Blue light-triggered Fe2+-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy

Yang, Yingchun; Tian, Qingfeng; Wu, Shuqi; Li, Yixiao; Yang, Ke; Yan, Yi; Li, Shang; Li, Aipeng; Zhang, Lianbing

doi:10.1016/j.biomaterials.2021.120739

Cited by 68 publications

(43 citation statements)

References 55 publications

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“…A combination of DOX and Fe 2+ /Fe 3+ should, therefore, efficiently induce CDT. Fe 2+ /Fe 3+ redox pair-based Fenton reaction-mediated biocatalytic tumour therapy has been widely used for tumour-specific iron delivery [ 24 , 25 ]. Fe 2+ also triggers ferroptosis by non-enzymatic lipid peroxidation and lipid auto-oxidation [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

Zhou

et al. 2021

J Nanobiotechnol

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Background Hepatocellular carcinoma is insensitive to many chemotherapeutic agents. Ferroptosis is a form of programmed cell death with a Fenton reaction mechanism. It converts endogenous hydrogen peroxide into highly toxic hydroxyl radicals, which inhibit hepatocellular carcinoma progression. Methods The morphology, elemental composition, and tumour microenvironment responses of various organic/inorganic nanoplatforms were characterised by different analytical methods. Their in vivo and in vitro tumour-targeting efficacy and imaging capability were analysed by magnetic resonance imaging. Confocal microscopy, flow cytometry, and western blotting were used to investigate the therapeutic efficacy and mechanisms of complementary ferroptosis/apoptosis mediated by the nanoplatforms. Results The nanoplatform consisted of a silica shell doped with iron and disulphide bonds and an etched core loaded with doxorubicin that generates hydrogen peroxide in situ and enhances ferroptosis. It relied upon transferrin for targeted drug delivery and could be activated by the tumour microenvironment. Glutathione-responsive biodegradability could operate synergistically with the therapeutic interaction between doxorubicin and iron and induce tumour cell death through complementary ferroptosis and apoptosis. The nanoplatform also has a superparamagnetic framework that could serve to guide and monitor treatment under T2-weighted magnetic resonance imaging. Conclusion This rationally designed nanoplatform is expected to integrate cancer diagnosis, treatment, and monitoring and provide a novel clinical antitumour therapeutic strategy. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

Zhou

et al. 2021

J Nanobiotechnol

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“…Given the increased iron levels in cancer cells, therapeutic strategies targeting unstable iron pools are feasible. Very recently, monodispersed ferrihydrite NPs, synthesized inspired by organisms that naturally synthesize ferrihydrite biominerals, were reported to release enormous amounts of free Fe 2+ and mediate related lipid ROS production after being excited by blue light 52 . The advantage of this approach is that it overcomes the in vivo toxicity in humans caused by the vast majority of Fe 2+ releasing particles.…”

Section: Ideas For the Development Of Nanomaterials To Target Ferroptosismentioning

confidence: 99%

Targeting ferroptosis-based cancer therapy using nanomaterials: strategies and applications

et al. 2021

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As an iron-dependent mode of programmed cell death induced by lipid peroxidation, ferroptosis plays an important role in cancer therapy. The metabolic reprogramming in tumor microenvironment allows the possibility of targeting ferroptosis in cancer treatment. Recent studies reveal that nanomaterials targeting ferroptosis have prospects for the development of new cancer treatments. However, the design ideas of nanomaterials targeting ferroptosis sometimes vary. Therefore, in addition to the need for a systematic summary of these ideas, new ideas and insights are needed to make possible the construction of nanomaterials for effectively targeting this cell death pathway. At the same time, further optimization of nanomaterials design is required to make them appropriate for clinical treatment. In this context, we summarize this cross-cutting research area covering from the known mechanism of ferroptosis to providing feasible ideas for nanomaterials design as well as their clinical application. We aim to provide new insights and enlightenment for the next step in developing new nanomaterials for cancer treatment.

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“…PEG-Fns NPs are highly biocompatible and taken up by the tumor cells. Under blue light illumination, they release Fe 2+ , which increases ROS levels, which in turn inhibit GPX4 activity (e.g., FERR induction) and induce DNA damage (e.g., apoptosis) [65]. Furthermore, the intravenous injection of these NPs in mice bearing 4T1 tumors induces M1 TAM polarization and reduces pulmonary metastasis.…”

Section: Nanoparticles For Radiofrequency Ablation Hyperthermia and Photodynamic Therapymentioning

confidence: 99%

Nanoparticles for Ferroptosis Therapy in Cancer

Zaffaroni

Beretta

2021

Pharmaceutics

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Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy.

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Blue light-triggered Fe2+-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy

Cited by 68 publications

References 55 publications

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis

Targeting ferroptosis-based cancer therapy using nanomaterials: strategies and applications

Nanoparticles for Ferroptosis Therapy in Cancer

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