Blutgruppen und Epidemiologie

Schiff, F.

doi:10.1007/bf01780380

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Enzymes that degrade ABH (0) blood group substances were discovered in human feces over 40 years ago by Schiff and Akune (1). Some of their properties were defined, indicating that they were enzymes (2,3).…”

Section: Introductionmentioning

confidence: 99%

“…Blood group-degrading (BGD)1 enzymes were absent from meconium and appeared in infants' stools after the first few months of life (4). They were also found in small amounts in saliva (1), in achlorhydric gastric juice but not in normal acidic gastric juice (5), and in feces of several other species (6). But their origin, whether from the host or his indiginous microflora, was unsettled.…”

Section: Introductionmentioning

confidence: 99%

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Degradation of blood group antigens in human colon ecosystems. I. In vitro production of ABH blood group-degrading enzymes by enteric bacteria.

Hoskins¹,

Boulding²

1976

J. Clin. Invest.

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A B S T R A C T Human feces contain enzymes producedby enteric bacteria that degrade the A, B, and H blood group antigens of gut mucin glycoproteins. We have studied their production in fecal cultures to determine if such cultures can be a source for enzyme purification and to explore how blood group antigen-degrading enzymes are adapted in individual human colon ecosystems. They were present in fecal cultures from each of 27 healthy subjects, including ABH nonsecretors. Heatsensitive obligate anaerobes are their major source. From 39 to 85% of the total enzyme activity produced by growing cultures was extracellular. Commercial hog gastric mucin and salivary glycoproteins, including Le' saliva which lacks A, B, and H antigens, enhance production of A-, B-, and H-degrading activity in anaerobic fecal cultures irrespective of the glycoprotein's blood group specificity. There is evidence that the host's ABO blood type and secretor status affects the specificity of blood group-degrading enzymes produced by his fecal bacteria in vitro. Thus, fecal inocula from B secretors incubated with hog gastric mucin (A and H specificity) or with Lea saliva produced greater levels of B-degrading than A-or H-degrading activity, and inocula from A secretors in similar media produced greater levels of A-degrading than B-or H-degrading activity. Blood group-degrading enzymes produced in fecal cultures are glycosidases and not proteases. The B-degrading enzyme cleaves the B antigenic determinant a-D-galactose A portion of this work was presented in abstract form in 1972. Clin. Res. 20: 728.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradation of blood group antigens in human colon ecosystems. I. In vitro production of ABH blood group-degrading enzymes by enteric bacteria.

Hoskins¹,

Boulding²

1976

J. Clin. Invest.

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“…INTRODUCTION 37 yr ago Schiff and his coworkers discovered enzymes in human feces and saliva that degraded water-soluble blood group substances (1)(2)(3)(4)(5). The bacterial origin of fecal blood group-degrading (BGD) enzymes was disputed and not established (2,6,7) despite evidence that unidentified oral bacteria produced BGD enzymes in saliva (6,8,9).…”

mentioning

confidence: 99%

Ecological studies of intestinal bacteria. Relation between the specificity of fecal ABO blood group antigen-degrading enzymes from enteric bacteria and the ABO blood group of the human host

Hoskins¹

1969

J. Clin. Invest.

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Untersuchungen über Zusammenhänge zwischen den 4 klassischen Blutgruppen in Verbindung mit den Blutkörpercheneigenschaften M und N und psychopathischer Veranlagung

Hering¹

1939

Z. Ges. Exp. Med.

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Blutgruppen und Epidemiologie

Cited by 5 publications

References 8 publications

Degradation of blood group antigens in human colon ecosystems. I. In vitro production of ABH blood group-degrading enzymes by enteric bacteria.

Degradation of blood group antigens in human colon ecosystems. I. In vitro production of ABH blood group-degrading enzymes by enteric bacteria.

Ecological studies of intestinal bacteria. Relation between the specificity of fecal ABO blood group antigen-degrading enzymes from enteric bacteria and the ABO blood group of the human host

Untersuchungen über Zusammenhänge zwischen den 4 klassischen Blutgruppen in Verbindung mit den Blutkörpercheneigenschaften M und N und psychopathischer Veranlagung

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