Blut- und Gewebespiegel als Parameter für eine quantitative Chemotherapie

Spitzy, K. H.

doi:10.1007/bf01641466

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…A comparison of these values with MIC would appear to indicate that almost all organisms would be sensitive to ccfazolin, whereas almost all would be resis tant to cephalothin. According to Spitzy [53] this is contradictory to therapeutic ex perience.…”

Section: Therapeutic Effectmentioning

confidence: 99%

“…Spitzy [53], Gladtke [17], Palmer [42] and Muckier et al [35] have criticized Naumann's [37] proposal. Naumann claimed that the results of Chisholm et al [13] showed that 4 h after dosing, the levels of antibiotic in the interstitial tissue fluid were equal to blood levels.…”

Section: Therapeutic Effectmentioning

confidence: 99%

“…This statement does not appear to be supported by the data of Chisholm et al Of eight antibiotics tested, only two produced equal levels in tissue and blood 4 h after dosing. Palmer [42], using the data of Chisholm et al [13], has shown that ratios of tissue levels to t/2 values for the antibiotics range from 6 to 0.5 Spitzy [53] provides a further example from the work of Vomel and Hoffmann [59]. Intra venous administration of 4 g of cephalothin t.i.d.…”

Section: Therapeutic Effectmentioning

confidence: 99%

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Pharmacokinetics of Cephalosporin Antibiotics: Protein-Binding Considerations

1978

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The therapeutic activity of antibiotics depends on several factors including absorption, elimination kinetics, distribution in the body, minimal inhibitory concentrations (MIC), stability against enzymes, and plasma-protein binding. Some of these factors are interrelated, for example, the extent of protein binding of an antibiotic influences its elimination kinetics, distribution into tissues, MIC, and antibacterial activity. To evaluate the potential efficacy of an antibiotic, it is important to know the extent of its binding to plasma proteins especially since the protein-bound fraction of the antibiotic is devoid of antibacterial activity. Cephalosporins are a new class of broad-spectrum antibiotics that bind to plasma proteins in different degrees. Reported values for protein binding range from 6% for cephradine to 92% for cefazolin. The effects of protein binding of some of the commonly used cephalosporins on antibacterial activity and several pharmacokinetic parameters are discussed in this communication.

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Section: Therapeutic Effectmentioning

confidence: 99%

Section: Therapeutic Effectmentioning

confidence: 99%

Section: Therapeutic Effectmentioning

confidence: 99%

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Pharmacokinetics of Cephalosporin Antibiotics: Protein-Binding Considerations

1978

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Microbiological basis of antibiotic therapy

Wiedemann¹

1980

Infection

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The parameter used most frequently as a basis for chemotherapy is the minimal inhibitory concentration (MIC). The results of this test are widely influenced by the method applied. A test under in vivo-like conditions is most likely to serve as a basis for rational therapy. The MIC values, measured in different body fluids under varying conditions, also vary, however. Therefore it is unlikely that any measured MIC corresponds with the actual MIC at the site of the infection. The consequence is that a standard test has to be applied which always gives reproducible results. The measured values can thus only to be regarded as relative data in comparison with the concentration of the drug at the site of the infection. Pathogen elimination in vivo during therapy and population-kinetics under the influence of varying concentrations of a drug in vitro are discussed with to the evaluation of the efficacy of different dosages of an antibiotic.

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Kriterien zur Festsetzung von Grenzwerten für die antibakterielle Chemotherapie

Linzenmeier¹

1988

Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Seri

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Blut- und Gewebespiegel als Parameter für eine quantitative Chemotherapie

Cited by 5 publications

References 11 publications

Pharmacokinetics of Cephalosporin Antibiotics: Protein-Binding Considerations

Pharmacokinetics of Cephalosporin Antibiotics: Protein-Binding Considerations

Microbiological basis of antibiotic therapy

Kriterien zur Festsetzung von Grenzwerten für die antibakterielle Chemotherapie

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