Bloodstream yeast infections in a university hospital in Northeast Turkey: a 4-year survey

Abstract

This study presents data on species distribution and antifungal susceptibility profiles of Candida bloodstream isolates obtained from a Turkish Tertiary Care Hospital during a 4-year period. All hospitalized patients who had ≥ 1 blood culture positive for yeast during their hospital stay from January 2005 through 2009 were included in this study. All isolates were identified to species level using CHROMagar and ID 32 C. Fluconazole and voriconazole antifungal susceptibility testing was performed using the disk diffusion method according to CLSI M44-A. In vitro activity of amphotericin B was determined by the Etest. Of all 166 yeast isolates, C. albicans was the dominant species (34.3%), followed by Candida parapsilosis (28.9%) and C. tropicalis (8.4%). All of the 48 C. parapsilosis strains were identified as C. parapsilosis sensu stricto. Resistance to fluconazole was more common among C. krusei isolates. Voriconazole resistance was absent. One C. lusitaniae strain showed a high amphotericin MIC (4 μg/ml). Our survey indicated an increase of some non-C. albicans Candida species in our hospital while antifungal resistance was uncommon.

Epidemiology of candidaemia in a tertiary care university hospital: 10‐year experience with 381 candidaemia episodes between 2001 and 2010

“…[16][17][18][55][56][57] The diverse distribution patterns of Candida species are also observed across similar studies conducted in Turkey. [58][59][60][61][62][63][64] In contrast to the predominance of C. albicans in our study, as a group, the NAC species exceeded C. albicans in most of these studies. [58][59][60]62,64 While as a single aetiological agent, C. albicans is reported as the leading cause of candidaemia, the second most common species varies between C. parapsilosis and C. tropicalis, with a greater tendency towards C. parapsilosis at higher rates than in our study.…”

“…[58][59][60][61][62][63][64] In contrast to the predominance of C. albicans in our study, as a group, the NAC species exceeded C. albicans in most of these studies. [58][59][60]62,64 While as a single aetiological agent, C. albicans is reported as the leading cause of candidaemia, the second most common species varies between C. parapsilosis and C. tropicalis, with a greater tendency towards C. parapsilosis at higher rates than in our study. [58][59][60][61][62][63] Nonetheless, our study shares the common features of relatively low rates of C. glabrata, and I. orientalis reported in Turkish series.…”

“…[58][59][60]62,64 While as a single aetiological agent, C. albicans is reported as the leading cause of candidaemia, the second most common species varies between C. parapsilosis and C. tropicalis, with a greater tendency towards C. parapsilosis at higher rates than in our study. [58][59][60][61][62][63] Nonetheless, our study shares the common features of relatively low rates of C. glabrata, and I. orientalis reported in Turkish series. [59][60][61][62][63] The current study, including 381 candidaemia episodes during a 10-year period, gives us the opportunity to compare the epidemiology of candidaemia throughout the whole decade from 2001 to 2010.…”

Klinik Candida lusitaniae Kökenlerinin Amfoterisin B'ye İn Vitro Duyarlılığı: Çok Merkezli Çalışma

“…Az sayıdaki çalışmada ise birer köken AmB dirençli bulunmuştur (20,21) . In vitro çalışmaların büyük kısmından elde edilen sonuçlara göre C. lusitaniae kökenleri AmB'ye bütünüyle duyarlıdır.…”

An outbreak of Candida parapsilosis fungemia among preterm infants

“…Unfortunately, the increased survival rate of these high-risk infants has led to a concomitant rise in the incidence of Candida infections; over the past decade, the incidence of Candida parapsilosis has dramatically increased. In fact, reports indicate that C. parapsilosis is often the second most common Candida species isolated from blood cultures (Kuzucu et al, 2008;Hinrichsen et al, 2008;Pfaller et al, 2010;Aydin et al, 2011).…”