Blue light-filtering intraocular lenses and post-operative mood: a pilot clinical study

Abstract

The purpose of the study was to determine if implantation of blue-filtering intraocular lenses (IOLs) affects post-operative mood, inducing more depression, compared to patients undergoing implantation with conventional IOLs. The study was conducted at the Angers University Hospital, France. This was a prospective with a lowercase pilot study, including consecutive patients planned to undergo cataract surgery in both eyes within 1 week. The same type of IOL was used in both eyes of each patient. The choice of IOL was not randomized but driven by the habits and experience of each participating surgeon. Cognitively healthy patients (an MMSE score higher than 25) were assessed before and after surgery, using the 30-item geriatric depression scale (GDS) to seek symptoms of depression. Univariate and multiple logistic regressions were used to examine the association between the type of IOL and the 30-item GDS score improvement during the 3 months after lens implantation, while adjusting for participants' characteristics (age, visual acuity). Blue-filtering IOLs were used in 16 patients (mean ± standard deviation, 75.6 ± 7.5 years; 75 % female), and untinted IOLs in 18 patients (77.3 ± 6.9 years; 77.8 %female). Pre-operatively visual acuity and GDS scores were comparable in the two groups. The post-operative GDS score was improved by 1.91 ± 3.10 points in the whole sample (P = 0.002), as well as in each subgroup of patients. Three months after surgery, the mean change in GDS score did not differ between groups (P = 0.365), nor did the mean visual acuity (P = 0.198).

Pupillary responses to short-wavelength light are preserved in aging

“…However, the PIPR did not differ between patients with blue-blocking IOLs versus neutral IOLs. Other studies have found that short-term improvements in sleep quality and depression scores following lens replacement are equivalent for IOLs that filter blue light versus those that only block UV light626364. These findings suggest that reduced transmission of blue light with IOLs might have limited clinical impact on non-visual light responses, similar to our findings for the pupillary light reflex in nonpathalogical aging.…”

Impact of cataract surgery on depression and cognitive function: Systematic review and meta‐analysis

“…Finally, 16 articles that met the inclusion criteria were included in the meta‐analysis (Table S1). 22‐37 …”

“…The studies were published between 1996 and 2018 and included a total number of 1308 patients who underwent cataract surgery. Five of them were conducted in the United States, 23,24,30,31,34 two in China, 29,33 two in Japan, 25,35 two in Vietnam, 22,36 one in the United Kingdom, 26 one in Iran, 27 one in France, 28 one in Greece 32 and one in Australia 37 . The duration of the follow up ranged from 1 to 12 months.…”

Sleep and mood changes in advanced age after blue-blocking (yellow) intra ocular lens (IOLs) implantation during cataract surgical treatment: a randomized controlled trial

“…To our knowledge, only three non-randomized studies have compared the effects of clear and yellow IOLs on circadian rhythms with a focus on sleep. One study involved 34 patients (Leruez et al, 2015), another study included 49 patients (Landers, Tamblyn, & Perriam, 2009), and another larger study included 961 patients (Alexander et al, 2014). None of these studies reported differences regarding quality of life or quality of sleep between patients in the clear or yellow IOLs groups.…”