Blue light-induced low mechanical stability of ruthenium-based coordination bonds: an AFM-based single-molecule force spectroscopy study

Muddassir, Mohd.

doi:10.1039/d0ra07274e

Cited by 3 publications

(1 citation statement)

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“…By changing metal ion or ligands, species dynamics can be tuned. The mechanical strength of many coordination bonds intensities was measured by AFM-based SMFS, which were approximately in the range of the ~10 2 pN scale [ 81 , 82 , 83 ]. By using the ferredoxin which includes a Fe 2 S 4 cluster as model, we have found that the average of mechanical rupture force of Fe-S bond is ~240 pN ( Figure 3 D) [ 39 ].…”

Section: Dynamic Covalent Chemistrymentioning

confidence: 99%

Dynamic Covalent Hydrogels: Strong yet Dynamic

Han

Cao

Lei

2022

Gels

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Hydrogels are crosslinked polymer networks with time-dependent mechanical response. The overall mechanical properties are correlated with the dynamics of the crosslinks. Generally, hydrogels crosslinked by permanent chemical crosslinks are strong but static, while hydrogels crosslinked by physical interactions are weak but dynamic. It is highly desirable to create synthetic hydrogels that possess strong mechanical stability yet remain dynamic for various applications, such as drug delivery cargos, tissue engineering scaffolds, and shape-memory materials. Recently, with the introduction of dynamic covalent chemistry, the seemingly conflicting mechanical properties, i.e., stability and dynamics, have been successfully combined in the same hydrogels. Dynamic covalent bonds are mechanically stable yet still capable of exchanging, dissociating, or switching in response to external stimuli, empowering the hydrogels with self-healing properties, injectability and suitability for postprocessing and additive manufacturing. Here in this review, we first summarize the common dynamic covalent bonds used in hydrogel networks based on various chemical reaction mechanisms and the mechanical strength of these bonds at the single molecule level. Next, we discuss how dynamic covalent chemistry makes hydrogel materials more dynamic from the materials perspective. Furthermore, we highlight the challenges and future perspectives of dynamic covalent hydrogels.

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Section: Dynamic Covalent Chemistrymentioning

confidence: 99%

Dynamic Covalent Hydrogels: Strong yet Dynamic

Han

Cao

Lei

2022

Gels

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Transforming de novo protein α₃D into a mechanically stable protein by zinc binding

et al. 2021

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Exploration of Metal-Ligand Coordination Bonds in Proteins by Single-molecule Force Spectroscopy

et al. 2021

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Blue light-induced low mechanical stability of ruthenium-based coordination bonds: an AFM-based single-molecule force spectroscopy study

Abstract: A HA–RuII complex was conjugated to a hyaluronan polymer through amide bonds. In AFM experiments using the “multi-fishhook” approach, the cantilever tip made contact with the polymeric molecule, resulting in stretching, indicated by sawtooth-like force-extension curves.

Cited by 3 publications

References 60 publications

Dynamic Covalent Hydrogels: Strong yet Dynamic

Dynamic Covalent Hydrogels: Strong yet Dynamic

Transforming de novo protein α₃D into a mechanically stable protein by zinc binding

Exploration of Metal-Ligand Coordination Bonds in Proteins by Single-molecule Force Spectroscopy

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Blue light-induced low mechanical stability of ruthenium-based coordination bonds: an AFM-based single-molecule force spectroscopy study

Abstract: A HA–RuII complex was conjugated to a hyaluronan polymer through amide bonds. In AFM experiments using the “multi-fishhook” approach, the cantilever tip made contact with the polymeric molecule, resulting in stretching, indicated by sawtooth-like force-extension curves.

Cited by 3 publications

References 60 publications

Dynamic Covalent Hydrogels: Strong yet Dynamic

Dynamic Covalent Hydrogels: Strong yet Dynamic

Transforming de novo protein α3D into a mechanically stable protein by zinc binding

Exploration of Metal-Ligand Coordination Bonds in Proteins by Single-molecule Force Spectroscopy

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Product

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Transforming de novo protein α₃D into a mechanically stable protein by zinc binding