Bluetongue Virus

Howell, Peter; Verwoerd, Daniel Wynand

doi:10.1007/978-3-7091-3987-5_2

Cited by 51 publications

(30 citation statements)

References 29 publications

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“…In tests in whieh the temperature was carefully controlled all of the orbiviruses except Wallal virus were unaffected by treatment with ether. The results are consistent with those obtained using bluetongue virus (Howell and Verwoerd, 1971) and horsesiekness virus (Howell, 1962). The result with Wallal virus was exceptional, but reprodueible and similar effects of ether on members of the Kemerovo group of orbiviruses have been reported (Borden et al, 1971).…”

Section: Double-stranded Rna Of Orbivirusessupporting

confidence: 90%

SUSCEPTIBILITY OF ORBIVIRUSES TO LOW pH AND TO ORGANIC SOLVENTS

Gorman

1978

Aust J Exp Biol Med

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Summary Six orbiviruses, Corriparta, Wallal, Eubenangee, D'Aguilar, Warrego and Mitchell River, were inactivated within 30 min in solutions of pH less than 6. All but Wallal virus resisted treatment with ether at 1° for 22 h but only Corriparta virus resisted treatment with chloroform at 1° for 22 h. The genomes of the orbiviruses, including Corriparta virus, after electrophoresis in acrylamide gels separated into basically similar patterns which ware distinct from the pattern of reovirus RNA.

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Section: Double-stranded Rna Of Orbivirusessupporting

confidence: 90%

SUSCEPTIBILITY OF ORBIVIRUSES TO LOW pH AND TO ORGANIC SOLVENTS

Gorman

1978

Aust J Exp Biol Med

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“…Aedes mosquitoes are not t h o u g h t to be vectors of B T V although NnISC~VLT et al (13) BTV grown in vertebrate tissue culture does not always produce significant elinieals symptoms when inoculated into sheep. This response varies with the breed of sheep used (6,14). It may also depend on environmental factors such as exposure of animals to sunlight and to stress (15).…”

Section: Discussionmentioning

confidence: 98%

The susceptibility of cell lines ofAedes aegypti (Linn.),Aedes albopictus (Skuse) andAedes pseudoscutellaris (Theobald) to infection with Bluetongue virus

Jennings

Boorman

1979

Archives of Virology

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Bluetongue virus multiplied in cell lines derived from Aedes albopictus and Aedes pseudoscutellaris cells. Virus reached a maximum titre in the Ae. pseudoscutellaris cells three days post inoculation, and in Ae. albopictus cells six days p.i. Virus growth was demonstrated in both cell lines at 27 degrees C and 37 degrees C. Significant titres of virus were still present in the Ae. albopictus cells after five subcultures at 27 degrees C over a period of six weeks. No cytopathic effect was observed in either cell line. A third cell line derived from the mosquito Ae. aegypti did not support the growth of Bluetongue virus.

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“…BTV the prototype member of the genus Orbivirus, family Reoviridae is a non-enveloped, icosahedral, double stranded RNA virus having ten segments in the genome that encode seven structural (VP1 to VP7) and four non-structural proteins (NS1, NS2, NS3 NS3a) [3], [4], [5]. Recently, two more non-structural proteins (NS4 and NS5) have been reported [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis reveals common differential and global gene expression profiles in bluetongue virus serotype 16 (BTV-16) infected peripheral blood mononuclear cells (PBMCs) in sheep and goats

et al. 2017

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Bluetongue is an economically important infectious, arthropod borne viral disease of domestic and wild ruminants, caused by Bluetongue virus (BTV). Sheep are considered the most susceptible hosts, while cattle, buffalo and goats serve as reservoirs. The viral pathogenesis of BTV resulting in presence or absence of clinical disease among different hosts is not clearly understood. In the present study, transcriptome of sheep and goats peripheral blood mononuclear cells infected with BTV-16 was explored. The differentially expressed genes (DEGs) identified were found to be significantly enriched for immune system processes - NFκB signaling, MAPK signaling, Ras signaling, NOD signaling, RIG signaling, TNF signaling, TLR signaling, JAK-STAT signaling and VEGF signaling pathways. Greater numbers of DEGs were found to be involved in immune system processes in goats than in sheep. Interestingly, the DEHC (differentially expressed highly connected) gene network was found to be dense in goats than in sheep. Majority of the DEHC genes in the network were upregulated in goats but down-regulated in sheep. The network of differentially expressed immune genes with the other genes further confirmed these findings. Interferon stimulated genes - IFIT1 (ISG56), IFIT2 (ISG54) and IFIT3 (ISG60) responsible for antiviral state in the host were found to be upregulated in both the species. STAT2 was the TF commonly identified to co-regulate the DEGs, with its network showing genes that are downregulated in sheep but upregulated in goats. The genes dysregulated and the networks perturbed in the present study indicate host variability with a positive shift in immune response to BTV in goats than in sheep.

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Bluetongue Virus

Cited by 51 publications

References 29 publications

SUSCEPTIBILITY OF ORBIVIRUSES TO LOW pH AND TO ORGANIC SOLVENTS

SUSCEPTIBILITY OF ORBIVIRUSES TO LOW pH AND TO ORGANIC SOLVENTS

The susceptibility of cell lines ofAedes aegypti (Linn.),Aedes albopictus (Skuse) andAedes pseudoscutellaris (Theobald) to infection with Bluetongue virus

Transcriptome analysis reveals common differential and global gene expression profiles in bluetongue virus serotype 16 (BTV-16) infected peripheral blood mononuclear cells (PBMCs) in sheep and goats

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