Blumea balsamifera—A Phytochemical and Pharmacological Review

Abstract

Abstract:The main components of sambong (Blumea balsamifera) are listed in this article. The whole plant and its crude extracts, as well as its isolated constituents, display numerous biological activities, such as antitumor, hepatoprotective, superoxide radical scavenging, antioxidant, antimicrobial and anti-inflammation, anti-plasmodial, anti-tyrosinase, platelet aggregation, enhancing percutaneous penetration, wound healing, anti-obesity, along with disease and insect resistant activities. Although many experimental and biological studies have been carried out, some traditional uses such as rheumatism healing still need to be verified by scientific pharmacological studies, and further studies including phytochemical standardization and bioactivity authentication would be beneficial.

Phylogenetic reconstruction and divergence time estimation of Blumea DC. (Asteraceae: Inuleae) in China based on nrDNA ITS and cpDNA trnL-F sequences

“…Compare with habit, distribution, chromosome number, chemical composition and etc., we found the two main clades differ in habit, ecology, distribution, chromosome number and chemical composition, the Blumea DC. clade contains mostly perennial shrubs or subshrubs, and mostly distributed from evergreen forests, and also with the same chromosome number (2n = 18)and chromosome structure (6M+8m+4sm) (Lu, 1996), also the chemical composition are similar (Pang, Wang, Fan, Chen, Yu, Hu, Wang & Yuan, 2014). And clade II, which is a widespread paleotropical group that comprises mostly annual, weedy herbs of open forests and fields.…”

Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation

“…The half maximal inhibitory concentration (IC50) of HGK for A549 cells was about 22 µM ( Figure 1B), while the IC50s of genkwanin and 3-methoxy genkwanin against A549 cells were >100 µM. A search of the literature has revealed that HGK that was isolated from the leaves of Blumea balsamifera DC displayed strong cytotoxicity against human lung cancer cells (NCI-H187) and a moderate toxicity against oral cavity cancer cells lines (KB) [19]. HGK induced DNA damage, cell cycle arrest, and cell apoptosis in glioma [20].…”

“…Molecules 2019, 24, x FOR PEER REVIEW 3 of 12 leaves of Blumea balsamifera DC displayed strong cytotoxicity against human lung cancer cells (NCI-H187) and a moderate toxicity against oral cavity cancer cells lines (KB) [19]. HGK induced DNA damage, cell cycle arrest, and cell apoptosis in glioma [20].…”

Simultaneous Quantitative Determination of Polyphenolic Compounds in Blumea balsamifera (Ai-Na-Xiang, Sembung) by High-Performance Liquid Chromatography with Photodiode Array Detector

“…In China, it is called as Ai-Na-Xiang, whereas in Philippines it is called Sembung. B. balsamifera showed lots of biological effects on stomach, respiratory system [1], nervous system [2], and also showed sudorific [3], antifungal [4], anticancer [5,6], and antiobesity [4] effects.…”