Blunted cortisol response to psychosocial stress in atopic patients is associated with decrease in salivary alpha-amylase and aldosterone: Focus on sex and menstrual cycle phase

Allergy and high trait anxiety are related to increases in heart rate variability: results of naturalistic long-term design study

“…Due to similar psychophysiological changes (24) and reported comorbidity of anxiety and allergy (16,17,18,23) as well as the role of stress in allergic process (15), psychological interventions aimed on better coping and reduction of anxiety could be beneficial to allergic patients (45). Similarly, interventions based on normalization of HRV such as HRV biofeedback might also be employed, which has already been demonstrated in a study with asthma (46).…”

“…Another important characteristic of this study is the naturalistic design of data acquisition. Following our previous studies with laboratory design (24), and based on naturalistic studies with salivary cortisol (25) and studies of long term HRV or HRV in time domain parameters, spectral analysis via fast Fourier transform and non-linear analyses of Poincare plot characteristics, and fractal characteristics such as Entropy and Detrended fluctuation analysis (DFA). As indicators of overall HR variability, we used SDNN (standard deviation of all R-R intervals) from time-domain analysis, Total power from spectral analysis, and SD2 (standard deviation of long term RR interval variability) from Poincaré plot.…”

“…These findings were interpreted in context of allostatic model, as inability to react with adaptive stress reaction. While allergy is often associated with increases in anxiety, depression and problems in emotional regulation (17,18), effects of blunted cortisol (41) as well as salivary alpha amylase, which is commonly associated with sympathetic activity (42) and aldosterone (24) were reported for both allergy as well as high trait anxiety. Based on the mentioned effects we could speculate whether choosing only very high trait anxious subjects (STAI-T score < 49) and contrarily very low anxious subjects as controls (STAI-T < 39) could play a role in the observed effects.…”

“…vol 50, n 1, [19][20][21][22][23][24][25][26][27]2018 natural conditions (19,26), we investigated HRV indices and subjective experience of research subjects in relation to stressors during their daily lives. A design with repeated measurements of HRV and subjective self-assessment of experienced stress during longer time period was applied here.…”

Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

“…investigated the endocrine-related effects of PFOA and PFOS using in vitro estrogen receptor (ER) and androgen receptor (AR) transactivation assays and steroidogenesis assay 31 , and the results showed that the gene expression of cyp11b2 related to corticoid biosynthesis was significantly increased by only PFOS. It is known that CYP11B2 is an enzyme involved in the biosynthesis of aldosterone, which play a key role in the development of atopy diseases including asthma 32 . However, as the agonists for peroxisome proliferator-activated receptors (PPARs) signaling pathway 33 , Takacs and Abbott conducted a study to characterize the differential activation of mouse and human PPAR-α, PPAR-β, and PPAR-γ, and the results indicated that PFOA had more trans-activity than PFOS with both the mouse and human PPAR isoforms 34 .…”