Bloodstream infections due to Peptoniphilus spp.: report of 15 cases

Brown, Kristen; Church, DL; Lynch, Tarah; Gregson, Daniel B.

doi:10.1111/1469-0691.12657

Cited by 50 publications

(44 citation statements)

References 21 publications

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“…Interestingly, half of the GPACs in our study belong to the Peptoniphilus spp., which were described only this year as a rare, but important cause of blood stream infections in certain clinical settings . In our study, Peptoniphilus bacteremia was found in patients with abscesses of the urethra and skin, urinary retention and pyelonephritis, osteomyelitis and gangrene.…”

Section: Discussionsupporting

confidence: 45%

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Anaerobic blood culture isolates in a Norwegian university hospital: identification by MALDI‐TOF MS vs 16S rRNA sequencing and antimicrobial susceptibility profiles

Handal

Jørgensen

Tunsjø

et al. 2015

APMIS

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We investigated 197 anaerobic isolates recovered from blood cultures in the period 2009-2013. The isolates included were Bacteroides spp., Clostridium spp., Prevotella spp., Fusobacterium spp. and Gram-positive anaerobic cocci (GPAC). Identification results by MALDI-TOF MS were compared to those obtained by 16S rRNA sequencing, and the MICs of benzylpenicillin, clindamycin, piperacillin-tazobactam, meropenem and metronidazole were determined by Etests. The MALDI-TOF MS correctly identified 94.9% of the anaerobes to the genus level, and 86.8% to the species level, with errors mainly among the non-fragilis Bacteroides spp. and GPAC. About 73.3% of the isolates were non-susceptible to penicillin, mainly due to high resistance rates in the Bacteroides spp. (99.2%) and Prevotella spp. (69.2%). About 18.5% of the isolates were clindamycin resistant. Piperacillin-tazobactam had an excellent activity against all anaerobes except the non-fragilis Bacteroides spp., of which 43.8% were non-susceptible. The clinical significance of such a high resistance rate is unclear. Meropenem and metronidazole were the most active antibiotics, with 96.9% and 97.9% of the isolates being susceptible.

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Section: Discussionsupporting

confidence: 45%

“…Their 16S rRNA sequences were >99% identical to Peptoniphilus species published by Brown et al. , at the time just designated Peptoniphilus spp. As a consequence, MALDI‐TOF MS identified eight of the nine Peptoniphilus spp.…”

Section: Discussionmentioning

confidence: 60%

Anaerobic blood culture isolates in a Norwegian university hospital: identification by MALDI‐TOF MS vs 16S rRNA sequencing and antimicrobial susceptibility profiles

Handal

Jørgensen

Tunsjø

et al. 2015

APMIS

View full text Add to dashboard Cite

show abstract

“…4). These genera contain opportunistic pathogens47484950 and were not detected in the six healthy controls. It will be important to determine whether the CDV infection-induced increase in the frequency of disease-associated genera could serve as an early predictor and pose health risks to hosts.…”

Section: Discussionmentioning

confidence: 95%

Impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota

Zhao

Luo

et al. 2017

Sci Rep

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The recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and the decline of some endangered species populations. Between December 2014 and March 2015, five captive giant pandas died due to canine distemper virus (CDV) infection in China. CDV has taken a heavy toll on tigers and lions in recent years. Here, we describe the first gut microbiome diversity study of CDV-infected pandas. By investigating the influence of CDV infection on gut bacterial communities in infected and uninfected individuals and throughout the course of infection, we found that CDV infection distorted the gut microbiota composition by reducing the prevalence of the dominant genera, Escherichia and Clostridium, and increasing microbial diversity. Our results highlight that increases in intestinal inflammation and changes in the relative abundances of pathogen-containing gut communities occur when individuals become infected with CDV. These results may provide new insights into therapeutics that target the microbiota to attenuate the progression of CDV disease and to reduce the risk of gut-linked disease in individuals with CDV. In addition, our findings underscore the need for better information concerning the dynamics of infection and the damage caused by pathogens in panda populations.

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“…There are studies demonstrating the healthy male and female urine specimens have different bacterial compositions (Fouts et al, 2012;Lewis et al, 2013). The role of Peptoniphilus in human infections remains highly elusive since it could not be routinely isolated in most laboratories due to the limited culture-based techniques (Brown et al, 2014). Peptoniphilus seems to be part of urethral microbiome being reported from the urine specimens with the bacterial growth of no clinical significance (< 10 4 CFU/mL) by 16S rRNA sequencing (Sabat et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Identification of bacterial vaginosis-associated bacteria in male urethra: Co-occurrence of Atopobium vaginae and Gardnerella vaginalis

Uğur¹,

Tuncer²,

Fındık³

2019

MJM

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Aims: Bacterial vaginosis (BV) is characterized by a transition in vaginal microflora from lactobacilli to anaerobic bacteria. Gardnerella vaginalis and Atopobium vaginae are considered the most responsible pathogens for the etiology of BV. Colonization of male urethra with BV-associated bacteria has been rarely investigated. The aim of this study was to investigate the differences in the presence of BV-associated bacteria in the healthy male urethra in regard to sexual exposure. Methodology and results: The first-catch urine specimens, representative of urethral swabs, from 114 healthy male volunteers, were included in this study.

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Bloodstream infections due to Peptoniphilus spp.: report of 15 cases

Cited by 50 publications

References 21 publications

Anaerobic blood culture isolates in a Norwegian university hospital: identification by MALDI‐TOF MS vs 16S rRNA sequencing and antimicrobial susceptibility profiles

Anaerobic blood culture isolates in a Norwegian university hospital: identification by MALDI‐TOF MS vs 16S rRNA sequencing and antimicrobial susceptibility profiles

Impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota

Identification of bacterial vaginosis-associated bacteria in male urethra: Co-occurrence of Atopobium vaginae and Gardnerella vaginalis

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