Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

Joseph, James A.; Arendash, Gary W.; Gordon, Marcia N.; Diamond, David M.; Shukitt‐Hale, Barbara; Morgan, Dave; Denisova, Natalia A.

doi:10.1080/1028415031000111282

Cited by 320 publications

(233 citation statements)

References 54 publications

Supporting

Mentioning

221

Contrasting

Unclassified

Order By: Relevance

“…The amount of corn in the control diet was adjusted to compensate for the added volume of the coffee powder or caffeine. The control NIH-31 diet was the same as that used in earlier studies in which other foods were found to be beneficial for mitigating brain aging (Youdim et al 2000;Joseph et al 2003;Casadesus et al 2004;Goyarzu et al 2004;Shukitt-Hale et al 2005). The coffee powder, supplied by Kraft Foods Global, Inc. (Northfield, IL, USA), was prepared by lyophilizing brewed coffee.…”

Section: Dietsmentioning

confidence: 99%

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Shukitt‐Hale

Miller

Chu

et al. 2013

AGE

View full text Add to dashboard Cite

The complex mixture of phytochemicals in fruits and vegetables provides protective health benefits, mainly through additive and/or synergistic effects. The presence of several bioactive compounds, such as polyphenols and caffeine, implicates coffee as a potential nutritional therapeutic in aging. Moderate (three to five cups a day) coffee consumption in humans is associated with a significant decrease in the risk of developing certain chronic diseases. However, the ability of coffee supplementation to improve cognitive function in aged individuals and the effect of the individual components in coffee, such as caffeine, have not been fully evaluated. We fed aged rats (19 months) one of five coffeesupplemented diets (0, 0.165, 0.275, 0.55, and 0.825 % of the diet) for 8 weeks prior to motor and cognitive behavior assessment. Aged rats supplemented with a 0.55 % coffee diet, equivalent to ten cups of coffee, performed better in psychomotor testing (rotarod) and in a working memory task (Morris water maze) compared to aged rats fed a control diet. A diet with 0.55 % coffee appeared to be optimal. The 0.165 % coffeesupplemented group (three cups) showed some improvement in reference memory performance in the Morris water maze. In a subsequent study, the effects of caffeine alone did not account for the performance improvements, showing that the neuroprotective benefits of coffee are not due to caffeine alone, but rather to other bioactive compounds in coffee. Therefore, coffee, in achievable amounts, may reduce both motor and cognitive deficits in aging.

show abstract

Section: Dietsmentioning

confidence: 99%

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Shukitt‐Hale

Miller

Chu

et al. 2013

AGE

View full text Add to dashboard Cite

show abstract

“…The blueberry was then added to the control diet in place of cornstarch, yielding a chow consisting of control diet plus blueberry at 2% (g per kg diet). The diets used in this study are isocaloric and have been used previously (Joseph et al, 1999(Joseph et al, , 2003Willis et al, 2005); for additional information regarding dietary formulations see Joseph et al, 1999). The transplant recipients were maintained on the respective diets for the duration of the study.…”

Section: Subjectsmentioning

confidence: 99%

Dietary Blueberry Supplementation Affects Growth but Not Vascularization of Neural Transplants

Willis

Small

Bickford

et al. 2008

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Transplantation of neural tissue has been attempted as a treatment method for neurodegenerative disorders. Grafted neurons survive to a lesser extent into middle-aged or aged hosts, and survival rates of < 10% of grafted neurons is common. Antioxidant diets, such as blueberry, can exert powerful effects on developing neurons and blood vessels in vitro, but studies are lacking that examine the effects of these diets on transplanted tissues. In this study, we examined the effects of a blueberry diet on survival, growth, and vascularization of fetal hippocampal tissue to the anterior chamber of the eye of young or middle-aged female rats. Previous work from our group showed significant increase in neuronal survival and development with blueberry diet in grafts. However, the effects of antioxidant diet on vascular development in grafts have not been explored previously. The age of the host affected individual vessel morphology in that aged hosts contained grafts with thick, undeveloped walls, and wider lumen. The blood-brain barrier also appeared to be affected by the age of the host. The blueberry diet did not affect vessel morphology or density of vessel-associated protein markers but gave rise to significantly increased growth capacity, cytoarchitecture, and the final size of hippocampal grafts.

show abstract

“…These models are characterised by enhanced indices of oxidative stress and inflammation along with disruption of the dopaminergic system, similar to that observed in healthy, aged animals (187) . Furthermore, a blueberry-rich diet was also shown to be protective in AD models (amyloid precursor protein/PS1 transgenic mice), preventing spatial memory deficits along with enhancement of memory-associated neuronal signalling (180) . In particular, blueberry-supplemented amyloid precursor protein/PS1 mice exhibited greater levels of hippocampal ERK activation as well as hippocampal PKCa activation, both known to be involved in regulation of synaptic plasticity and consolidation of learning and memory (180) .…”

Section: Blueberry and Other Berriesmentioning

confidence: 99%

“…There have been many studies reporting the potential effects of berry supplementation on spatial memory in aged animals (27,(180)(181)(182)(183) . Early studies indicated that long-term supplementation (from 6 to 15 months of age) with berries (blueberry or strawberry) retards age-related decrements in cognitive and neuronal function (181) .…”

Section: Blueberry and Other Berriesmentioning

confidence: 99%

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro

Guerreiro

et al. 2012

Proc. Nutr. Soc.

View full text Add to dashboard Cite

There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs. Flavonoids: Memory: Learning: HippocampusDiet is an important lifestyle factor, which in recent times has been investigated for its influence on cognitive function and the incidence and onset of neurodegenerative disorders (1,2) . It has long been known that a diet high in saturated fats negatively impacts on cognitive processing and increases the risk of neurological dysfunction in both animals and human subjects (3,4) , while energy restriction (reduction in approximately 30 % energy intake) protects the brain from injury (5,6) . Recently, significant evidence has emerged to indicate that phytochemical-rich foods, and in particular those rich in flavonoids, may reverse agerelated deficits in cognitive function in both animals and human subjects (7)(8)(9) . For example, the PAQUID prospective study examined cognitive performance in 1640 subjects (aged at least 65 years and cognitively normal at baseline) on four occasions over a 10-year-period and found that flavonoid-intake was associated with a significantly better cognitive performance over time (7) (P = 0 . 046). Furthermore, a cross-sectional study examining the relationship between the intake of three common flavonoid-containing foods (chocolate, wine and tea) and cognitive performance in elderly individuals revealed that there was a dose-dependent, positive relationship between the intake of these foods and performance on multiple cognitive outcomes (Kendrick Object Learning Test, Digit Symbol Test, Block Design, Mini-Mental State Examination and Controlled Oral Word Association Test) (10) . More recently, the consumption of dietary flavonoids, especially

show abstract

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

Cited by 320 publications

References 54 publications

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Dietary Blueberry Supplementation Affects Growth but Not Vascularization of Neural Transplants

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Contact Info

Product

Resources

About