Blunted brain activation in patients with schizophrenia in response to emotional cognitive inhibition: A functional near-infrared spectroscopy study

Egashira, Kazuteru; Matsuo, Koji; Nakashima, Mami; Watanuki, Toshio; Harada, Kazuaki; Nakano, Masayuki; Matsubara, Takehiro; Takahashi, Kanji; Watanabe, Yoshifumi

doi:10.1016/j.schres.2014.12.038

Cited by 24 publications

(23 citation statements)

References 58 publications

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“…[3,83] A recent functional near-infrared spectroscopy study showed that the fronto-temporal dysfunction is involved in the pathophysiology of abnormal emotional processing and cognitive inhibition in SZ patients. [84] We also found significant increases in RGMV and RWMV in the right PCUN, which is linked to self-awareness, mentalizing, and the theory of mind. [85,86] Reduced structural and functional connectivity among the amygdala, PCUN, and parietal regions might contribute to abnormalities in emotional processing in SZ patients.…”

Section: Discussionmentioning

confidence: 71%

Discriminative analysis of schizophrenia using support vector machine and recursive feature elimination on structural MRI images

Lu¹,

Yang²,

Wu³

et al. 2016

Medicine

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Section: Discussionmentioning

confidence: 71%

Discriminative analysis of schizophrenia using support vector machine and recursive feature elimination on structural MRI images

Lu¹,

Yang²,

Wu³

et al. 2016

Medicine

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“…Prior fNIRS studies of ASD showed that patients with ASD had blunted activation of the frontopolar prefrontal area during executive tasks (verbal fluency tasks) compared to healthy subjects 16 – 18 . Similarly, several fNIRS studies of SCZ have consistently shown that patients with SCZ have poor activation of the frontotemporal area during executive tasks 19 – 21 and emotional social cognitive tasks 22 , 23 , compared to healthy subjects. However, a comparative study of patients with ASD and SCZ evaluating social cognition and non-social cognition (e.g., executive function) using fNIRS has not been published.…”

Section: Introductionmentioning

confidence: 81%

“…The fNIRS method is noninvasive, relatively insensitive to motion artefacts, and can measure brain function with participants seated in a natural position, with little stress of body restriction during the examination, unlike fMRI which may be stressful to participants. These advantages make fNIRS suitable to assess brain function in subjects with psychiatric disorders such as ASD 16 – 18 and schizophrenia 19 – 23 . Prior fNIRS studies of ASD showed that patients with ASD had blunted activation of the frontopolar prefrontal area during executive tasks (verbal fluency tasks) compared to healthy subjects 16 – 18 .…”

Section: Introductionmentioning

confidence: 99%

Differences in frontotemporal dysfunction during social and non-social cognition tasks between patients with autism spectrum disorder and schizophrenia

Hirata

Egashira²,

Harada

et al. 2018

Sci Rep

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Although literature evidence suggests deficits in social and non-social cognition in patients with autistic spectrum disorder (ASD) and schizophrenia (SCZ), the difference in neural correlates of the impairments between the two disorders has not been elucidated. We examined brain function in response to a non-social cognition and a social cognition task using functional near-infrared spectroscopy (fNIRS) in 13 patients with ASD, 15 patients with SCZ, and 18 healthy subjects. We assessed the brain function of participants using a verbal fluency task and an emotional facial recognition task. The patients with ASD showed significantly reduced brain activation in the left frontotemporal area during both tasks compared to healthy subjects. The patients with ASD with larger score in ‘attention to detail’ in the autism spectrum quotient showed lower activation of the left frontotemporal area during the two tasks. The patients with SCZ showed significantly reduced activation, compared to healthy subjects, and greater activation, compared to patients with ASD, in the area during the verbal fluency task. The patients with SCZ with more severe symptoms had lower brain activation during the task in this area. Our results suggest that two distinct areas are involved in the distinctive brain pathophysiology relevant to cognitive processing in patients with ASD and SCZ.

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“…This response has to be withheld, however, when a no‐go stimulus is presented instead of the go stimulus. There is evidence of increased commission errors in schizophrenia patients, relatives, and people with high schizotypy in some but not all studies (Egashira et al ., ; Groom et al ., ; Simmonite et al ., ; Zou et al ., ).…”

Section: Methodsmentioning

confidence: 99%

Response inhibition and interference control: Effects of schizophrenia, genetic risk, and schizotypy

Ettinger

Aichert²,

Wöstmann³

et al. 2017

Journal of Neuropsychology

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The ability to inhibit inappropriate responses and suppress irrelevant information is a core feature of executive control. In this study, we provide a detailed analysis of prepotent response inhibition and interference in patients with schizophrenia. To further test the role of genetic factors and subclinical schizophrenia-like traits, we additionally studied clinically unaffected, first-degree relatives of schizophrenia patients and assessed dimensions of schizotypy in both relatives and healthy controls. Inhibition and interference control were assessed using a battery comprising the antisaccade, Stroop, stop signal, go/no-go, flanker, and Simon tasks. Schizophrenia patients differed from both relatives and controls in making more errors on the antisaccade task and having longer response times on the Stroop task, especially the incongruent condition. Patients also had general, that is, condition independent, increases in reaction times on the go/no-go and flanker tasks and made more errors on the flanker and Simon tasks, suggesting general performance impairments independent of inhibitory demand. Relatives were characterized by hypometric antisaccade amplitude gain despite normal prosaccades, suggesting a selective deficit in non-standard sensorimotor transformations. Schizotypy was correlated with inhibitory performance across a number of tasks in both relatives and controls. Generally, these effects were independent of verbal intelligence levels. Overall, the findings point to rather selective impairments of inhibitory control in the schizophrenia spectrum and confirm a previously observed deficit in antisaccade spatial accuracy as an endophenotype of schizophrenia.

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Blunted brain activation in patients with schizophrenia in response to emotional cognitive inhibition: A functional near-infrared spectroscopy study

Cited by 24 publications

References 58 publications

Discriminative analysis of schizophrenia using support vector machine and recursive feature elimination on structural MRI images

Discriminative analysis of schizophrenia using support vector machine and recursive feature elimination on structural MRI images

Differences in frontotemporal dysfunction during social and non-social cognition tasks between patients with autism spectrum disorder and schizophrenia

Response inhibition and interference control: Effects of schizophrenia, genetic risk, and schizotypy

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