate and dicarboxylate metabolism-related pathways.

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Section: Glyoxylate and Dicarboxylate Metabolismmentioning

confidence: 99%