Blue-Blocking IOLs: A Complete Review of the Literature

Henderson, Bonnie An; Grimes, Kelly J.

doi:10.1016/j.survophthal.2009.07.007

Cited by 58 publications

(60 citation statements)

References 52 publications

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“…4 The clear, ultraviolet (UV)-blocking and the yellow-colored IOLs currently available show similar properties in terms of visual function with the exception of vision in mesopic or scotopic light conditions. [5][6][7][8][9] Glare reduction is an additional advantage of yellow-colored IOL, although concerns have been raised that the blue lightblocking effects of such a lens might disturb normal circadian rhythms 10,11 because intrinsically photosensitive retinal ganglion cells mediate melatonin secretion by photoreception of blue light. [12][13][14] On the contrary, clear IOLs do not block visible light transmission and thus offer no protection to the retina from the potentially damaging effects of bright light, [15][16][17][18][19][20] although the protective effect of a blue lightblocking IOL is elusive.…”

Section: Introductionmentioning

confidence: 99%

Rejuvenation Effects of Cataract Surgery with Ultraviolet Blocking Intra-Ocular Lens on Circadian Rhythm and Gait Speed

Ayaki

Negishi

Tsubota

2014

Rejuvenation Research

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Background: Previously, we reported improvements in sleep quality and gait speed after implantation of a yellow-colored, blue light-blocking intra-ocular lens (IOL). This study evaluated systemic health parameters for 7 months after cataract surgery with implantation of a clear, ultraviolet (UV)-blocking IOL. Methods: A total of consecutive 71 patients (average age 74.1 years) underwent cataract surgery with the implantation of a clear, UV-blocking IOL. Participants were evaluated using the Pittsburgh Sleep Quality Index (PSQI) and the National Eye Institute Visual Function Questionnaire (VFQ-25) before and at 2 and 7 months after surgery. Four-meter gait speed was also determined. The metabolic parameters of serum glycated hemoglobin (HbA1c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were tested. Results: The pre-operative and post-operative (2 and 7 months after surgery) results were 66.4 -16.5, 79.5 -12.6, and 81.0 -13.0 for VFQ-25 score, 5.7 -3.5, 5.1 -3.1, and 4.8 -2.9 for PSQI, and 0.90 -0.22, 0.91 -0.22, and 0.92 -0.22 meters/sec for gait speed. Significant improvements following surgery were noted in the VFQ-25 score for all cases and in the PSQI for poor sleepers (preoperative PSQI > 5.5) (P < 0.05, paired t-test). The gait speed and metabolic parameters showed no significant changes. Conclusions: Cataract surgery with implantation of an UV-blocking clear IOL has the potential for improving circadian rhythm and systemic health parameters.

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Section: Introductionmentioning

confidence: 99%

Rejuvenation Effects of Cataract Surgery with Ultraviolet Blocking Intra-Ocular Lens on Circadian Rhythm and Gait Speed

Ayaki

Negishi

Tsubota

2014

Rejuvenation Research

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“…Improvement in contrast sensitivity, reduced glare under photopic and mesopic conditions and reduction in disturbance of blue color vision are also expected. These changes could confound the interpretation of the glaucomatous visual field (15)(16)(17)(18)(19)(20) . In our study, no statistically difference was found in contrast sensitivity comparing yellow tinted and clear IOLs.…”

Section: Discussionmentioning

confidence: 99%

Effect of aspherical and yellow tinted intraocular lens on blue-on-yellow perimetry

Espíndola

Santhiago

Kara-Júnior

2012

Arq. Bras. Oftalmol.

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Purpose:To investigate the possible effect of aspherical or yellow tinted intraocular lens (IOL) on contrast sensitivity and blue-on-yellow perimetry. Methods: This prospective randomized bilateral double-masked clinical study included 52 patients with visually significant bilateral cataracts divided in two groups; 25 patients (50 eyes) received aspherical intraocular lens in one eye and spherical intraocular lens in the fellow eye; and 27 patients (54 eyes) received ultraviolet and blue light filter (yellow tinted) IOL implantation in one eye and acrylic ultraviolet filter IOL in the fellow eye. The primary outcome measures were contrast sensitivity and blue-on-yellow perimetry values (mean deviation [MD] and pattern standard deviation [PSD]) investigated two years after surgery. The results were compared intra-individually. Results: There was a statistically significant between-group (aspherical and spherical intraocular lens) difference in contrast sensitivity under photopic conditions at 12 cycles per degree and under mesopic conditions at all spatial frequencies. There were no between-group significant differences (yellow tinted and clear intraocular lens) under photopic or mesopic conditions. There was no statistically significant difference between all intraocular lens in MD or PSD. Conclusion: Contrast sensitivity was better under mesopic conditions with aspherical intraocular lens. Blue-on-yellow perimetry did not appear to be affected by aspherical or yellow tinted intraocular lens. Further studies with a larger sample should be carried out to confirm or not that hypotheses. Keywords

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“…[1][2][3] However, there is good evidence from animal and cell culture studies that a BFIOL can exert a protective effect. [25][26][27][28][29][30][31] Despite the potential for damage demonstrated by the results of these studies, it has been said that these findings may not be directly applicable to the development or progression of AMD in humans.…”

Section: Age-related Macular Degeneration and Iol Typementioning

confidence: 99%

“…[1][2][3][4][5] BFIOLs are also referred to as yellow-or orange-tinted intraocular lenses (IOLs). Historically, the impetus to develop BFIOLs was to reduce chromatic aberration, and cyanopsia, where the recipient of the IOL notices a blue tinge to their vision post surgery, 3 and to provide protection against short-wavelength light because of the evidence that shortwavelength light is toxic to the retina and retinal pigment epithelium.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 There have been excellent comprehensive articles reviewing this subject in detail and a more recent metaanalysis by Zhu in 2012. [1][2][3][4][5] Since then more information has become available regarding the impact of the BFIOL on the sleep-wake cycle, 17,18 blood pressure, 19 mood, 20 and cognitive function 18 as well as early small studies looking at age-related macular degeneration (AMD) development. 21,22 Photoprotection and photoreception Transmittance and absorption properties of BFIOLs and UVFIOLs have been compared with each other, as well as to the natural crystalline lens.…”

Section: Introductionmentioning

confidence: 99%

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