Blueberry muffin rash at birth due to congenital rubella syndrome

Blueberry muffin baby with cytomegalovirus hepatitis

“…The differential diagnosis of blueberry muffin baby includes conditions associated with TORCH (toxoplasmosis, others, rubella, cytomegalovirus, herpes virus) infections, dermal extramedullary hematopoiesis, infiltrative neoplastic lesions of the skin, and cutaneous vascular anomalies. [12] We present a case of a 9-month-old male infant who was referred to our outpatient department with multiple asymptomatic reddish to bluish raised lesions over the body since 1 month.…”

“…Blueberry muffin syndrome, a rare neonatal skin disorder, is characterized by widespread non blanchable, maculopapular lesions of reddish-blue or magenta color seen due to persistent dermal erythropoiesis. [1] The various causes for blueberry muffin syndrome are mentioned in Table 1. [1345] The exact cause of prolonged dermal erythropoiesis in blueberry muffin syndrome is unknown, but it is hypothesized that during normal embryologic development, extramedullary hematopoiesis occurs in a number of organs, including the dermis and this activity persists until the fifth month of gestation.…”

“…[1345] The exact cause of prolonged dermal erythropoiesis in blueberry muffin syndrome is unknown, but it is hypothesized that during normal embryologic development, extramedullary hematopoiesis occurs in a number of organs, including the dermis and this activity persists until the fifth month of gestation. [1] The presence of blueberry muffin lesions at birth represents postnatal expression of this normal fetal extramedullary hematopoiesis. [1] Although most commonly these lesions present in neonatal life, presentation in infantile period has also been noted.…”

“…[1] The presence of blueberry muffin lesions at birth represents postnatal expression of this normal fetal extramedullary hematopoiesis. [1] Although most commonly these lesions present in neonatal life, presentation in infantile period has also been noted. [6]…”

“…Evaluation of blueberry muffin baby begins with careful review of the pregnancy history and prenatal laboratory studies with a special focus on infectious serologies of mother and baby. [1] Histopathology shows foci of dermal erythropoiesis along with aggregates of nucleated and non-nucleated erythrocyte precursors, but generally no cells of myeloid/megakaryocytic type. [4] A stepwise approach in a suspected case of blueberry muffin baby has been highlighted in Table 2.…”