Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial

Nieman, David C.; Gillitt, Nicholas D.; Chen, Guan-Yuan; Zhang, Qibin; Wang, Sha; Kay, Colin D.; Chandra, Preeti; Kay, Kristine; Lila, Mary Ann

doi:10.3389/fnut.2020.00121

Cited by 27 publications

(95 citation statements)

References 48 publications

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“…As shown in Table 2 , since 2005, 38 articles have reported the effects of flavonoid-enriched extracts on sports performances [ 26 , 28 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ], mainly using cycling and running performances but, also, strength testing, vertical jump, taekwondo, and the climbing test. These 38 articles referred to 37 clinical trials, because the articles by Nieman et al [ 97 ] and Ahmed et al [ 98 ] used the same clinical trial.…”

Section: Resultsmentioning

confidence: 99%

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Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

et al. 2021

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Flavonoids are attracting increasing attention due to their antioxidant, cardioprotective, and immunomodulatory properties. Nevertheless, little is known about their role in exercise performance in association with immune function. This systematic review firstly aimed to shed light on the ergogenic potential of flavonoids. A search strategy was run using SCOPUS database. The returned studies were screened by prespecified eligibility criteria, including intervention lasting at least one week and performance objectively quantified, among others. Fifty-one studies (54 articles) met the inclusion criteria, involving 1288 human subjects, either physically untrained or trained. Secondly, we aimed to associate these studies with the immune system status. Seventeen of the selected studies (18 articles) assessed changes in the immune system. The overall percentage of studies reporting an improved exercise performance following flavonoid supplementation was 37%, the proportion being 25% when considering quercetin, 28% for flavanol-enriched extracts, and 54% for anthocyanins-enriched extracts. From the studies reporting an enhanced performance, only two, using anthocyanin supplements, focused on the immune system and found certain anti-inflammatory effects of these flavonoids. These results suggest that flavonoids, especially anthocyanins, may exert beneficial effects for athletes’ performances, although further studies are encouraged to establish the optimal dosage and to clarify their impact on immune status.

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Section: Resultsmentioning

confidence: 99%

“…All of them were randomized controlled trials and double-blinded. Seven studies [ 73 , 75 , 76 , 78 , 79 , 80 , 83 ] had a crossover design, and the other six [ 77 , 82 , 83 , 84 , 86 , 87 ] had a parallel design.…”

Section: Resultsmentioning

confidence: 99%

Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

et al. 2021

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“…Consistent with this hypothesis, rodent experimental models of muscle injury were recently found to markedly increase intramuscular lipid mediators (47, 48). However, aerobic exercise, which is generally not thought to inflict substantial muscle damage, was also recently shown to result in marked increases in plasma lipid mediator concentrations (90, 91). The remarkable capacity of mechanically overloaded tendon to produce bioactive lipid mediators identified in the current study suggests that tendon may also be an important and underappreciated cellular source of systemic lipid mediator to exercise (92).…”

Section: Discussionmentioning

confidence: 99%

Local Shifts in Inflammatory and Resolving Lipid Mediators in Response to Tendon Overuse

Markworth

Sugg

Sarver

et al. 2021

Preprint

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Tendon inflammation has been implicated in both adaptive connective tissue remodeling and overuse-induced tendinopathy. Lipid mediators control the initiation and resolution of inflammation, but their roles within tendon are largely unknown. Here we profiled local shifts in intratendinous lipid mediators via liquid chromatography-tandem mass spectrometry in response to synergist ablation-induced plantaris tendon overuse. Sixty-four individual lipid mediators were detected in homogenates of habitually loaded plantaris tendons from healthy ambulatory rats. This included many bioactive metabolites of the cyclooxygenase (COX), lipoxygenase (LOX), and epoxygenase (CYP) pathways. Synergist ablation induced a robust inflammatory response at day 3 post-surgery characterized by epitenon infiltration of polymorphonuclear leukocytes (PMNs) and macrophages (MΦ), heightened expression of inflammation-related genes, and increased intratendinous concentrations of the pro-inflammatory eicosanoids thromboxane B2 (TXB2) and prostaglandin E2 (PGE2). By day 7, MΦ became the predominant myeloid cell type in tendon and there were further delayed increases in other COX metabolites including PGD2, PGF2α and PGI2. Specialized pro-resolving mediators (SPMs) including protectin D1 (PD1) and resolvin D6 (RvD6), as well as related pathway markers of D-resolvins (17-HDoHE), E-resolvins (18-HEPE) and lipoxins (15-HETE) were also increased locally in response to tendon overuse, as were many anti-inflammatory fatty acid epoxides of the CYP pathway (e.g. EpETrEs). Nevertheless, intratendinous prostaglandins remained markedly increased even following 28 days of tendon overuse together with a lingering MΦ presence. These data reveal a delayed and prolonged local inflammatory response to tendon overuse characterized by an overwhelming predominance of pro-inflammatory eicosanoids and a relative lack of pro-resolving lipid mediators.

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“…Polyphenols containing flavonoids, phenolic acids, lignans, and stilbenes are the most diverse non-nutrient group of phytochemicals that are produced as secondary metabolites throughout plants and have a broad spectrum of effects on metabolic health [ 77 ]. Polyphenol research of the athletic population has often been conducted using various fruits and vegetables, mainly berries [ 78 ], including blueberries [ 79 , 80 , 81 , 82 ], black currant [ 83 ], Montgomery cherry [ 84 , 85 ], and pomegranate [ 86 ]. Acute polyphenol intake or supplementation of ~300 mg 1–2 h before training or >1000 mg of polyphenol supplementation (equivalent to 450 g blueberries, 120 g blackcurrants or 300 g Montmorency cherries) 3 to more days (1–6 weeks) before and immediately after training is recommended as a countermeasure to improve antioxidant and anti-inflammatory response mechanisms [ 87 ].…”

Section: Popular Diets Applied To Improve Sports Performance In Enmentioning

confidence: 99%

Efficacy of Popular Diets Applied by Endurance Athletes on Sports Performance: Beneficial or Detrimental? A Narrative Review

2021

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Endurance athletes need a regular and well-detailed nutrition program in order to fill their energy stores before training/racing, to provide nutritional support that will allow them to endure the harsh conditions during training/race, and to provide effective recovery after training/racing. Since exercise-related gastrointestinal symptoms can significantly affect performance, they also need to develop strategies to address these issues. All these factors force endurance athletes to constantly seek a better nutritional strategy. Therefore, several new dietary approaches have gained interest among endurance athletes in recent decades. This review provides a current perspective to five popular diet approaches: (a) vegetarian diets, (b) high-fat diets, (c) intermittent fasting diets, (d) gluten-free diet, and (e) low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diets. We reviewed scientific studies published from 1983 to January 2021 investigating the impact of these popular diets on the endurance performance and health aspects of endurance athletes. We also discuss all the beneficial and harmful aspects of these diets, and offer key suggestions for endurance athletes to consider when following these diets.

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Blueberry and/or Banana Consumption Mitigate Arachidonic, Cytochrome P450 Oxylipin Generation During Recovery From 75-Km Cycling: A Randomized Trial

Cited by 27 publications

References 48 publications

Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005

Local Shifts in Inflammatory and Resolving Lipid Mediators in Response to Tendon Overuse

Efficacy of Popular Diets Applied by Endurance Athletes on Sports Performance: Beneficial or Detrimental? A Narrative Review

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