Blue Nevus and Its Distinction from Mongolian Spot and the Nevus of Ota*†‡

Dorsey, Clete S.; Montgomery, Hamilton

doi:10.1038/jid.1954.28

Cited by 205 publications

(75 citation statements)

References 7 publications

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“…17 In contrast, all of the cases in our series consisted of distinctly biphenotypic melanocytic proliferations (melanoma together with a benign blue nevus component). The most common associated blue nevus pattern in our series was both common and cellular blue nevus (nine cases; 38%), followed by cellular blue nevus (seven cases; 29%), and common blue nevus (six cases; 25%).…”

Section: Discussionmentioning

confidence: 57%

“…Overall, there is a slight male preponderance described in the literature (56 lesions in males compared with 51 women)-in contrast to our findings (9 men to 15 women). The most common anatomic site for these lesions is the head and neck region in 52 cases, 4,5,7,11,13,[15][16][17][18][19][20][21]23,24,27,28,31,33,36,39,42,[46][47][48]51,53 followed by the trunk in 28 cases, 4,5,7,[11][12][13]16,18,25,32,34,35,38,43,45,50,52 the lower extremity in 11 cases, 4,7,13,14,26,30,33...…”

Section: Discussionmentioning

confidence: 99%

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Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

et al. 2014

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Melanomas arising in association with blue nevi or mimicking cellular blue nevi comprise a relatively rare and heterogeneous group of melanomas. It remains controversial which prognostic indicators predictive of outcome in conventional cutaneous melanomas are applicable to this type of melanoma. Here, we describe the clinical and histopathologic features of 24 melanomas arising in association with blue nevi and correlate these with clinical outcome. The mean patient age was 49 years (range: 23-85) with a slight female predominance (15 females:9 males). The most common anatomic locations included the head and neck region (50%), the trunk (21%), and the buttock/sacrococcygeum (17%). Histologically, the tumors were typically situated in the mid to deep dermis with variable involvement of the subcutis, but uniformly lacked a prominent intraepithelial component. The mean tumor thickness (defined as either the standard Breslow thickness or, if not available due to the lack of orientation or lack of epidermis, the largest tumor dimension) was 20.9 mm (range: 0.6-130 mm). The mean mitotic figure count was 6.5/mm 2 (range: 1-30/mm 2 ). Perineural invasion was common (38%). Followup was available for 21 cases (median 2.1 years). The median overall survival, recurrence-free survival, time to local recurrence, and time to distant recurrence were 5.2, 0.7, 2.6, and 1.6 years, respectively. Logistic regression analyses demonstrated a significant association between tumor thickness and recurrence-free survival (hazard ratio ¼ 1.02 per mm; P ¼ 0.04) and reduced time to distant metastasis (hazard ratio ¼ 1.03 per mm; P ¼ 0.02) with a similar trend toward reduced time to local recurrence (hazard ratio ¼ 1.02 per mm; P ¼ 0.07). No other parameters (age, anatomic location, mitotic figures, lymphovascular or perineural invasion, or type of associated blue nevus) emerged as significant. In addition, we provide a comprehensive review of 109 cases of melanoma blue nevus type described in the English literature and summarize our findings in this context.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

et al. 2014

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“…Page et al [9] reviewed the non-Orientals with oral involvement of nevus of Ota. They found only 7 cases reported in the literature, 5 in whites [9,10,11,12,13], 2 in blacks [20]. All had, in addition to the oral mucosal pigmentation, an involvement of the ipsilateral facial skin and the eye.…”

Section: Discussionmentioning

confidence: 99%

“…Dorsey and Montgomery [10] reviewed 200 blue nevi, 85% being common blue nevi and 15% cellular blue nevi. 53% were located on or near the dorsa of hands and feet.…”

Section: Discussionmentioning

confidence: 99%

Plaque-Type Blue Nevus of the Oral Cavity

Fistarol

Itin²

2005

Dermatology

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Background: The blue nevus of the oral cavity is a rare lesion with important differential diagnoses. The plaque-type blue nevus is an uncommon variant of the blue nevus. Because of its particular clinical appearance, it can easily be confused with satellite metastases from malignant melanoma. The diagnosis usually requires a biopsy. Objectives: To describe the clinical and histological features of a plaque-type blue nevus of the buccal mucosa in a 20-year-old white woman, to review all intraoral blue nevi and all plaque-type blue nevi reported in the literature so far and to compare the criteria of blue nevi and nevus of Ota. Results: An intraoral blue nevus was described for the first time in 1959. Since then around 70 further cases have been documented. Our case is the first report of a plaque-type blue nevus of the oral cavity. Conclusions: The exceptional widespread intraoral blue nevus described herein can clinically be confused with an intraoral malignant melanoma, and it has a very similar clinical appearance as the intraoral part of nevus of Ota. Apart from the clinical resemblance, there is also some degree of histological overlap of the dermal melanocytoses. Transitional states between blue nevus and nevus of Ota may occur clinically and histologically.

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“…Blue nevi are usually solitary, but sometimes they may be multiple and grouped in an area, a pattern of arrange ment that is more properly designed in the dermatologic lit erature under the term 'agminated' [ 11. Only a few cases of agminated blue nevi have been reported [2][3][4][5][6][7][8], some of them under the names of plaque-type blue nevus [4,8] and eruptive blue nevi [6], We prefer the first designation because we think that it is more descriptive. In this paper we report an additional patient with agminated blue nevi.…”

Section: Introductionmentioning

confidence: 99%

Agminated Blue Nevi: Case Report and Review of the Literature

et al. 1993

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Blue nevi may rarely appear in multiple form and grouped in a circumscribed area, a pattern of arrangement that is more properly designed under the term agminated blue nevi. In this paper a new case with light and ultrastructural studies is described, and the previously reported cases are reviewed. Histologically, there was a characteristic perifollicular arrangement of dermal melanocytes, most of which showed ultrastructurally an extracellular sheath. Agminated blue nevi seem to be benign lesions, but because of their rarity, no definite prognosis can be given.

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Blue Nevus and Its Distinction from Mongolian Spot and the Nevus of Ota*†‡

Cited by 205 publications

References 7 publications

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

Plaque-Type Blue Nevus of the Oral Cavity

Agminated Blue Nevi: Case Report and Review of the Literature

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